This Week in Virology with Vincent Racaniello

TWiV 233: We're surrounded

twiv@twiv.tv (Vincent Racaniello) — Sat, 18 May 2013 13:28:00 +0000

Hosts: Vincent Racaniello, Rich Condit, Alan Dove, and Kathy Spindler

Vincent, Rich, Alan and Kathy review aerosol transmission studies of influenza H1N1 x H5N1 reassortants, H7N9 infections in China, and the MERS coronavirus.

Weekly Science Picks

Alan - Space Oddity (YouTube)
Rich - Walk through giant colon
Vincent - Transport proteins
Kathy - Vomiting Larry (YouTube)

Listener Pick of the Week

Tom - US patent system is broken (DailyTech)

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

TWiV 232: Gophers go viral

twiv@twiv.tv (Vincent Racaniello) — Sun, 12 May 2013 18:21:16 +0000

Hosts: Vincent Racaniello, Roberto Cattaneo, Reuben Harris, Lou Mansky, and Leslie Schiff

Vincent meets up with Roberto, Reuben, Lou, and Leslie at the University of Minnesota to talk about their work on HIV-1, APOBEC proteins, measles virus, and teaching virology to undergraduates.

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

TWiV 231: Hepaciviruses and pegiviruses in bats and rodents

twiv@twiv.tv (Vincent Racaniello) — Sun, 05 May 2013 16:16:07 +0000

Hosts: Vincent Racaniello, Amit Kapoor, Lan Quan, and Ian Lipkin

Vincent meets up with Amit, Lan, and Ian to discuss their discovery of hepaciviruses and pegiviruses in bats and rodents.

Links for this episode:

Canine hepacivirus (TWiV 137)
Rodent homologs of hepaciviruses and pegiviruses (mBio)
Bats are a reservoir of hepaciviruses and pegiviruses (PNAS)

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

TWiV 230: Gene goes to Washington, flu chickens out

twiv@twiv.tv (Vincent Racaniello) — Sun, 28 Apr 2013 14:58:40 +0000

Hosts: Vincent Racaniello, Rich Condit, Alan Dove, and Kathy Spindler

Vincent, Rich, Alan and Kathy review H7N9 infections in China, the debate over patenting genes, and receptor-binding by ferret-transmissible avian H5 influenza virus.

Links for this episode:

Francois Jacob dies (The Loom)
WHO updates on H7N9
H7N9 is unusually dangerous (ScienceInsider)
H7N9 case imported into Taiwan
No H7N9 in poultry farms (Xinhua)
Supreme Court considers gene patents (TheScientist, Nature)
Patent my jeans, not my genes (Michael Wosnick)
Receptor binding by ferret transmissible H5 virus (Nature)
Microscale thermophoresis and bio-layer interferometry (Wikipedia)
Letters read on TWiV 230

Weekly Science Picks

Alan - World Science Festival
Rich - 3 years of the sun in 3 minutes
Vincent - The Origin of AIDS by Jacques Pepin
Kathy - Wringing out a wet washcloth in space (YouTube)

Listener Pick of the Week

Mark - Will it blend? (iPhone app)
Marianne - Enjoy your Cells

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

TWiV 229: Partly cloudy with a high of H7N9

twiv@twiv.tv (Vincent Racaniello) — Sun, 21 Apr 2013 13:46:37 +0000

Hosts: Vincent Racaniello, Rich Condit, Dickson Despommier, and Alan Dove

Vincent, Rich, Dickson, and Alan review the current status of human infections with avian influenza H7N9 virus.

Links for this episode:

Hilary Koprowski, 96 (NY Times)
Koprowski, Kessin, Racaniello photo
Listen to the Music by Roger Vaughan
Influenza ocular infections (one, two)
H7N9 global concerns (NEJM)
Human infection with H7N9 (NEJM)
WHO Global Alert and Response, H7N9
Avian influenza A(H7N9) virus (WHO)
Novel H7N9 reassortant, implications for Europe (Eurosurveill)
Genetic analysis of H7N9 (Eurosurveill)
H7N9 compared with H7N7 outbreaks (Eurosurveill)
Image credit: Eurosurveillance
Letters read on TWiV 229

Weekly Science Picks

Alan - Nature PastCast
Rich - How dengue does it
Vincent - Squeaky Squeegee Art by Deb Sklut
Dickson - Agritecture

Listener Pick of the Week

Mike - Chemistry in its element: Elements and Compounds

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

TWiV 228: Cal Bears go viral

twiv@twiv.tv (Vincent Racaniello) — Sun, 14 Apr 2013 23:24:00 +0000

Hosts: Vincent Racaniello, Britt Glausinger, and Eva Harris

Vincent visits the University of California at Berkeley and speaks with Britt Glaunsinger and Eva Harris about their work on Kaposi's sarcoma associated herpesvirus and dengue virus.

Thanks to the Microbiology Graduate Students for hosting me at their annual symposium, and especially to Emma, Lisa, and Zoe for their wonderful hospitality during my stay.

Links for this episode:

RNA element in IL-6 confers SOX resistance (J Virol)
Dual uORFs regulate herpesviral translation (PLoS Path)
Common viral strategy for RNA degradation (J Virol)
KSHV SOX and Xrn1 together degrade host mRNAs (PLoS Path)
Dengue treatment with Fc null antibodies (PLoS Path)
Early clinical features of dengue in Nicaraguan children (PLoS Negl Trop Dis)
Intrahuman dengue virus diversity (J Virol)
Dynamics of dengue disease severity (Sci Transl Med)

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

TWiV 227: Lacks security and bad poultry

twiv@twiv.tv (Vincent Racaniello) — Sun, 07 Apr 2013 15:15:50 +0000

Hosts: Vincent Racaniello, Rich Condit, Dickson Despommier, Alan Dove, and Kathy Spindler

The complete TWiV team reviews the controversial publication of the HeLa cell genome, a missing vial of Guanarito virus in a BSL-4 facility, and human infections with avian influenza H7N9 virus.

Weekly Science Picks

Kathy - NIAID YouTube videos
Alan - Lego insects
Rich - How to see the world in a grain of sand
Vincent - Vaccines, viruses, and the anti-vax movement
Dickson - Edinburgh Science Festival

Listener Pick of the Week

Stephen - Nature iOS app
Mehul - Voices for vaccines

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

TWiV 226: Taking the viral A train with Terry Dermody

twiv@twiv.tv (Vincent Racaniello) — Sat, 30 Mar 2013 21:07:00 +0000

Hosts: Vincent Racaniello, Dickson Despommier, and Terry Dermody

Vincent and Dickson speak with Terry Dermody about his career in medicine and virology.

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

TWiV 225: Transcripts from the inbox

twiv@twiv.tv (Vincent Racaniello) — Sat, 23 Mar 2013 14:13:00 +0000

Hosts: Vincent Racaniello, Alan Dove, and Kathy Spindler

Vincent, Rich, and Kathy read listener comments and questions on viral oncotherapy, science communication, a functional HIV cure in an infant, and much more.

Links for this episode:

Plant viruses alter insect behavior (Sci Rep)
Circovirus in Shanghai
Letters read on TWiV 225

Weekly Science Picks

Kathy - Case stories about CoV-EMC (one, two)
Rich - The Self-Illusion by Bruce Hood
Vincent - Moving Targets

Listener Pick of the Week

Liam - eLIFE and Rubriq
Steve - Plant virus ecology (mp3)
Neil - World Immunization Week

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

TWiV 224: A wide receiver and a natural defense

twiv@twiv.tv (Vincent Racaniello) — Sun, 17 Mar 2013 13:51:28 +0000

Hosts: Vincent Racaniello, Alan Dove, and Kathy Spindler

Vincent, Alan, Kathy, and Dickson discuss identification of a cell receptor for the coronavirus-EMC, and the role of interferon-epsilon in protecting the female reproductive tract.

Links for this episode:

Dipeptidyl peptidase 4 is CoV-EMC receptor (Nature)
Receptor for new coronavirus (Nature)
Broad reception for coronavirus (Nature)
SARS 10th anniversary (Science)
Interferon-epsilon protects female reproductive tract (Science)
Families fighting flu (YouTube)
Monitoring infections with online data (TWiM 41)
Natalie Portman was a scientist (NY Times)
Letters read on TWiV 223

Weekly Science Picks

Kathy - 2013 Intel Science Talent Search awards
Alan - Krebs Cycle Rap (CDC)
Vincent - Jetpens (favorite one and two)
D ickson - Rabies death in organ recipients (CDC)

Listener Pick of the Week

Justin - The DNA Store
Jim - Massive Open Online Classrooms
Chris - Feedly

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

TWiV 223: EEEV and the serpent

twiv@twiv.tv (Vincent Racaniello) — Sun, 10 Mar 2013 18:10:30 +0000

Hosts: Vincent Racaniello, Alan Dove, and Kathy Spindler

Vincent, Alan, and Kathy discuss new influenza virus NA inhibitors, detection of EEEV antibody and RNA in snakes, and replication of the coronavirus EMC in human airway epithelial cells.

Weekly Science Picks

Kathy - Finkbeiner test and Women in Science
Alan - New flu vaccine efficacy study (CDC)
Vincent - Threading the NEIDL video

Listener Pick of the Week

Steve - Prof. Joan Steitz on viral RNA
Ed - Archiving history of molecular biology: Press release, video, CSHL archives and videos

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

TWiV 222: Jumpin' Jack Flash, it's a GAS GAS GAS

twiv@twiv.tv (Vincent Racaniello) — Sun, 03 Mar 2013 16:20:01 +0000

Hosts: Vincent Racaniello, Rich Condit, Dickson Despommier, Alan Dove, and Kathy Spindler

The complete TWiV team discusses the amazing finding that cyclic GMP-AMP synthase is a cytosolic innate immune DNA sensor.

Links for this episode:

Zhijian J. Chen (Wikipedia)
Sensing the dark side of DNA (Science)
cGAMP is an endogenous second messenger (Science)
cGAMP synthase is a DNA sensor (Science)
Pore-forming toxin (Wikipedia)
Letters read on TWiV 222

Weekly Science Picks

Kathy - Graphene batteries
Alan - How do we get cures? (YouTube)
Rich - Explosive breach of Condit Dam (Vimeo)
Vincent - 10 things you can do to support open access (Tree of Life)

Listener Pick of the Week

Mark - The real story of Stuxnet
John - D-connector virus

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

TWiV 221: Bunya there, done that

twiv@twiv.tv (Vincent Racaniello) — Sun, 24 Feb 2013 16:26:30 +0000

Hosts: Vincent Racaniello, Dickson Despommier, and Kathy Spindler

Vincent, Dickson, and Kathy review two emerging bunyaviruses, SFTSV and SBV.

Weekly Science Picks

Kathy - Winners, 2012 Science & Engineering Visualization Challenge
Vincent - The Operator and Dr. Oz's Problem

Listener Pick of the Week

Shane - OpenPCR
John - Python

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

TWiV 220: Flu watches the clock while T7 gets a CAT scan

twiv@twiv.tv (Vincent Racaniello) — Sun, 17 Feb 2013 16:11:19 +0000

Hosts: Vincent Racaniello, Rich Condit, Alan Dove, and Kathy Spindler

Vincent, Rich, Alan, and Kathy discuss regulation of influenza virus replication by splicing, and the bacteriophage T7 random walk.

Weekly Science Picks

Kathy - Journal of Virology Image Gallery
Rich - Phage T7 Genetics and Physiology and slab gels
Alan - PeerJ (press release)
Vincent - Virologia en Español

Listener Pick of the Week

Dave - Thingiverse pathogens and proteins

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

TWiV 219: Fauci pharmacy

twiv@twiv.tv (Vincent Racaniello) — Sun, 10 Feb 2013 19:59:53 +0000

Hosts: Vincent Racaniello, Rich Condit, and Anthony S. Fauci

Vincent and Rich meet up with Anthony S. Fauci, MD, Director of the National Institute of Allergy and Infectious Diseases.

Links for this episode:

Fauci history (J Clin Inves)
Fauci Pharmacy
Anthony Fauci (Wikipedia)
Anthony Fauci: Unfinished business (Lens)

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

TWiV 218: Monkeys turning valves and pushing buttons

twiv@twiv.tv (Vincent Racaniello) — Sun, 03 Feb 2013 21:54:52 +0000

Hosts: Vincent Racaniello, Alan Dove, and Welkin Johnson

Vincent, Alan, and Welkin discuss how endogenous retroviruses in mice are held in check by the immune response.

Links for this episode:

Kuan-Teh Jeang, 54
Resurrection of ERVs (Nature)
Toll-like receptors control ERVs (Immunity)
Retroviral danger from within (Immunity)
Ancient viruses wreak havoc (The Scientist)
Letters read on TWiV 218

Weekly Science Picks

Welkin - Viruses: Essential Agents of Life (review at STC)
Alan - Infinity Imagined
Vincent - Spaceship built for son

Listener Pick of the Week

Amanda - Written? Kitten!
Kevin - Protein synthesis: An epic (YouTube)
Daria - The Baltimore Scheme

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

TWiV 217: I just flu in and my arms are shot

twiv@twiv.tv (Vincent Racaniello) — Sat, 26 Jan 2013 17:14:00 +0000

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Dickson Despommier

Vincent, Alan, Rich, and Dickson review influenza vaccines.

Links for this episode:

FDA licensed flu vaccines
Seasonal influenza vaccine distributed
How flu vaccine strains are selected (one, two)
WHO report on flu vaccine strain selection (pdf)
Derek Smith on antigenic mapping
Salk's 1945 influenza vaccine
TIV preparation: Fluzone, Agriflu, Fluvirin, Fluarix, Flulaval, Afluria (pdfs)
LAIV preparation (pdf)
Efficacy of flu vaccine 2012-13 (MMWR, virology blog)
Meta-analysis of flu vaccine efficacy (Lancet)
Two new flu vaccines FDA approved
Flublok
Flublok clinical trial
Pandemrix and narcolepsy (Yahoo, PLoS One, PLoS One)
CIDRAP analysis of flu vaccines
Letters read on TWiV 217

Weekly Science Picks

Rich - Repoopulate (original article), Robogut (new clinical trial)
Alan - WTF, Evolution?
Dickson - The Beauty and Benefits of Science
Vincent - Supercomputing modeling of poliovirus

Listener Pick of the Week

Bjorn, Marshall, Meaghan - Glass sculptures of Luke Jerram

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

TWiV 216: Processing VIRALGUUAACACCAGRNA

twiv@twiv.tv (Vincent Racaniello) — Sun, 20 Jan 2013 17:07:00 +0000

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler

Vincent, Alan, Rich, and Kathy resume the virology 101 series with a discussion of RNA capping, splicing, and export.

Links for this episode:

Slides for this episode (pdf)
Spliced Ad 2 late mRNAs (Cell)
An amazing sequence arrangement (Cell)
Adenovirus late mRNA undecanucleotide (Cell)
Aaron Shatkin, 72 (virology blog)
Schrödinger's cat (Wikipedia)
Letters read on TWiV 216

Weekly Science Picks

Rich - Linus Pauling's explanation of science (YouTube)
Alan - Underwater experiments
Kathy - I'm a virus (YouTube)
Vincent - Stem cells (Bizarro Comics)

Listener Pick of the Week

Tom - The President's Analyst
Danielle - Overly honest methods (HuffPost and ASBMB Today)

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

TWiV 215: Illuminating rabies and unwrapping a SARI

twiv@twiv.tv (Vincent Racaniello) — Sun, 13 Jan 2013 15:47:19 +0000

Hosts: Vincent Racaniello, Alan Dove, and Kathy Spindler

Vincent, Alan, and Kathy review the finding that rabies virus infection alters but does not kill neurons, and provide an update on the novel coronavirus in the Middle East.

Weekly Science Picks

Alan - I'm a Scientist - The Film
Kathy - Humorous units of measurement (Wikipedia)
Vincent - Open access must enable open use (Nature)

Listener Pick of the Week

Tarwin - Plague Inc.

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

TWiV 214: This is your brain on polyomavirus

twiv@twiv.tv (Vincent Racaniello) — Mon, 07 Jan 2013 01:16:44 +0000

Hosts: Vincent Racaniello, Rich Alan Dove, and Kathy Spindler

Vincent, Alan, and Kathy discuss how coagulation factor X binding to adenovirus activates the innate immune system, and a novel polyomavirus associated with brain tumors in raccoons.

Links for this episode:

Coagulation factor X activates innate immunity to adenovirus (Science)
A decorated virus cannot hide (Science)
Reflecting on goals for Science
Polyomavirus associated with raccoon brain tumors (EID)
MPNST
Moore tumor viruses - TWiV 160
Treating CLL with lentivirus vectors (NEJM)
Letters read on TWiV 214

Weekly Science Picks

Alan - Parasite of the Day
Kathy - Tour of International Space Station
Vincent - Earth as Art

Listener Pick of the Week

Robin - Angell on Big Pharma
Michael - Flu jokes
Jim - Database of Ted talks; Downloadable Ted Talks

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

TWiV 213: Not bad for a hobby

twiv@twiv.tv (Vincent Racaniello) — Sun, 30 Dec 2012 23:03:59 +0000

Hosts: Vincent Racaniello, Rich Condit, Alan Dove, and Kathy Spindler

In their final episode of the year, the TWiV team reviews twelve cool virology stories from 2012.

Twelve virology stories from 2012:

H5N1 (TWiV 190, 182, 177, 173, 168)
Polymorphisms that control susceptibility (TWiV 175, 180)
New virus receptors (TWiV 166, 210)
XMRV: Last nail in the coffin (TWiV special)
Polio eradication troubles in Pakistan (NY Times one, two, three; virology blog)
Biomedical research crisis (TWiV 208, 184, 189, 194)
Polydnaviruses in parasitoid wasps (TWiV 179)
Carolyn Coyne’s placental barrier story (TWiV 193)
Touring NEIDL (TWiV 200)
Epidemiology (TWiV 169, 178)
A good year for virus hunting (173, 183, 195, 196, 198, 199, 204)
Pox accordion (TWiV 198)

Weekly Science Picks

Rich - Our Mr. Sun (IMDB entry) (wiki)
Alan - PubReader from NCBI announcement and instructions
Kathy - Popular Mechanics 110 picks for the next 110 years
Vincent - 366 days: Nature's 10

Listener Pick of the Week

Matt - The flu vaccine controversy

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

TWiV Special: Ignorance with Stuart Firestein

twiv@twiv.tv (Vincent Racaniello) — Sat, 29 Dec 2012 00:41:00 +0000

Hosts: Vincent Racaniello and Stuart Firestein

Vincent and Stuart discuss why ignorance - all of what we don't know, and even what we don't know we don't know - is the driving force of science.

Links for this episode:

Ignorance: How it drives Science by Stuart Firestein
Ignorance website

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

TWiV 212: Apocalypse TWiV 122112 212

twiv@twiv.tv (Vincent Racaniello) — Mon, 24 Dec 2012 00:45:16 +0000

Hosts: Vincent Racaniello, Rich Condit, Alan Dove, and Kathy Spindler

The TWiVerers answer listener email about genetically modified chickens, a hendra vaccine for horses, online education, curing color blindness, Roosevelt and polio, Th cells, and much more.

Weekly Science Picks

Rich - Overview
Alan - Notes towards the complete works of Shakespeare
Kathy - Correlation vs. Causation (#1, #2, #3)
Vincent - Periodically inspired

Listener Pick of the Week

Mark - Life of a Nature paper
Ricardo - Things don't go viral

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

TWiV 211: Viruses r us

twiv@twiv.tv (Vincent Racaniello) — Sun, 16 Dec 2012 21:41:26 +0000

Hosts: Vincent Racaniello, Rich Condit, Alan Dove, and Kathy Spindler

The TWiV four discuss an mRNA-based influenza vaccine, and a phage tubulin that forms a filamentous array in the host cell that is needed for positioning viral DNA.

Links for this episode:

mRNA vaccine against influenza (Nat Biotech)
Phage tubulin assembles dynamic filaments (Cell)
Viral skeleton (The Scientist)
Not unorganized bags of enzymes (TWiM 28)
Bacterial cytoskeleton (FEMS Micro Rev)
Triangulation number (jpg)
Letters read on TWiV 211

Weekly Science Picks

Rich - Ocean Global Shark Tracker
Alan - The Field Book Project
Kathy - How to manipulate an army of zombies
Vincent - Science sculpture

Listener Pick of the Week

Stephen - WEHI.TV

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

TWiV 210: Bond, covalent bond

twiv@twiv.tv (Vincent Racaniello) — Sun, 09 Dec 2012 15:45:56 +0000

Hosts: Vincent Racaniello, Rich Condit, Dickson Despommier, Alan Dove, and Kathy Spindler

The complete TWiV team reviews identification of the cell receptor for hepatitis B and D viruses, and the cell enzyme that cleaves the genome-linked protein from picornaviral RNA.

Links for this episode:

HBV and HDV cell receptor (eLIFE)
Getting to grips with hepatitis (eLIFE)
Sodium taurocholate
Poliovirus hijacks DNA repair enzyme (PNAS)
Letters read on TWiV 210

Weekly Science Picks

Rich - Vendée Globe
Dickson - Earth at night
Alan - Trophée Jules Verne
Kathy - Science cookies
Vincent - Trilobite Glassworks

Listener Pick of the Week

Ken - Spanish flu pandemic model (teacher's guide)
Jim - Santa Cruz Science Communication Program (also see SHERP)

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

TWiV 209: When the virus hits the fans

twiv@twiv.tv (Vincent Racaniello) — Sun, 02 Dec 2012 22:53:52 +0000

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler

Vincent, Dickson, Alan, and Kathy answer listener email about deformed wing virus, West Nile virus, FluMist, influenza in Canada, viruses and the tree of life, and more.

Links for this episode:

Postcard from the ultimate student athlete (pdf)
Fidelity of protein synthesis (Biochemistry, 5th ed.)
Letters read on TWiV 209

Weekly Science Picks

Dickson - Cassini web site and Mars reconnaissance orbiter
Alan - OneZoom Tree of Life
Kathy - Viral tumor suppressor structure (Cell)
Vincent - Spot the Station

Listener Pick of the Week

Ricardo - Once upon a time: The possible story of viruses
Jim - Encode, myIDP, Experiment Reproduction podcasts
Mark - MoMath

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

TWiV 208: The biomedical research crisis with Jon Yewdell

twiv@twiv.tv (Vincent Racaniello) — Sun, 25 Nov 2012 22:00:00 +0000

Hosts: Vincent Racaniello and Jon Yewdell

Vincent and is joined by special guest Jon Yewdell to discuss solutions for ending the current crisis in American biomedical research.

Links for this episode:

How to succeed in science: Taking the plunge (Nat Rev Mol Cell Biol)
How to succeed in science: Making discoveries (Nat Rev Mol Cell Biol)
How to succeed in science (YouTube)
Resources for graduate students and postdocs
Science career cartoons by Alexander Dent

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

TWiV 207: Silk sheets and viral infidelity

twiv@twiv.tv (Vincent Racaniello) — Mon, 19 Nov 2012 01:14:20 +0000

Hosts: Vincent Racaniello, Alan Dove, Matt Frieman, and Kathy Spindler

Vincent, Alan, Matt, and Kathy review the use of silk to stabilize antibiotics and a viral vaccine, and an impaired-fidelity vaccine against SARS coronavirus.

Links for this episode:

Silk stabilization of antibiotics and vaccines (PNAS)
Impaired-fidelity coronavirus vaccine (Nature Medicine)
Select agent status and SARS therapies (Spoonful of Medicine)
Letters read on TWiV 207

Weekly Science Picks

Matt - Virus-associated p yramids (slide #11)
Alan - Similarities of wave behavior (YouTube)
Kathy - The glass transition
Vincent - US cattle country in uproar at virus lab plans (BBC)

Listener Pick of the Week

Ricardo - Blackawton bees and Science is for everyone (TED)
Tony - Biophilia by Bjork

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

TWiV #206 - Viral turducken

twiv@twiv.tv (Vincent Racaniello) — Sun, 11 Nov 2012 17:24:58 +0000

Hosts: Vincent Racaniello, Alan Dove, Dickson Despommier, and Kathy Spindler

Vincent, Alan, Dickson, and Kathy discuss how the innate immune response to viral infection influences the production of pluripotent stem cells, and the diverse mobilome of giant viruses.

Links for this episode:

Innate immunity and nuclear reprogramming (Cell)
Viruses affect cell reprogramming (The Scientist)
Cell-penetrating peptides (Trends Mol Med)
Provirophages and transpovirons (PNAS)
Organic Lake photo and map
Letters read on TWiV 206

Weekly Science Picks

Alan - Locust by Jeffery A. Lockwood
Dickson - Nikon Small World Contest 2012
Kathy - Influenza Encyclopedia
Vincent - Dengue fever sweeps India (NY Times)

Listener Pick of the Week

Allison - Fred Guterl on The Daily Show

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv.

TWiV 205: Genetic conflict with Harmit Malik

twiv@twiv.tv (Vincent Racaniello) — Thu, 25 Oct 2012 19:09:00 +0000

Hosts: Vincent Racaniello and Harmit Malik

Vincent is joined by special guest Harmit Malik to discuss his work on the evolution of genetic conflict.

Links for this episode:

Harmit on YouTube
Retroviruses and mammalian placentation (PNAS)
Paleovirology (Curr Opin Virol)
Evolution among AIM2-like receptors (J Exp Med)
Poxvirus genomic accordions (Cell)
Letters read on TWiV 205

Weekly Science Picks

Vincent - Candidates' answers to science questions

Listener Pick of the Week

Steve - Mural of Henrietta Lacks story (Microsoft Silverlight required)

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv.

TWiV 204: M m m my corona

twiv@twiv.tv (Vincent Racaniello) — Sun, 21 Oct 2012 23:03:00 +0000

Hosts: Vincent Racaniello, Alan Dove, Matt Frieman, and Kathy Spindler

Vincent, Alan, Matt and Kathy review isolation of a new coronavirus from two patients in the Middle East, and expansion of the enteric virome during simian AIDS.

Subscribe to TWiV (free) in iTunes, at the Zune Marketplace, by the RSS feed, by email, or listen on your mobile device with the Microbeworld app.

Links for this episode:

Novel coronavirus (virology blog one, two)
PCR assay for novel CoV (Eurosurveillance)
Isolation of novel coronavirus (NEJM)
SARS CoV now a select agent (Federal Register, pdf)
My Sharona
Pathogenic SIV infection associated with expansion of gut virome (Cell)
Letters read on TWiV 204

Weekly Science Picks

Alan - Map of the Wind
Matt - Dark Side of the Earth; Insensitive guide to thriving in your Ph.D.; Gary Vanerchuck (YouTube)
Kathy - How much does a shadow weigh? and Slinky drop answer
Vincent - A Parasite's Parasites; All the cool kids are on arXiv

Listener Pick of the Week

Nissin - Jungle Jim (1948)

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv.

TWiV 203 - Mark Challberg, a cold room kind of guy

twiv@twiv.tv (Vincent Racaniello) — Sun, 14 Oct 2012 23:31:35 +0000

Hosts: Vincent Racaniello, Rich Condit, and Mark Challberg

Vincent and Rich meet up with Mark Challberg to talk about his scientific career studying viral DNA replication, and his transition to an NIH Program Officer.

Subscribe to TWiV (free) in iTunes, at the Zune Marketplace, by the RSS feed, by email, or listen on your mobile device with the Microbeworld app.

Links for this episode:

Purification of vaccinia virus DNA polymerase (J Biol Chem)
Adenovirus DNA replication in vitro (PNAS)
Herpes simplex viral genes required for DNA synthesis (J Virol)
Letters read on TWiV 203

Weekly Science Picks

Rich - Mattel Hot Wheels Curiosity Rover
Vincent - Should H5N1 Moratorium End?

Listener Pick of the Week

Claudio - DIY lab equipment (Ars Technica) and DIY Bio

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv.

TWiV 202 - Huskers go viral

twiv@twiv.tv (Vincent Racaniello) — Sun, 07 Oct 2012 17:19:00 +0000

Hosts: Vincent Racaniello, T. Jack Morris, James Van Etten, and Charles Wood

Vincent travels to the University of Nebraska to meet with members of the Nebraska Center for Virology and discuss their work on algal viruses, plant viruses, HIV and Kaposi's sarcoma herpesvirus.

Links for this episode:

Weekly Science Picks

Charles - Rhabdovirus associated with hemorrhagic fever (PLoS Path)
Vincent - Bacteriophage graffiti (jpg)

Listener Pick of the Week

Bob - Remembering Penny Pinneo
Janet - Penn and Teller on vaccinations (YouTube)

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv.

TWiV 201: Rabid about viruses

twiv@twiv.tv (Vincent Racaniello) — Sun, 30 Sep 2012 16:01:38 +0000

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler

Vincent, Alan, Rich, and Kathy answer reader email about rabies, xenotransplantation, poliovirus, Ph.D. programs, mosquitoes, and much more.

Weekly Science Picks

Alan - Wallace Online
Rich - World Rabies Day
Kathy - Yo-yos in space
Dickson - The Art in Science
Vincent - The Podcasters Studio

Listener Pick of the Week

Wink - DuckDuckGo
Josh - Introduction to Solid State Chemistry

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv.

TWiV 200: Threading the NEIDL

twiv@twiv.tv (Vincent Racaniello) — Sun, 23 Sep 2012 15:03:00 +0000

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Elke Mühlberger, Paul Duprex, and Ron Corley

Vincent, Alan, and Rich celebrate the 200th episode of TWiV by visiting the National Emerging Infectious Diseases Laboratories at Boston University Medical Center, where they meet with Elke, Paul, and Ron to talk about building and working in a BSL4 facility.

Links for this episode:

The NEIDL
NEIDL goes public (BU Today)
Biosafety levels (Wikipedia)
Select agents (Wikipedia)
NEIDL stalled (Boston Business J)
TWiV on Facebook
Letters read on TWiV 200

Weekly Science Picks

Alan - Dance your Ph.D.
Rich - Angel of Death by Gareth Williams
Vincent - Why herpesvirus is good for you (Virgin lab)

Listener Pick of the Week

Luis - VBORNET maps

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv, or call them in to 908-312-0760. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv.

TWiV 200: Threading the NEIDL (video version)

twiv@twiv.tv (Vincent Racaniello) — Sun, 23 Sep 2012 15:00:00 +0000

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Elke Mühlberger, Paul Duprex, and Ron Corley

Links for this episode:

The NEIDL
NEIDL goes public (BU Today)
Biosafety levels (Wikipedia)
Select agents (Wikipedia)
NEIDL stalled (Boston Business J)
TWiV on Facebook
Letters read on TWiV 200

Weekly Science Picks

Alan - Dance your Ph.D.
Rich - Angel of Death by Gareth Williams
Vincent - Why herpesvirus is good for you (Virgin lab)

Listener Pick of the Week

Luis - VBORNET maps

TWiV Special: A paradigm for pathogen de-discovery

twiv@twiv.tv (Vincent Racaniello) — Tue, 18 Sep 2012 16:00:00 +0000

Hosts: Vincent Racaniello and W. Ian Lipkin

Vincent and Ian review a multicenter blinded analysis which finds no association between chronic fatigue syndrome/myalgic encephalomyelitis and XMRV or polytropic murine leukemia virus.

Subscribe to TWiV (free) in iTunes, at the Zune Marketplace, by the RSS feed, by email, or listen on your mobile device with the Microbeworld app.

Links for this episode:

Multicenter blinded analysis of CFS and XMRV/pMLV (mBio)
Press release on multicenter study (pdf)
Press conference webcast
TWiV on Facebook

TWiV 199: Of mice, ticks, and pigs

twiv@twiv.tv (Vincent Racaniello) — Sun, 16 Sep 2012 12:46:53 +0000

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler

Vincent, Alan, Rich, and Kathy discuss recent outbreaks of hantavirus pulmonary syndrome in Yosemite National Park and novel swine-origin influenza in the US midwest, and isolation of the Heartland virus from two patients in Missouri with severe febrile illness.

Subscribe to TWiV (free) in iTunes, at the Zune Marketplace, by the RSS feed, by email, or listen on your mobile device with the Microbeworld app.

Weekly Science Picks

Alan - Insane in the Chromatophores (Vimeo)
Rich - Golden Goose Awards
Kathy - Euler's Disk (YouTube)
Vincent - Ignorance: How it Drives Science by Stuart Firestein

Listener Pick of the Week

Adam - Leigh Van Valen

TWiV 198: Pox has got a squeeze-box, seals are gonna sneeze all night

twiv@twiv.tv (Vincent Racaniello) — Sun, 02 Sep 2012 14:50:13 +0000

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler

Vincent, Alan, Rich, and Kathy review fatal avian influenza virus in harbor seals, and poxvirus deployment of genomic accordions to counter antiviral defenses.

Links for this episode:

Avian influenza virus in harbor seals (mBio)
Poxvirus genomic accordions (mBio)
Red Queen hypothesis (Wikipedia)
TWiV on Facebook
Letters read on TWiV 198

Weekly Science Picks

Alan - Getting Better: 200 Years of Medicine
Rich - Khan Academy
Kathy - Vi Hart
Vincent - Tweet Keeper

Listener Pick of the Week

Diane - The Way We Fall by Megan Crewe
Stephen - Amateur Micrography

TWiV 197: Cloning HeLa cells with Professor Philip I Marcus

twiv@twiv.tv (Vincent Racaniello) — Sun, 26 Aug 2012 14:49:18 +0000

Hosts: Vincent Racaniello and Philip I. Marcus

Vincent travels to the University of Connecticut to meet up with Professor Philip I. Marcus to discuss his development of the single cell cloning technique in the early 1950s.

TWiV 196: An arena for snakes

twiv@twiv.tv (Vincent Racaniello) — Sun, 19 Aug 2012 16:50:39 +0000

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Dickson Despommier, Kathy Spindler, Mark Stenglein, and Joseph DeRisi

The TWiVites meet with Mark Stenglein and Joseph DeRisi to discuss their discovery of a novel arenavirus in snakes with inclusion body disease.

TWiV 195: They did it in the hot tub

twiv@twiv.tv (Vincent Racaniello) — Sun, 12 Aug 2012 19:27:36 +0000

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Dickson Despommier, and Ken Stedman

The complete TWiV team meets with Ken Stedman to discuss the discovery in Boiling Spring Lake of a DNA virus with the capsid of an RNA virus.

Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, by email, or listen on your mobile device with the Microbeworld app.

Links for this episode:

Novel virus from an extreme environment (Biol Direct, virology blog)
Lassen Volcanic National Park
Tombusviridae, Circoviridae (ViralZone)
TWiV on Facebook
Letters read on TWiV 195

Weekly Science Picks

Ken - The Edge of Life trailer and Facebook page
Dickson - The Cognitive Style of Powerpoint by Edward Tufte
Alan - SEMs of insects and spiders via Steve Gschmeissner
Rich - Curiosity Has Landed (Wiki mission summary)
Vincent - Curiosity's Seven Minutes of Terror (YouTube)

Listener Pick of the Week

Lance - The Vaccine Confidence Project and Immune response video (YouTube)
Anat - Beautiful Science

TWiV 194: Five postdocs in North America

twiv@twiv.tv (Vincent Racaniello) — Mon, 06 Aug 2012 03:30:55 +0000

Hosts: Vincent Racaniello, Matthew Daugherty, Jondavid deJong, Helen Lazear, Stefan Oliver, and Cara Pager.

Vincent returns to Madison, Wisconsin and meets with postdocs to discuss their science and their careers.

Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, by email, or listen on your mobile device with the Microbeworld app.

Links for this episode:

TWiV 189: Five postdocs in Glasgow
ASM at the USA Science and Engineering Festival
ASV 2012 at Madison, WI
Photographs of ASV 2012
TWiV on Facebook

TWiV 193: Live at ASV in Madison

twiv@twiv.tv (Vincent Racaniello) — Sun, 29 Jul 2012 13:28:10 +0000

Hosts: Vincent Racaniello, Rich Condit, Carolyn Coyne, and Sara Sawyer

Vincent, Rich, Carolyn, and Sara recorded TWiV at the 31st Annual Meeting of the American Society for Virology in Madison, where they discussed genetic conflict between viral and human genes, and how the placenta protects the fetus against viral infection.

Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, by email, or listen on your mobile device with the Microbeworld app.

Links for this episode:

ASV 2012 at Madison, WI
Photographs of ASV 2012
Rock band Herpetic Legion plays at ASV 2012
TWiV on Facebook
Letters read on TWiV 193

Weekly Science Picks

Rich - Benjamin Franklin: An American Life by Walter Isaacson
Vincent - Biochemistry Revealed

Listener Pick of the Week

Matlock - The BioDigital Human
Matt - Scientists create jellyfish from rat cells

TWiV 192: Viral tertulia

twiv@twiv.tv (Vincent Racaniello) — Sun, 22 Jul 2012 19:47:45 +0000

Hosts: Vincent Racaniello, Alan Dove, and Rich Condit

Vincent, Alan, and Rich answer listener email about bioinformatics, insects, influenza, laboratory classes, commensalism, reproducibility of data, and more.

Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, by email, or listen on your mobile device with the Microbeworld app.

Links for this episode:

Vaccinia virus sequence from patient with vaccine complication (pdf)
The evolution of intellectual freedom (thanks, Robin!)
Free access to British scientific research (Guardian)
xTAG respiratory viral panel
Houston rabies case (Statesman)
Tertulia (Wikipedia)
TWiV on Facebook
Letters read on TWiV 192

Weekly Science Picks

Alan - The Microbial Olympics (supplementary information)
Rich - PharmaJet needle free injection system
Vincent - Microbes and Evolution by Roberto Kolter and Stanley Maloy (paperback and Kindle)

Listener Pick of the Week

Varun - Agile Gene by Matt Ridley
Sizun - Plague Inc
Ricardo - TED-ED
Kristopher - Ed Yong on Econtalk

TWiV 191: When two rights make a wrong

twiv@twiv.tv (Vincent Racaniello) — Sun, 15 Jul 2012 16:34:00 +0000

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Nissin Moussatche

Nissin joins the TWiV crew to discuss an outbreak of lethal disease among Cambodian children, and recombination among attenuated herpesvirus vaccines leading to pathogenic viruses.

Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, by email, or listen on your mobile device with the Microbeworld app.

Weekly Science Picks

Alan - H5N1 genetic changes inventory
Rich - Mythbusters: Diet Coke and Mentos (YouTube channel)
Nissin - The Pox and the Covenant by Tony Williams, and Tired of War by Tereza Batista
Vincent - FAQ: The 'snake bite' portion of your thesis defense

Listener Pick of the Week

Gopal - All's not fair in science and publishing
Luis - The Origin of AIDS by Jacques Pepin (Nature review)
Sven - Visualizing information flow in science

TWiV 190: The second ferret of the Apocalypse

twiv@twiv.tv (Vincent Racaniello) — Sun, 01 Jul 2012 14:30:47 +0000

Hosts: Vincent Racaniello, Alan Dove, and Kathy Spindler

Vincent, Alan, and Kathy review selection of influenza H5N1 viruses that can transmit among ferrets by aerosol.

Links for this episode:

Airborne transmission of H5N1 among ferrets (Science)
Potential for H5N1 evolution (Science)
H5N1 (Science)
The ferrets of fear
Jim's podcast list (pdf)
TWiV on Facebook
Letters read on TWiV 190

Weekly Science Picks

Kathy - Wind map
Vincent - The A-Z of Epidemiology (YouTube)

Listener Pick of the Week

Kristoffer - How to read a paper
Neva - Electricity from viruses

TWiV 189: Five postdocs in Glasgow

twiv@twiv.tv (Vincent Racaniello) — Sun, 24 Jun 2012 19:45:00 +0000

Vincent returns to the Centre for Virus Research at the University of Glasgow and meets with postdocs to discuss their science and their careers.

Links for this episode:

MRC-University of Glasgow Centre for Virus Research
Stop CMV
Photos of my Glasgow visit (Facebook and VirusTalk)
TWiV on Facebook

TWiV 188 - Haggis, single malt, and viruses

twiv@twiv.tv (Vincent Racaniello) — Fri, 15 Jun 2012 21:20:00 +0000

Hosts: Vincent Racaniello, Massimo Palmarini, John MacLauchlan, Emma Thomson, and Hande Harmanci.

Vincent travels to Scotland to meet with members of the Centre for Virus Research at the University of Glasgow to discuss their work on hepatitis C virus and jaagsiekte sheep retrovirus.

Links for this episode:

MRC-University of Glasgow Centre for Virus Research
Aaron Shatkin, 77 (virology blog)
Photos of my Glasgow visit (Facebook and VirusTalk)
TWiV on Facebook
Letters read on TWiV 188

Weekly Science Picks

Vincent - Microbe art

Listener Pick of the Week

Judi - Cell Imaging (Mac App Store)

TWiV 187: The mummy

twiv@twiv.tv (Vincent Racaniello) — Mon, 11 Jun 2012 01:47:00 +0000

Hosts: Vincent Racaniello and Rich Condit

Vincent and Rich discuss recovery of a hepatitis B viral genome from a 16th century Korean mummy, and personal omics profiling of an individual over a 14 month period.

Weekly Science Picks

Rich - The Checklist by Atul Gawande
Vincent - Artologica

Listener Pick of the Week

David - Cracking your genetic code (Nova)
Josh - The nuclearization of biology is a threat to health and security (pdf)

TWiV 186: From Buda to stump grinding

twiv@twiv.tv (Vincent Racaniello) — Sun, 03 Jun 2012 16:25:00 +0000

Hosts: Vincent Racaniello, Alan Dove, and Rich Condit

The TWiV chiefs tackle reader email about how to pronounce Buda, Texas, grinding tree stumps, and much more.

Links for this episode:

Detecting antibodies or antigens by ELISA
Peter Wildy Prize
Biosafety levels
Baltimore classification at Viral Zone
TWiV on Facebook
Letters read on TWiV 186

Weekly Science Picks

Alan - World Wide Lightning Location Network
Rich - Steve Jobs by Walter Isaacson
Vincent - The Ocelloid

Listener Pick of the Week

lafrenchfille - whatshouldwecallgradschool
Neva - Antiviral drugs by Carl Zimmer
Sergio - APSnet

TWiV 185: Dead parrots and live Wildcats

twiv@twiv.tv (Vincent Racaniello) — Sun, 27 May 2012 21:07:00 +0000

Vincent visits with members of the Department of Microbiology and Immunology at Northwestern University School of Medicine to discuss their work on herpesviruses and parainfluenzaviruses.

Links for this episode:

Longnecker laboratory
Herpesvirus deubiquitinase is neuroinvasive determinant (PLoS Path)
Paramyxovirus HN structure (PNAS)
TWiV on Facebook
Letters read on TWiV 185

Weekly Science Picks

Sarah - Breasts: A Natural and Unnatural History by Florence Williams
Andrew - The Strangest Man by Graham Farmelo
Vincent - Gates Grand Challenges in Global Health awards

Listener Pick of the Week

Ed - Pursuit of Light (YouTube); MRC Biomedical Picture of the Day; It's okay to be smart

TWiV 184: Reforming science

twiv@twiv.tv (Vincent Racaniello) — Sun, 20 May 2012 14:07:52 +0000

Vincent, Rich, and Alan consider how to reform the scientific enterprise to make it more effective and robust.

Links for this episode:

Reforming science: Methodological and cultural reforms (Infect Immun)
Reforming science: Structural reforms (Infect Immun)
Sharp rise in retractions (NY Times)
Vannevar Bush
TWiV on Facebook
Letters read on TWiV 184

Weekly Science Picks

Alan - PubMed PubReMiner
Rich - Intentional Blindness (YouTube)
Vincent - Vaccine infographic

Listener Pick of the Week

Ken - Wattpad

TWiV 183: Bats out of hell

twiv@twiv.tv (Vincent Racaniello) — Sun, 13 May 2012 14:11:56 +0000

Connor joins the TWiV team to discuss bats as hosts for major mammalian paramyxoviruses.

Links for this episode:

NIH response to Osterholm letter (pdf)
Who's afraid of the big, bad bioterrorist?
Bats host major mammalian paramyxoviruses (Nature Comm)
TWiV on Facebook
Letters read on TWiV 183

Weekly Science Picks

Connor - Microbiology Twitter journal club
Alan - Where the Wild Types Are (YouTube)
Rich - May 14th: Smallpox vaccination day
Dickson - Searching for pore-fection (Science)
Vincent - RRResearch

Listener Pick of the Week

Stephen - Every Major's Terrible (xkcd)

TWiV 182: One flu over the ferrets' nest

twiv@twiv.tv (Vincent Racaniello) — Sun, 06 May 2012 13:45:25 +0000

Hosts: Vincent Racaniello, Rich Condit, Alan Dove, and Michael J. Imperiale

Michael joins the TWiV crew to discuss the recently published influenza H5N1 transmission paper and how it was viewed by the NSABB.

Links for this episode:

About the NSABB
The Kawaoka paper (Nature)
Mutant flu paper published (Ed Yong)
Osterholm letter (pdf)
US policy for dual research of concern (pdf)
TWiV on Facebook
Letters read on TWiV 182

Weekly Science Picks

Alan - 18th century shipping mapped
Rich - Brave New World by Aldous Huxley
Vincent - Air France 447 (Telegraph)

Listener Pick of the Week

Josh - Vaccines course by Dr. Paul Offit

TWiV 181: ORFan poxviruses and nIRFing prions

twiv@twiv.tv (Vincent Racaniello) — Sun, 29 Apr 2012 13:31:04 +0000

Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler

Vincent, Rich, and Kathy discuss Cotia virus, a new poxvirus, Orf virus infections associated with handling goats and lamb, and the innate immune response to prions.

Weekly Science Picks

Kathy - Astronomy Picture of the Day (especially this and this)
Rich - Tom Lehrer Element Song (YouTube)
Vincent - Albert B. Sabin Archives

Listener Pick of the Week

Mark - Netter's Infectious Diseases by Elaine C. Jong and Dennis L. Stevens
Richard - Germs, Genes & Civilization by David P. Clark

TWiV 180: Throwing IFIT at flu and holding a miR to HCV

twiv@twiv.tv (Vincent Racaniello) — Sun, 22 Apr 2012 13:36:37 +0000

Hosts: Vincent Racaniello, Alan Dove, and Rich Condit

Vincent, Alan, and Rich review association of an interferon-induced protein with severe influenza, and stabilization of HCV RNA by a microRNA.

Links for this episode:

IFITM3 and severe influenza (Nature)
Genetics of flu susceptibiligy (EurekAlert!)
Stabilization of HCV RNA by Ago2-miR-122 (PNAS)
Clinical trial of anti-mIR-122
TWiV on Facebook
Letters read on TWiV 180

Weekly Science Picks

Alan - Micro Empire (Vimeo)
Rich - Census of marine life
Vincent - Pinterest

Listener Pick of the Week

Mark - The Secret Life of Plankton (YouTube)

TWiV 179: Was ist ein virus?

twiv@twiv.tv (Vincent Racaniello) — Sun, 15 Apr 2012 18:27:58 +0000

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Gertrud Radu

Gertrud joins the TWiVoners to review how dengue virus infection of mosquitoes alters blood feeding behavior, and gene therapy as practiced by parasitoid wasps.

Links for this episode:

Renato Dulbecco, 1914-2012 (virology blog)
William Jarrett, 83 (thanks, Lynn Enquist)
Dengue virus infection of mosquitoes alters their behavior (PLoS Path)
Does dengue make mosquitoes thirstier for blood? (NY Times)
Polydnaviruses of braconid wasps (Science)
Making nice with viruses (Science)
Viral and wasp genes involved in symbiotic replication (J Virol)
Amazing parasitic wasp images
The Far Side cartoon on mosquitoes (gif)
TWiV on Facebook
Letters read on TWiV 179

Weekly Science Picks

Gertrud - Bat on a plane! (MMWR)
Alan - The Rings of Earth (YouTube)
Rich - Giant Magellan telescope
Vincent - Hepatitis C new drug pipeline

Listener Pick of the Week

Ricardo - Evolution: The Natural History of Animal Skeletons
Peter - Self-assembly line (YouTube)

TWiV 178: T-Sharp on how tequila mosquito

twiv@twiv.tv (Vincent Racaniello) — Sun, 08 Apr 2012 15:26:05 +0000

The TWiValians meet up with Tyler Sharp for a discussion on the Epidemic Intelligence Service and controlling dengue.

Links for this episode:

2010 dengue epidemic in Puerto Rico
Marshall Islands dengue outbreak (one and two)
Photo of Tyler by Loren Rodgers
TWiV shout-out by NPR and CIDRAP
NSABB reverses decision on H5N1 publication
TWiV on Facebook
Letters read on TWiV 178

Weekly Science Picks

Tyler - Co-infection with dengue and Leptospira (Emerging Inf Dis)
Alan - The Winged Scourge (YouTube)
Rich - Deepsea Challenge
Vincent - Why did a US advisory board reverse its stance? (Ed Yong)

Listener Pick of the Week

Sasha - Microfluidic Future
Adam - The Conversation
Jim - ENIAC Programmers Project

TWiV 177: Live in Dublin

twiv@twiv.tv (Vincent Racaniello) — Sun, 01 Apr 2012 13:48:55 +0000

A discussion of avian influenza H5N1 transmission experiments in ferrets and novel bunyaviruses at the 2012 Spring Conference of the Society for General Microbiology in Dublin, Ireland.

Links for this episode:

Restricted data on H5N1 transmission (Science)
Novel bunyavirus in China (NEJM and TWiV 127)
Ten things about Schmallenberg virus (Microbiology Bytes)
NSABB reverses decision on H5N1 papers (virology blog)
TWiV on Facebook
Letters read on TWiV 177

Weekly Science Picks

Connor - Wellcome Trust Science Writing Prize 2012
Vincent - Thoughts on academic scientists giving media interviews

TWiV 176: Ave, magi virorum!

twiv@twiv.tv (Vincent Racaniello) — Sat, 24 Mar 2012 02:31:00 +0000

Vincent, Alan, and Rich answer listener email about MS, CFS, EBV, B cells, virii, influenza B, scientific papers, and more.

Weekly Science Picks

Rich - Alan Alda's Flame Challenge (NY Times article, Science editorial)
Alan - ChronoZoom
Vincent - Academic Publishing is Broken by Michael P. Taylor

Listener Pick of the Week

Joel - Fighting a dengue outbreak by Tyler M. Sharp (parts one and two)
Sven-Urban - Fooled by Randomness and The Black Swan by Nassim Nicholas Taleb

TWiV 175: More than one way to skin a virus

twiv@twiv.tv (Vincent Racaniello) — Sun, 18 Mar 2012 22:21:31 +0000

Vincent, Alan, and Matt discuss herpes simplex encephalitis in children with innate immune deficiency, and the local response to microneedle-based influenza skin immunization.

Links for this episode:

Herpes encephalitis in children with TRIF deficiency (J Clin Inv)
Toll-like receptor and cytosolic pattern recognition receptors
Skin responses to influenza microneedle vaccine (mBio)
Microneedles
Fluzone intradermal influenza vaccine
QDot nanocrystal technology
TWiV on Facebook
Letters read on TWiV 175

Weekly Science Picks

Matt - Phage and the Origins of Molecular Biology
Alan - Digital Imagine Institute
Vincent - iPad apps Goodreader and Notability

Listener Pick of the Week

Jane -Smoking Ears and Screaming Teeth by Trevor Norton

TWiV 174: Dog runs and mooing miRs

twiv@twiv.tv (Vincent Racaniello) — Sun, 11 Mar 2012 16:06:00 +0000

Hosts: Vincent Racaniello, Alan Dove, and Rich Condit

Vincent, Alan, and Rich consider whether pet dogs might transmit human noroviruses, and an RNA virus microRNA that might be involved in oncogenesis.

Weekly Science Picks

Rich - NOAA Buoy Data
Alan - Autism's False Prophets by Paul Offit
Vincent - Media Mining

Listener Pick of the Week

Mark - How the West fueled the AIDS epidemic
Henry - Regenesis
Rick - Biopunk: DIY scientists hack the software of life by Marcus Wohlsen

TWiV 173: Going to bat for flu research

twiv@twiv.tv (Vincent Racaniello) — Sun, 04 Mar 2012 22:05:00 +0000

The TWiVites discuss seroevidence for human infection with avian influenza H5N1, and the discovery of a new influenza virus in Guatemalan bats.

Links for this episode:

Seroevidence for human H5N1 infection (Science)
Mammalian-transmissible H5N1 (mBio)
New information about ferret-adapted H5N1 (NY Times, virology blog)
New influenza virus from fruit bats (PNAS)
Elsevier abandons open access assault (The Scientist)
Le virus le plus dangereux?
TWiV on Facebook
Letters read on TWiV 173

Weekly Science Picks

Ashlee – AskScience (Reddit)
Michael - HealthMap (iPhone and Android app)
Rich – H5N1 research discussion at ASMBiodefense
Alan – El Yunque National Forest
Vincent – The Journal of Global Health

Listener Pick of the Week

Judi – NSF visualization challenge

TWiV 172: Two can be as bad as one

twiv@twiv.tv (Vincent Racaniello) — Mon, 27 Feb 2012 00:02:08 +0000

Hosts: Vincent Racaniello and Kathy Spindler

Vincent and Kathy discuss how a virus may cause disease distant from its replication site, then review a day in the life of a senior microbiology professor.

Links for this episode:

Celsius vs Centigrade
Neuropathogenesis during polymicrobial infection (PLoS Pathogens)
Tetramer staining (pdf)
One
TWiV on Facebook
Letters read on TWiV 172

TWiVspecial2.mp3

twiv@twiv.tv (Vincent Racaniello) — Sun, 19 Feb 2012 22:27:09 +0000

TWiV 171: One is the loneliest number

twiv@twiv.tv (Vincent Racaniello) — Sun, 19 Feb 2012 15:49:33 +0000

Matt joins the TWiVarians to review virus production in single cells and single virion genomics.

Links for this episode:

H5N1 results will be published (NY Times)
Virus production in single cells then and now
Single virion genomics (PLoS One)
Multiple displacement amplification (Wikipedia)
Ranavirus killing turtles, tadpoles in Maryland (Washington Post)
Three Dog Night
TWiV on Facebook
Letters read on TWiV 171

TWiV 170: From variolous effluvia to VLPs

twiv@twiv.tv (Vincent Racaniello) — Sun, 12 Feb 2012 19:51:00 +0000

Alan, Rich, and Dickson discuss Edward Jenner's paper on cowpox vaccine, then move 200 years later to modern vaccines against norovirus, influenza H5N1, and more.

TWiV 169: Epidemiology causes conclusions (p<0.05)

twiv@twiv.tv (Vincent Racaniello) — Sun, 05 Feb 2012 22:47:31 +0000

Michael and the TWiV team review epidemiology basics, including fatality ratios.

Links for this episode:

Michael's blog and podcast
Epidemiology literature critique (PowerPoint)
Seven mistakes in epidemiology (ETE)
Snow cholera map
TWiV on Facebook
Letters read on TWiV 169

TWiV 168: Super CalTech prophylaxis and ferret runny noses

twiv@twiv.tv (Vincent Racaniello) — Sun, 29 Jan 2012 22:07:05 +0000

Welkin joins the TWiV team for a discussion of HIV prophlaxis using vectored antibodies, and the influenza H5N1 virus studies in ferrets that were not redacted.

Links for this episode:

Vectored HIV immunoprophylaxis (Nature)
Vectored immunoprophylaxis - the Movie (YouTube)
Adeno-associated virus (Wikipedia)
In vitro evolution of H5N1 towards human receptor specificity (Virology)
Endogenous viral genes non-essential in chicken (Nature)
Rates of HIV transmission per coital act (J Inf Dis)
TWiV on Facebook
Letters read on TWiV 168

TWiV 167: It starts with a cough

twiv@twiv.tv (Vincent Racaniello) — Sun, 22 Jan 2012 16:32:00 +0000

The complete TWiVome deconstructs the movie Contagion.

TWiV 166: Breaking and entering

twiv@twiv.tv (Vincent Racaniello) — Sun, 15 Jan 2012 16:41:37 +0000

Vincent, Dickson, Rich, and Alan review cell proteins essential for entry of hepatitis C, Ebola, and measles viruses.

Links for this episode:

Niemann-Pick C1 is entry factor for HCV (Nature Med)
Ebola virus entry requires Niemann-Pick C1 (Nature one, two)
Nectin-4 is measles virus epithelial receptor (Nature, PLoS Pathogens)
An exit strategy for measles virus (Science)
On this day in history
TWiV on Facebook
Letters read on TWiV 166

TWiV 165: The email zone

twiv@twiv.tv (Vincent Racaniello) — Sun, 08 Jan 2012 04:12:00 +0000

Vincent, Dickson, Rich, and Alan answer listener questions about XMRV, cytomegalovirus, latency, shingles vaccine, myxomavirus and rabbits, and more.

TWiV 164: Six steps forward, four steps back

twiv@twiv.tv (Vincent Racaniello) — Sun, 01 Jan 2012 20:28:35 +0000

Vincent, Alan, and Rich review ten compelling virology stories of 2011.

TWiV 163: What Rous wrought

twiv@twiv.tv (Vincent Racaniello) — Sun, 25 Dec 2011 20:16:39 +0000

Vincent, Dickson, Rich, and Alan review the 100 year old finding by Peyton Rous of a transmissible sarcoma of chickens, a discovery that ushered in the era of tumor virology.

TWiV 162: Transcription

twiv@twiv.tv (Vincent Racaniello) — Sun, 18 Dec 2011 17:56:00 +0000

Vincent, Rich, and Alan continue Virology 101 with a discussion of transcription, the process of making mRNA from a DNA template.

TWiV #161 - Concerto in B

twiv@twiv.tv (Vincent Racaniello) — Sun, 11 Dec 2011 17:49:09 +0000

Vincent, Rich, Alan and Gabriel review the production of antibodies by B cells, and how high affinity antibodies are selected in the germinal centers of lymph nodes.

TWiV #160 - Moore tumor viruses

twiv@twiv.tv (Vincent Racaniello) — Sun, 04 Dec 2011 16:22:57 +0000

The TWiV team speaks with Patrick Moore about his discovery, with Yuan Chang, of two human tumor viruses, Kaposi's sarcoma herpesvirus and Merkel cell polyomavirus.

TWiV #159 - Flu gets the REDD light

twiv@twiv.tv (Vincent Racaniello) — Sun, 27 Nov 2011 20:04:00 +0000

Vincent, Alan, and Rich review concern over an influenza H5N1 transmission experiment, and a new host defense protein against RNA viruses.

TWiV #158 - Wolverines go viral

twiv@twiv.tv (Vincent Racaniello) — Sun, 20 Nov 2011 20:40:20 +0000

Vincent and Rich visit the Microbiology and Immunology Department at the University of Michigan Medical School, and speak with Alice and Kathy about their work on HIV genome dimerization, and packaging and pathogenesis of mouse adenovirus.

TWiV #157 - Better innate than never

twiv@twiv.tv (Vincent Racaniello) — Mon, 14 Nov 2011 03:19:41 +0000

A large TWiV panel remembers Ralph Steinman, and considers a new innate sensor of retroviral capsids.

TWiV #156 - Armed and targeted killer meta-analysis

twiv@twiv.tv (Vincent Racaniello) — Sat, 05 Nov 2011 21:22:00 +0000

Vincent, Rich, and Dickson review a meta-analysis on influenza vaccine, a killer virus in fungi that selects against RNAi, and the use of armed and targeted poxviruses for oncolytic virotherapy.

TWiV #155 - XXII Brazilian National Virology Meeting

twiv@twiv.tv (Vincent Racaniello) — Sun, 30 Oct 2011 18:28:00 +0000

Vincent, Grant, Eurico, Paulo, Francisco and Janice discuss their work on bocavirus, infectious bronchitis virus, begamoviruses, and circoviruses at the Brazilian Virology Society meeting in Atibaia, São Paulo, Brazil.

TWiV #154 - Symbiotic safecrackers

twiv@twiv.tv (Vincent Racaniello) — Sat, 22 Oct 2011 02:32:00 +0000

Vincent, Alan, and Rich are very enthusiastic about two studies that show how gut bacteria help viral invaders.

TWiV #153 - Rabid reindeer and protective prions

twiv@twiv.tv (Vincent Racaniello) — Sun, 16 Oct 2011 16:47:19 +0000

Vincent, Alan, and Rich review an outbreak of rabies in arctic foxes and reindeer in Norway, and a prion that makes you go antiviral.

TWiV #152 - Viromes in the effluence of society

twiv@twiv.tv (Vincent Racaniello) — Sun, 09 Oct 2011 18:33:18 +0000

Vincent, Alan, and Rich cover the virome of raw sewage, and a baculovirus gene that causes caterpillars to climb to their doom.

TWiV #151 - Dear TWiVers

twiv@twiv.tv (Vincent Racaniello) — Sun, 02 Oct 2011 15:45:52 +0000

Vincent, Alan, and Rich review questions and comments from TWiV listeners.

TWiV #150 - Contaminated

twiv@twiv.tv (Vincent Racaniello) — Sat, 24 Sep 2011 22:09:00 +0000

Vincent, Dickson, and Rich meant to do an all-email episode, but first they review results of the Blood XMRV Scientific Research Working Group, and partial retraction of the paper associating XMRV with chronic fatigue syndrome.

TWiV 148: Retreating into Harvard virology (Video)

twiv@twiv.tv (Vincent Racaniello) — Thu, 22 Sep 2011 12:12:00 +0000

Hosts: Vincent Racaniello, Philip Kranzusch, David Knipe, and Priscilla Yang

Vincent, Philip, David, and Priscilla recorded this episode before an audience at the Harvard Virology Program Annual Retreat, where they discussed negative strand RNA viruses, a vaccine against herpes simplex virus type 2, lipidomics of viral infection, and science communication.

The Keynote Speaker at the Harvard Virology retreat is usually an individual, but this year the honor went to TWiV as an example of science communication to the public. Many thanks to members of the Virology Program for a terrific retreat!

Artwork by Silvia Piccinotti, G4

Right-click to download TWiV 148 (56 MB .mp3, 77 minutes).

Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, by email, or listen on your mobile device with the Microbeworld app.

Weekly Science Picks

Philip - AntWeb
David - Herpes-like viruses in corals (PNAS and LiveScience)
Priscilla - Science museums (Boston, Durham)
Vincent - Contagion

Listener Pick of the Week

Jenny - Emerman's review of Planet of Viruses (PLoS Biology)

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv , or call them in to 908-312-0760. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv.

TWiV #149 - Live at ICAAC in the Windy City

twiv@twiv.tv (Vincent Racaniello) — Sat, 17 Sep 2011 23:35:00 +0000

Vincent, Rich, Mark, and Trine discuss science and medicine in journalism and the eradication of poliovirus at the 51st Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC).

TWiV #148 - Retreating into Harvard virology

twiv@twiv.tv (Vincent Racaniello) — Sun, 11 Sep 2011 22:30:00 +0000

TWiV #147 - Debugging dengue

twiv@twiv.tv (Vincent Racaniello) — Sun, 04 Sep 2011 14:30:40 +0000

The complete TWiV gang discusses the use of Wolbachia to control mosquito-borne infections.

TWiV #146 - Draco's potion

twiv@twiv.tv (Vincent Racaniello) — Sun, 28 Aug 2011 20:21:56 +0000

Vincent, Rich, and Abbie review a broad spectrum antiviral protein, and selective pressure applied by a failed HIV-1 vaccine.

TWiV #145 - The inVinceable TWiV

twiv@twiv.tv (Vincent Racaniello) — Tue, 16 Aug 2011 22:19:49 +0000

Alan and Rich tackle the discovery of bacteriophages, and treating influenza by calming the cytokine storm.

TWiV #144 - HIV gets the (zinc) finger

twiv@twiv.tv (Vincent Racaniello) — Sun, 31 Jul 2011 15:08:43 +0000

Vincent, Rich, and Alan discuss live blogging of scientific meetings, the current outbreak of Hendra virus is Australia, and using zinc finger nucleases to make HIV-resistant CD4 cells.

TWiV #143 - Live at ASV in Minneapolis

twiv@twiv.tv (Vincent Racaniello) — Sun, 24 Jul 2011 15:43:41 +0000

Vincent, Rich, Julie and Stacey recorded TWiV at the 30th Annual Meeting of the American Society for Virology in Minneapolis, where they discussed the role of neutralizing antibodies in protection against HIV-1 infection, and astroviruses, agents of gastroenteritis.

TWiV #142 - Viral oinkotherapy

twiv@twiv.tv (Vincent Racaniello) — Sun, 17 Jul 2011 12:24:28 +0000

Vincent, Rich, and Alan discuss a method for identifying viruses of individual environmental bacteria, and the using a picornavirus for oncotherapy.

TWiV #141 - Mickey gets HCV

twiv@twiv.tv (Vincent Racaniello) — Sun, 10 Jul 2011 15:31:27 +0000

Matt Evans joins Vincent, Dickson, Alan, and Rich to deconstruct a mouse model for hepatitis C virus infection.

TWiV #140 - An aptitude for microbicides

twiv@twiv.tv (Vincent Racaniello) — Sun, 03 Jul 2011 16:34:48 +0000

Vincent, Alan, Rich, and Judy Lieberman review the use of CD4 aptamer-siRNA chimeras to inhibit HIV transmission.

TWiV #139 - Honey, I shrunk the virus

twiv@twiv.tv (Vincent Racaniello) — Sun, 26 Jun 2011 18:14:34 +0000

Vincent, Alan, and Dickson discuss the reduction in genome size of Mimivirus upon passage in amoeba, and analysis of the microbiome of honeybees.

TWiV #138 - RISCy business with Raul Andino

twiv@twiv.tv (Vincent Racaniello) — Sun, 19 Jun 2011 18:03:03 +0000

Vincent meets up with Raul Andino in San Francisco to discuss the RNAi-based antiviral defense system of Drosophila, the fruit fly, and how it is antagonized by viruses.

TWiV #137 - Look what the dog dragged in

twiv@twiv.tv (Vincent Racaniello) — Sun, 12 Jun 2011 22:35:54 +0000

The TWiV team speaks with Amit Kapoor and Ian Lipkin about how they discovered canine hepacivirus, and its implications for the origin and evolution of hepatitis C virus.

TWiV #136 - Exit XMRV

twiv@twiv.tv (Vincent Racaniello) — Mon, 06 Jun 2011 02:55:45 +0000

Retrovirologist Stephen Goff joins Vincent, Rich, and Alan for a discussion of recent papers on the retrovirus XMRV and its association with chronic fatigue syndrome and prostate cancer.

TWiV #135 - Live in the Big Easy

twiv@twiv.tv (Vincent Racaniello) — Sun, 29 May 2011 18:40:30 +0000

Vincent and guests Rachel Katzenellenbogen, Roger Hendrix, and Harmit Malik recorded TWiV #135 live at the 2011 ASM General Meeting in New Orleans, where they discussed transformation and oncogenesis by human papillomaviruses, the amazing collection of bacteriophages on the planet, and the evolution of genetic conflict between virus and host.

TWiV #134 - Meet Ralph, your cruise director

twiv@twiv.tv (Vincent Racaniello) — Sun, 22 May 2011 14:47:50 +0000

Vincent, Rich, Alan, and Dickson review noroviruses with Stephanie Karst, PhD.

TWiV #133 - The HIV hideout

twiv@twiv.tv (Vincent Racaniello) — Sun, 15 May 2011 20:39:00 +0000

Vincent, Rich, Alan, and Dickson discuss the cellular reservoir of HIV-1 with Kathleen Collins, MD, PhD.

TWiV #132 - Virology 911

twiv@twiv.tv (Vincent Racaniello) — Mon, 09 May 2011 00:13:00 +0000

Vincent, Rich, Alan, and Dickson speak with Alfred Sacchetti, MD, Chief of Emergency Services at Our Lady of Lourdes Medical Center, about viral infections encountered in the emergency room.

TWiV #131 - A REOstat for cancer

twiv@twiv.tv (Vincent Racaniello) — Sun, 01 May 2011 18:43:03 +0000

Vincent, Alan, and Dickson chat with Brad Thompson, CEO of Oncolytics Biotech, about using reovirus to treat cancer.

TWiV #130 - Rhino tracking, wrestling pox, and HCV in the crosshairs

twiv@twiv.tv (Vincent Racaniello) — Sun, 24 Apr 2011 14:34:41 +0000

Vincent, Alan, and Rich discuss growth in culture of newly identified rhinovirus C, vaccinia transmission among wrestlers and martial artists, and results of phase III clinical trial of boceprevir, a new inhibitor of hepatitis C virus replication.

TWiV #129 - We've got mail

twiv@twiv.tv (Vincent Racaniello) — Sun, 17 Apr 2011 15:43:09 +0000

Vincent, Alan, Dickson and Rich answer listener questions about XMRV, yellow fever vaccine, virus-like particles, West Nile virus, amyotrophic lateral sclerosis and human endogenous retroviruses, multiplicity of infection, and how to make a poxvirus.

TWiV #128 - Virologists in the mist

twiv@twiv.tv (Vincent Racaniello) — Sun, 10 Apr 2011 14:38:32 +0000

Vincent, Alan, Dickson and Welkin review how a virus regulates the severity of mucocutaneous leishmaniasis, virophage control of antarctic algal host-virus dynamics, and human metapneumovirus infection in gorillas.

TWiV #127 - Viruses are no joke

twiv@twiv.tv (Vincent Racaniello) — Sun, 03 Apr 2011 18:50:20 +0000

Vincent, Alan, and Rich explore a novel bunyavirus isolated in China, the recent polio outbreak in Republic of the Congo, and cell to cell transmission of a retrovirus by biofilm-like extracellular assemblies.

TWiV #126 - Wart's up, doc?

twiv@twiv.tv (Vincent Racaniello) — Sun, 27 Mar 2011 15:39:53 +0000

Virologist Michelle Ozbun and the TWiV team review the biology of human papillomaviruses.

TWiV #125 - TWiV infects FiB

twiv@twiv.tv (Vincent Racaniello) — Sun, 20 Mar 2011 15:39:44 +0000

This Week in Virology and Futures in Biotech join together in a science mashup to talk about a virophage at the origin of DNA transposons, and unintended spread of a recombinant retrovirus.

TWiV #124 - Viruses that make you better

twiv@twiv.tv (Vincent Racaniello) — Sun, 13 Mar 2011 12:41:29 +0000

Vincent, Dickson, Alan, Rich, and Grant discuss a tanapoxvirus protein that inhibits tumor necrosis factor, purging tumors with myxoma virus, and destruction of the last known stocks of smallpox virus.

TWiV #123 - Contaminated prostates, absolute truth, and bleached worms

twiv@twiv.tv (Vincent Racaniello) — Sun, 06 Mar 2011 18:03:00 +0000

Vincent, Alan, and Rich talk about XMRV integration sites in prostate tumor DNA, the decline effect and scientific method, and the first virus of Caenorhabditis nematodes.

TWiV #122 - More fun than a monkey full of viruses

twiv@twiv.tv (Vincent Racaniello) — Sun, 27 Feb 2011 15:19:56 +0000

The complete TWiV crew teams up with Welkin Johnson to explore the other AIDS epidemic, infection of monkeys with simian immunodeficiency virus, and its restriction by the cellular protein TRIM5.

TWiV 121 video

twiv@twiv.tv (Vincent Racaniello) — Mon, 21 Feb 2011 13:47:00 +0000

TWiV #121 - Huskies go viral

twiv@twiv.tv (Vincent Racaniello) — Sun, 20 Feb 2011 23:05:00 +0000

A conversation about careers in virology, systems biology, innate immunity, and antiviral research recorded at the University of Washington in Seattle.

TWiV #120 - Ed Niles, a Km Vmax kind of guy

twiv@twiv.tv (Vincent Racaniello) — Sun, 13 Feb 2011 13:23:00 +0000

Vincent, Rich, and Ed discuss the transition from academic scientist to government work, the general program of drug and vaccine development in the biodefense world and at BARDA, and career opportunities for scientists in government.

TWiV #119 - Science and journalism with David Tuller

twiv@twiv.tv (Vincent Racaniello) — Sun, 06 Feb 2011 18:32:56 +0000

Vincent and journalist David Tuller converse about the state of science reporting by the press.

TWiV #118 - The virus always rings twice

twiv@twiv.tv (Vincent Racaniello) — Sun, 30 Jan 2011 17:28:44 +0000

Vincent, Alan, and Rich answer listener questions about vaccinia virus, fungal viruses, synthetic viruses, influenza vaccine, HeLa cells, multiplicity of infection, and much more.

TWiV #117 - The Panic Virus with Seth Mnookin

twiv@twiv.tv (Vincent Racaniello) — Sun, 23 Jan 2011 18:07:00 +0000

Vincent and Rich converse with Seth Mnookin, author of The Panic Virus, about vaccines, autism, thimerosal, and a contagion of human unreason run wild.

TWiV #116 - Cocaine, colonies, and chickens

twiv@twiv.tv (Vincent Racaniello) — Sun, 16 Jan 2011 19:26:00 +0000

Vincent, Dickson, Alan, and Rich review an adenovirus-based vaccine strategy against drug addiction, a field trial of RNAi to prevent Israeli acute paralysis virus infection in honeybees, and suppression of avian influenza transmission in transgenic chickens.

TWiV #115 - Color me infected

twiv@twiv.tv (Vincent Racaniello) — Sun, 09 Jan 2011 21:38:00 +0000

Vincent, Alan, Rich and Marc discuss the finding that a limited number of incoming herpesviral genomes can replicate and express in a cell, and controlling viral replication inAedes aegypti with a Wolbachia symbiont.

derek_smith.mp4

twiv@twiv.tv (Vincent Racaniello) — Tue, 04 Jan 2011 16:04:00 +0000

TWiV #114 - Ten out of '10

twiv@twiv.tv (Vincent Racaniello) — Sun, 02 Jan 2011 17:26:00 +0000

Vincent, Alan, and Rich revisit ten compelling virology stories of 2010.

TWiV #113 - Alan Rein on XMRV

twiv@twiv.tv (Vincent Racaniello) — Sun, 26 Dec 2010 21:26:00 +0000

Vincent, Alan, and Rich discuss the retrovirus XMRV with retrovirologist Alan Rein of the National Cancer Institute.

rich_reminisces_720p.mov

twiv@twiv.tv (Vincent Racaniello) — Thu, 23 Dec 2010 20:34:00 +0000

TWiV #112 - Creating a killer poxvirus

twiv@twiv.tv (Vincent Racaniello) — Sun, 19 Dec 2010 18:25:00 +0000

Vincent, Alan, and Rich review the making of a virulent poxvirus by insertion of the gene encoding IL-4, and severe 2009 H1N1 influenza due to pathogenic immune complexes.

twiv111.mp4

twiv@twiv.tv (Vincent Racaniello) — Tue, 14 Dec 2010 12:19:00 +0000

twiv111.wmv

twiv@twiv.tv (Vincent Racaniello) — Tue, 14 Dec 2010 03:02:11 +0000

twiv111.flv

twiv@twiv.tv (Vincent Racaniello) — Mon, 13 Dec 2010 19:00:00 +0000

TWiV #111 - Live at Florida Gulf Coast University

twiv@twiv.tv (Vincent Racaniello) — Mon, 13 Dec 2010 02:58:00 +0000

The TWiV crew meets with members of the Florida Keys Mosquito Control District at Florida Gulf Coast University to discuss dengue in Florida and how to control it.

TWiV #110 - CSI virology

twiv@twiv.tv (Vincent Racaniello) — Sun, 05 Dec 2010 12:48:00 +0000

Vincent, Alan, Rich, and Dickson discuss bacteria that can utilize arsenic in place of phosphorus, the passing of Frank Fenner, polio outbreak in The Congo, solving criminal cases of HIV transmission, and classifying viruses by capsid structure.

TWiV #109 - Virologia en México

twiv@twiv.tv (Vincent Racaniello) — Mon, 29 Nov 2010 03:41:00 +0000

Vincent visits Mexico City and speaks with Rosa Maria del Angel and Ana Lorena Gutiérrez about virology in Mexico, and their work on dengue and caliciviruses.

TWiV #108 - Barking up the right Tre

twiv@twiv.tv (Vincent Racaniello) — Sun, 21 Nov 2010 21:40:00 +0000

Vincent, Alan, Rich, and Saul review the evolution of HIV-1 specific recombinases, and down-regulation of a host microRNA by a viral noncoding RNA.

TWiV #107 - Warning - this virus contains email

twiv@twiv.tv (Vincent Racaniello) — Mon, 15 Nov 2010 02:21:00 +0000

Vincent, Dickson, Alan, and Rich answer listener questions about poliovirus, social media, dengue, influenza, evolution, gel filtration, and much more.

TWiV #106 - Making viral DNA II

twiv@twiv.tv (Vincent Racaniello) — Sat, 06 Nov 2010 21:08:00 +0000

Vincent, Dickson, and Rich continue Virology 101 with a second installment of their discussion of how viruses with DNA genomes replicate their genetic information.

TWiV106.wmv

twiv@twiv.tv (Vincent Racaniello) — Fri, 05 Nov 2010 18:04:58 +0000

TWiV106.flv

twiv@twiv.tv (Vincent Racaniello) — Wed, 03 Nov 2010 21:03:00 +0000

TWiV #105 - Finches score again

twiv@twiv.tv (Vincent Racaniello) — Sun, 31 Oct 2010 17:45:00 +0000

Vincent, Dickson, Alan, and Rich review eradication of rinderpest, endogenous hepatitis B virus in the zebra finch genome, and identification of the cell receptor for an extinct retrovirus.

TWiV #104 - The colony-collapse blues

twiv@twiv.tv (Vincent Racaniello) — Mon, 25 Oct 2010 01:10:00 +0000

The entire TWiV family reviews the latest ideas about colony collapse disorder of honeybees, and resurgence of monkeypox in Africa.

TWiV #103 - Shots with LJ Tan

twiv@twiv.tv (Vincent Racaniello) — Sun, 17 Oct 2010 19:00:00 +0000

Vincent and Alan discuss influenza vaccines with LJ Tan of the American Medical Association.

sfb455_640x480.mp4

twiv@twiv.tv (Vincent Racaniello) — Wed, 13 Oct 2010 02:37:52 +0000

TWiV102.mov

twiv@twiv.tv (Vincent Racaniello) — Tue, 12 Oct 2010 16:28:10 +0000

TWiV #102 - Catch me if you can in Munich

twiv@twiv.tv (Vincent Racaniello) — Mon, 11 Oct 2010 14:33:00 +0000

A conversation about the RNA sensor RIG-I, adenovirus gene therapy, a universal influenza vaccine, and rabies virus, recorded in Munich, Germany at the SFB455 symposium ‘Viral offense and immune defense’.

TWiV #101 - Sizing up adenovirus

twiv@twiv.tv (Vincent Racaniello) — Sun, 03 Oct 2010 20:44:00 +0000

Vincent, Alan, Rich, Dickson, and Hamish review the three-dimensional structure of adenovirus, and the role of adenovirus type 36 in obesity.

TWiV #100 - TWiV catches a big fish

twiv@twiv.tv (Vincent Racaniello) — Sun, 26 Sep 2010 19:19:00 +0000

Vincent, Alan, and Rich celebrate the 100th episode of TWiV by talking about viruses with Nobel Laureate David Baltimore.

TWiV #99 - ICAAC Boston 2010

twiv@twiv.tv (Vincent Racaniello) — Mon, 20 Sep 2010 00:53:00 +0000

On episode #99 of the podcast This Week in Virology, Vincent tours the 50th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), speaking with exhibitors and visitors, including Professors Derek Smith, Michael Schmidt, Frederick Hayden, and Myra McClure.

Host links Vincent Racaniello

Links for this episode:

50th ICAAC
ICAAC daily press conference videos (including Prof. Myra McClure)
Antigenic cartography
Antimicrobial properties of copper