PowerPoint Tutorials and Blog

VisiNets

2015-07-07T13:03:00.001-04:00

With Visinets Inc. we have developed a novel tool for graphical modeling of signaling pathways, Visinets. This tool allows for both modeling and visualization of biological networks in a user-friendly format. The Visinets mathematical approach is based on causal mapping (CMAP) with simplified ODEs that have been fully integrated with graphical interface. It offers more competent analysis of pathway dynamics than VisiPaths.

For more details refer to our recent publication: Spychala J, Spychala P, Gomez S, Weinreb GE. Visinets: A Web-Based Pathway Modeling and Dynamic Visualization Tool. Yoon B-J, ed. PLoS ONE. 2015;10(5):e0123773. doi:10.1371/journal.pone.0123773.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4447416/

VisiPaths - Updated Signaling Pathways Visualizer and Simulator

2012-02-26T11:07:00.002-05:00

We'd like to announce an update to our rule-based pathways visualization tool which allows you to follow signaling pathways as they propagate through the cellular networks.

Unlike other tools, we've built VisiPaths to be fully interactive so that the user can alter any node property and visualize the changes it causes to signaling outcomes. The user can also set any node action in a time-like fashion, using complex constructs such as adding a delay function for a specific connection.

And we've worked hard to build a complex and powerful toolset that allows you to separately configure and set early signaling events (such as protein phosphorylation/acetylation, etc) and late (transcription) signaling events . And once you configure a pathway, the VisiPaths app will do the hard work of automatically visualizing its oscillations.

To sum up, the main benefits of VisiPaths are three fold:

VisiPaths can map a complex array of connections (interactions) that account for a great number of interacting scenarios
VisiPaths supports nodes with unknown kinetic characteristics (inferred indirectly from cell and animal studies).
VisiPaths provides a powerful interactive graphical platform to assemble pathway maps in an intuitive way. And to help users get started, VisiPaths includes several pre-assembled pathways which could be further altered by the user.

We invite you to check out the app at VisiPaths.com

VisiPaths - Signaling Pathways Visualizer and Simulator

2011-02-09T22:43:00.005-05:00

As a special Valentines day present to all our users we'd like to introduce the beta of VisiPaths.com!

VisiPaths allows users to visualize cellular signaling pathways as they propagate through the network. The app allows the user to track

signal transduction
signal crosstalk
pathways interactions
other systems biology modeling
and more!

Once a pathway is loaded and setup, the user can also alter any node properties, including activity and connections, and visualize the changes it causes to the signaling pathways - all in realtime.

With the ease of using a standards compliant web-app, you can modify any parts of the pathway including adding new nodes and creating new connections/interactions to test how they would affect overall signaling pathways.

All node actions can be based on a timer using delay function for each connection. This allows to see separately early (protein phosphorylation) and late (transcription) signaling events and also allows to visualize oscillations.

The app is available as a limited beta to the general public. We invite you to visit VisiPaths.com and signup for an account now.

ScienceSlides Online Improvements

2011-01-03T18:29:00.000-05:00

With the new year we are extremely happy to announce a few ScienceSlides Online improvements that we just launched this afternoon.

Faster and better search. With the new change you will be able to search though titles and tags of the slides, but also the reference synopsis. We hope that with this addition you'll find it easier to find the slides that you are looking for.
Performance improvements. Faster load times - no more waiting!
FREE Wednesday Slide download is back online with a little twist. Now we'll ask you to "pay with a tweet" before downloading to spread the word about ScienceSlides content.
Various backbend changes to support our new VisiPaths product which we are releasing very soon. We're very excited about 2011 and can't wait to show you what we have been working on.

Stay tuned.

ScienceSlides 2010 - 13th Edition

2010-05-31T16:03:00.005-04:00

We are happy to extend out commitment to the scientific community by announcing our updated suite of products with ScienceSlides 2010.

For this latest release, our content has been further expanded and updated. Many fields have been revised, including mTOR protein, Ion Channel physiology, Calcium Homeostasis, Cytoskeleton, mRNA processing, Growth Factor, Tumor Suppressor and Oncogene signaling, TLR and Fcgamma signaling. Significant expansion has been made in Molecular Pharmacology and Medicinal Chemistry.

As always all slides are available in PowerPoint (PPT) format which is compatible across all major operating systems and presentation tools.

Visit out store for pricing and delivery options.

October Molecular Cell Cover Design

2009-10-28T09:25:00.015-04:00

We're pleased to announce that our cover design was picked for the October issue of Molecular Cell magazine.

The cover features 3′ end processing of replication-dependent histone pre-mRNA. Histone pre-mRNA (top wire) is cleaved 5 nucleotides after the stem loop by CPSF-73, represented by the wire cutter.

We've worked closely with the editors and the scientists who are featured in the article to create a design that best illustrates the discovery. Using the flashlight in the cover is descriptive of the discovery as well as a nice play on words to the title "FLASH Illuminates Histone Pre-mRNA 3' End Clevage."

Apart from creating ScienceSlides Online and ScienceSlides on CD, we also specialize in custom scientific illustrations. Please email us for more info. We're experts on designing graphics for PowerPoint as well as 3D modeling tools such as 3d Studio Max.

For more PPT slides check out our large online collection available for easy download.

pre-mRNA Slides
histones Slides
CPSF Slides
and more ...

You should also follow us on twitter to get weekly free slide downloads.

ScienceSlides 2009 Fall Edition

2009-10-15T12:55:00.006-04:00

Announcing ScienceSlides 2009 Fall Edition. Available on CD as an easy-to-use PowerPoint plugin for OSX and Windows. Includes thousands of high quality Signaling Pathways slides. All slides are ready-to-use and fully modifiable. Some of the new content for this release includes:

We keep the content on ScienceSlides Online current so expect regular updates on this blog outlining future content additions. Also, if you would like to see any particular topic and subject covered, please don't hesitate to email us at contact+blog@visiscience.com or fill out our survey.

You should also follow us on twitter to get weekly free slide downloads.

Mutant B-RAF and RAF1 regulation

2009-09-11T07:31:00.009-04:00

Mutant B-RAF is found in a variety of cancers. We designed a couple high-quality ready-to-use PowerPoint slides to help show this relationship for presentations and illustrations.

We keep the content on ScienceSlides current so expect to see more regular updates on this blog outlining some of the content additions. Also, if you would like to see any particular topic and subject covered, please don't hesitate to email us at contact+blog@visiscience.com or fill out our survey.

Signaling Pathways PPT Toolkits and Templates

2009-08-06T07:44:00.006-04:00

We've updated our library again, this time with a few PPT toolkit slides that are designed to be used as building blocks for your own custom presentations.

For example, newly up-loaded slides: Scaffolding proteins in MAPK pathway and Receptor Toolkit

As with any PPT slide from ScieceSlides, you have the capability to change colors, sizes and text labels of all the graphical assets.

More professionally designed PPT slide templates available at ScienceSlides.com

Src Kinase Signaling Pathways Slides

2009-07-30T09:47:00.007-04:00

As part of our monthly Signaling Pathways updates we added a number of PPT slides this week. Here are some of the additions:

We strive to keep the content on ScienceSlides current so expect to see regular updates on this blog outlining some of the content additions. Also, if you would like to see any particular topic and subject covered, please don't hesitate to email us at contact+blog@visiscience.com.

More updates coming in later blog posts!

Signaling Pathways Powerpoint Slides

2009-06-30T09:57:00.009-04:00

Our slide catalog contains a large library of Signaling Pathways, Cell Signaling and Cell Transduction Powerpoint Slides. And to illustrate, we've decided to outline a subset of our content with a short description, here on our blog.

Below is a listing of some of our slides:

Ras regulators

Ras oncogene is regulated by GTP binding and GTP hydrolysis, which is associated with Ras-dependent signal transduction. Several factors affect Ras GTP binding and hydrolysis, including T-cell receptors, GPCR receptors, Growth factors and calcium.

Rb acetylation in DNA damage response

Retinoblastoma protein is acetylated by p300 protein acetylase and deacetylated by HDAC and SIRT1. Acetylation causes Rb activation and E2F sequestration and deacetylation reverses this process.

Stepwise EGFR-HER2 activation and phosphorylation

EGFR-HER2 receptor complex is an important trigger of the oncogenic process. The process of tyrosine phosphorylation upon receptor activation undergoes a sequence of molecular steps that ultimately lead to signal transduction in cancer.

Rb pro-apoptotic and anti-apoptotic function upon DNA damage

Retinoblastoma protein can have both pro- and anti-apoptotic functions in DNA damage response, depending on the particular cell type and activation state.

Major types of stem cells

Stem cells have been increasingly viewed as potential therapeutic modalities in several diseases. In this respect both embrional and adult stem cells showed therapeutic potential.

Rb regulation in cell cycle

Retinoblastoma protein is an important regulator of cell cycle. Its association with E2F transcription factor is regulated by Rb phosphorylation throughout of the cycle by several protein kinases, including cdk4, cdk6, cdk2 and protein phosphatases, including PP2A and PP1.

Mechanisms of Vaccinia A36R in F-actin nucleation

Vaccinia A36R protein interacts with N-Wasp protein through Nck and Grb2 proteins. This interaction activates Arp2/Arp3 complex and F-actin nucleation.

PTEN phosphorylation I

PTEN phosphorylation regulates protein stability and activity through altering PTEN subcellular localization and conformation.

p53 posttranslational modifications - an overview

p53 tumor suppressor protein is under complex regulation through protein phosphorylation, acetylation, ubiquitination, neddylation, sumoylation and methylation. These modification affect both protein activity and stability.

Regulation of IP3R calcium channel

IP3R calcium channel is regulated by several signaling pathways, including T-cell receptor, GPCR receptors, etc. These signaling pathways converge on cAMP and PKA, G proteins beta and gamma, CDK1, BCL-2, BCL-xL IRBIT, PKG/IRAG and other signaling proteins.

And much more, of course. As always, you can browse and download all our Signaling Pathways slides on ScienceSlides Online or purchase the ScienceSlides Suite on CD for your OS X or Windows Desktop.

New Slides on ScienceSlides Online

2009-06-20T12:29:00.010-04:00

As part of our monthly update of PowerPoint Slides on ScienceSlides Online we uploaded a number of slides this week. Here are some examples of the additions:

And much more. Again, we strive to keep the content on ScienceSlides current so expect to see regular updates on this blog outlining some of the content additions. Also, if you would like to see any particular topic and subject covered, please don't hesitate to email us at contact+blog@visiscience.com.

Visiscience at Google IO

2009-05-28T14:47:00.006-04:00

We're excited to start using all the new web technology that was announced at Google IO. Specifically, our goal is to make it easier for Scientists and Educators to share information, create presentations and use our PowerPoint Science Slides.

Apart from regularly updating our slides with new Signaling Pathway, Molecular Pathology, Biochemistry and Pharmacology Slides we're also looking forward to the release new products in the near future. Products that will ease the time required in preparing data-sets into presentations.

We'll keep you posted on everything here.

ScienceSlides Online - The new way to get our popular slides!

2009-04-02T21:38:00.009-04:00

Visiscience has launched a new way of purchasing slides for students - ScienceSlides Online. In contrast to traditional ScienceSlides Suite, Standard or Molecular Pathology, which is sold on CD as a stand alone Win or OS X application, ScienceSlides Online gives scientists quick access to full content (of over 4800 slides and objects.)

ScienceSlides Online contains the following categories of PowerPoint (PPT) slides:

In principle, students can preview all slides in our database, select the one they are interested in, and download toward the credits they have purchased. For example, if a user has bought 40 credits, he/she may download one or more slides (one at the time, up to 10) within one year or until all credits are used, whichever comes first.

Students, who do not want to pay the full price of the Suite, may have the slides they want at the fraction of price. Initial response from our customers is very positive and we hope this new offer will allow more students to access our large and continually updated database of slides.

Jozef Spychala, PhD
Visiscience Inc.
Chapel Hill, NC, USA

ScienceSlides 2009 – The 11th Edition

2009-03-30T21:54:00.000-04:00

Despite the challenging environment in the marketplace, Visiscience has been successful with the release of the 11th edition! Our customer base has continued to increase. The response from users have been very positive and, as a result, new ScienceSlides version incorporates many suggestions from our customers.

We are especially grateful to our users who pointed out few errors found in our slides and we are making extra effort to avoid them in the future. The content has been further expanded and updated. Many fields have been revised, including Ion Channel physiology, Calcium Homeostasis, Cytoskeleton, mRNA processing, Growth Factor, Tumor Suppressor and Oncogene signaling, TLR and Fcgamma signaling. Significant expansion has been made in Molecular Pharmacology and Medicinal Chemistry.

As always all slides are available in PowerPoint (PPT) format which is compatible across all major operating systems and presentation tools.

ScienceSlides Seminar on the NIH Campus

2006-09-08T22:17:00.000-04:00

For scientists interested in improving their scientific presentations we invite to a ScienceSlides course, including ScienceSlides 2006 Fall Edition preview and tips on PowerPoint for scientists, on the NIH campus!

Course: 915 -06S, September 18, time: 10:30 - 11:30
Location: Building 12A, Room B51
Speaker: Jozef Spychala, Ph.D.
Course details: Go to NIH Course listings website

All scientists in Bethesda, Rockville and Washington, DC area are invited!

Visiscience Team