Science News http://sciencenewsguide.info Sat, 05 Dec 2009 20:20:17 +0000 http://wordpress.org/?v=2.8.4 en hourly 1 ScienceNewshttp://feedburner.google.com The Ubiquity of Exaptation http://sciencenewsguide.info/2009/12/05/the-ubiquity-of-exaptation/ http://sciencenewsguide.info/2009/12/05/the-ubiquity-of-exaptation/#comments Sat, 05 Dec 2009 20:20:17 +0000 Pharyngula http://scienceblogs.com/pharyngula/2009/12/the_ubiquity_of_exaptation.php On Thursday, I gave a talk at the University of Minnesota at the request of the CASH group on a rather broad subject: evolution and development of the nervous system. That's a rather big umbrella, and I had to narrow it down a lot. I say, a lot. The details of this subject are voluminous and complex, and this was a lecture to a general audience, so I couldn't even assume a basic science background. So I had to think a bit.

I started the process of working up this talk by asking a basic question: how did something as complex as the nervous system form? That's actually not a difficult problem — evolution excels at generating complexity — but I knew from experience that the first hurdle to overcome would be a common assumption, the idea that it was all the product of

purposeful processes, ranging from adaptationist compulsion to god's own intent — that drive organisms to produce smarter creatures. I decided that what I wanted to make clear is that the origin of many fundamental traits of the nervous system is by way of chance and historical constraints, that the primitive utility of some of the things we take for granted in the physiology of the brain does not lie in anything even close to cognition. The roots of the nervous system are in surprisingly rocky ground for brains, and selection's role has been to sculpt the gnarly, weird branches of chance into a graceful and useful shape.

So I put together a talk called The Ubiquity of Exaptation (2.7M pdf). The barebones presentation itself might not be very informative, I'm afraid, since it's a lot of pictures and diagrams, so I'll try to give a brief summary of the argument here.

The subtitle of the talk is "Nothing evolved for a purpose", and I mean that most seriously. Evolved innovations find utility in promoting survival, and can be honed by selection, but they aren't put there in the organism for a purpose. The rule in evolution is exaptation, the cooption of elements for use in new properties, with a following shift in function. It's difficult to just explain, so I picked three examples from the evolution of the nervous system that I hoped would clarify the point. The three were 1) the electrical properties of the cell membrane, which are really a byproduct of mechanisms of maintaining salt balance; 2) synaptic signaling, which coopts cellular machinery that evolved for secretion and detecting external signals; and 3) pathfinding by neurons, the process that generates patterned connectivity between cells, and which uses the same mechanisms of cellular motility that we find in free-living single celled organisms.

  1. Excitability. This was the toughest of the three to explain, because I wasn't talking to an audience of biophysicists. Our neurons (actually, all of our cells; even egg cells have interesting electrical properties) maintain an electrical potential, a voltage, across their membranes that you can measure with very tiny electrodes. This voltage undergoes short, sharp transient changes that produce action potentials, waves of current that move down the length of the cell. How do they do that? Where did this amazing electrical trick come from?

    The explanation lies in a common problem. Our cells have membranes that are permeable to water, and they also must contain a collection of proteins that are not present in the external environment. The presence of these functional solutes inside the cell should create an osmotic gradient, so that water would flow in constantly, trying to dilute the interior to be iso-osmotic (the same concentration) as the outside. Some cells have different ways to cope: one way is to build cell walls that retain the concentration in the interior with pressure; another is to have specialized organelles to constantly pump out water. Our cells use a clever and rather lazy scheme: they compensate for the high internal concentration of essential proteins by creating a high external concentration of some other substance, which is impermeant to the cell membrane. Water has the same concentration inside and outside, but there are different distributions of solutes inside and outside.

    What we use to generate these differential distributions are ionic salts, charged molecules. Positively charged sodium ions are high in concentration outside, while positively charged potassium ions and negatively (on average) charged proteins are high in concentration on the inside. Because these are charged ions, their distribution also coincidentally sets up a voltage difference. I confess, I did show the audience the Goldman equation, which is a little scary, but I reassured them that they didn't have to calculate it — they just needed to understand that the arrangements of salts in cells and the extracellular space generates a voltage that is simply derived from the physical and chemical properties of the situation.

    We use variations in these voltages to send electrical signals down the length of our nerves, but they initially evolved as a mechanism to cope with maintaining our salt balance. We're also used to thinking of these electrical abilities as being part of a complicated nervous apparatus, but initially, they found utility in single-celled organisms. As an example, I described the behavior of paramecia. The paramecium swims about by beating cilia, like little oars; the membrane of the paramecium maintains an electrical potential, and also contains selectively permeable ion channels that can be switched open or closed. When the organism bumps into an obstacle, the channels open, calcium rushes in as the potential changes, and the cilia all reverse the direction of their beating, making the paramecium tumble backwards. The electrical properties of your brain are also functionally useful to single-celled organisms.

    I concluded this section by trying to reassure everyone that their brain is something more than just a collection of paramecia swimming about. Although the general properties of the membrane are the same, evolution has also refined and expanded the capabilities of the neuronal membrane: there are many different kinds of ion channels, which we can see by their homology to one another are also products of evolution, and each one is specialized in unique ways to add flexibility to the behavioral repertoire of the cell. The origins of the electrical properties are a byproduct of salt homeostasis, but once that little bit of function is available, selection can amplify and hone the response of the system to get some remarkably sophisticated results.

  2. Synaptic signaling. Shuttling electrical signals across the membrane of a cell is one thing, but a nervous system is another: that requires that multiple cells send signals to one another. A wave of current flowing through a membrane in one cell needs to be transmitted to an adjacent cell, and the way we do that is through specialized connections called synapses. A chemical synapse is a specialized junction between two cells: on one side, the presynaptic side, a change in membrane voltage triggers the release of chemicals into the extracellular space; on the recieving side, the post-synaptic side, there are localized collections of receptors for that chemical signal, and when they bind the chemical (called a neurotransmitter), they cause changes in the membrane voltage on their side.

    Once again, the cell simply reuses machinery that evolved for other purposes to carry out these functions. Cells use a secretory apparatus all over the place; we package up hormones or enzymes or other chemicals into small balloons of membrane called vesicles, and we can export them to the outside of the cell by simply fusing the vesicle with the cell membrane. Lots our cells do this, not just neurons, and it's also a common function in single celled organisms. Brewer's yeast, for instance, contain significant pieces of the membrane-associated signaling complex, or MASC, althogh they of course don't make true synapses, which requires two cells working together in a complementary fashion.

    I described the situation in Trichoplax, an extremely simple multicellular organism which only has four cell types. The Trichoplax genome has been sequenced, and found to contain a surprising number of the proteins used in synaptic signaling…but it doesn't have a brain or any kind of nervous system, and none of its four cell types are neurons. What a mindless slug like Trichoplax uses these proteins for is secretion: it makes digestive enzymes, not neurotransmitters, and sprays them out onto the substrate to dissolve its food. Again, in more derived organisms with nervous systems, they have simply coopted this machinery to use in signaling between neurons.

    As usual, I had to make sure that nobody came away from this thinking their brain was a conglomeration of Trichoplax squirting digestive enzymes around. Yeast, choanoflagellates, and sponges have very primitive precursors to the synapse; we can look at the evolutionary history of the structure and see extensive refinement and elaboration. The modern vertebrate synapse is built from over 1500 different proteins — it's grown and grown and grown from its simpler beginnings.

  3. Pathfinding. How do we make circuits of neurons? I've just explained how we can conduct electrical signals down single cells, and how pairs of cells can communicate with each other, but we also need to be able to connect up neurons in reliable and useful ways, making complex patterned arrangements of cells in the brain. We actually know a fair amount about how neurons in the developing nervous system do that.

    Young nerve cells form a structure called the growth cone, an amoeboid process that contains growing pieces of the cell skeleton (fibers made of proteins like tubulin and actin), enzymes that act as motor proteins, cytoplasm, and membrane. These structures move: veils of membrane called lamellopodia flutter about, antennae-like rods called filopodia extend and probe the environment, and the whole bloblike mass expands in particular directions by the bulk flow of cytoplasm. The cell body stays in place, usually, and it sends out this little engine of movement that trundles away, leaving an axon behind it.

    "Amoeboid" is the magic word. The growth cone uses the same cellular machinery single-celled organisms use for movement on a substrate. Once again, exaptation strikes, and the processes that amoebae use to move and find microorganismal prey are the same ones that the cells in your brain used to lay down pathways of circuitry in your brain.

    Furthermore, there is no grand blueprint of the brain anywhere in the system. Growing neurons are best thought of as simple cellular automata which contain a fairly simple set of rules that lead them to follow entirely local cues to a final destination. I described some of the work that David Bentley did years ago (and also some of my old grasshopper work) that showed that not only can the cues be identified in the environment, but that experimental ablation of those intermediate targets can produce cells that are very confused and make erroneous navigational decisions.

    We also contain a great many possible signals: long- and short-range cues, signals that attract or repel, and also signals that can change gene expression inside the neuron and change its behavior in even more complicated ways. It's still at its core an elaboration of behaviors found in protists and even bacteria; we are looking at amazingly powerful emergent behaviors that arise from simple mechanisms.

And that was the story. Properties of the nervous system that are key to its function and that many of us naively regard as unique to neurons are actually expanded, elaborated, specialized versions of properties that are also present in organisms that lack brains, nervous systems, or even neurons…and that aren't even multicellular. This is precisely what we'd expect from evolutionary origins, that everything would have its source in simpler precursors. Furthermore, it's a mistake to try and shoehorn those precursors into necessarily filling the same functions as their descendants today. Cooption is the rule. Even the brains of which we are so proud are byblows of more fundamental functions, like homeostasis, feeding, and locomotion.

Read the comments on this post... Related posts:
  1. Irwin Neher: Chemistry helps neuroscience: the use of caged compounds and indicator dyes for the study of neurotransmitter release Ah, a solid science talk. It wasn't bad, except that...
  2. Now hear this Deep in the ear, 95 percent of the cells that...
  3. Protecting cells from their neighbors Almost all organisms evolve from a single cell, a fertilised...
]]>

On Thursday, I gave a talk at the University of Minnesota at the request of the CASH group on a rather broad subject: evolution and development of the nervous system. That’s a rather big umbrella, and I had to narrow it down a lot. I say, a lot. The details of this subject are voluminous and complex, and this was a lecture to a general audience, so I couldn’t even assume a basic science background. So I had to think a bit.

I started the process of working up this talk by asking a basic question: how did something as complex as the nervous system form? That’s actually not a difficult problem — evolution excels at generating complexity — but I knew from experience that the first hurdle to overcome would be a common assumption, the idea that it was all the product of

purposeful processes, ranging from adaptationist compulsion to god’s own intent — that drive organisms to produce smarter creatures. I decided that what I wanted to make clear is that the origin of many fundamental traits of the nervous system is by way of chance and historical constraints, that the primitive utility of some of the things we take for granted in the physiology of the brain does not lie in anything even close to cognition. The roots of the nervous system are in surprisingly rocky ground for brains, and selection’s role has been to sculpt the gnarly, weird branches of chance into a graceful and useful shape.

So I put together a talk called The Ubiquity of Exaptation (2.7M pdf). The barebones presentation itself might not be very informative, I’m afraid, since it’s a lot of pictures and diagrams, so I’ll try to give a brief summary of the argument here.

The subtitle of the talk is “Nothing evolved for a purpose”, and I mean that most seriously. Evolved innovations find utility in promoting survival, and can be honed by selection, but they aren’t put there in the organism for a purpose. The rule in evolution is exaptation, the cooption of elements for use in new properties, with a following shift in function. It’s difficult to just explain, so I picked three examples from the evolution of the nervous system that I hoped would clarify the point. The three were 1) the electrical properties of the cell membrane, which are really a byproduct of mechanisms of maintaining salt balance; 2) synaptic signaling, which coopts cellular machinery that evolved for secretion and detecting external signals; and 3) pathfinding by neurons, the process that generates patterned connectivity between cells, and which uses the same mechanisms of cellular motility that we find in free-living single celled organisms.

  1. Excitability. This was the toughest of the three to explain, because I wasn’t talking to an audience of biophysicists. Our neurons (actually, all of our cells; even egg cells have interesting electrical properties) maintain an electrical potential, a voltage, across their membranes that you can measure with very tiny electrodes. This voltage undergoes short, sharp transient changes that produce action potentials, waves of current that move down the length of the cell. How do they do that? Where did this amazing electrical trick come from?

    The explanation lies in a common problem. Our cells have membranes that are permeable to water, and they also must contain a collection of proteins that are not present in the external environment. The presence of these functional solutes inside the cell should create an osmotic gradient, so that water would flow in constantly, trying to dilute the interior to be iso-osmotic (the same concentration) as the outside. Some cells have different ways to cope: one way is to build cell walls that retain the concentration in the interior with pressure; another is to have specialized organelles to constantly pump out water. Our cells use a clever and rather lazy scheme: they compensate for the high internal concentration of essential proteins by creating a high external concentration of some other substance, which is impermeant to the cell membrane. Water has the same concentration inside and outside, but there are different distributions of solutes inside and outside.

    What we use to generate these differential distributions are ionic salts, charged molecules. Positively charged sodium ions are high in concentration outside, while positively charged potassium ions and negatively (on average) charged proteins are high in concentration on the inside. Because these are charged ions, their distribution also coincidentally sets up a voltage difference. I confess, I did show the audience the Goldman equation, which is a little scary, but I reassured them that they didn’t have to calculate it — they just needed to understand that the arrangements of salts in cells and the extracellular space generates a voltage that is simply derived from the physical and chemical properties of the situation.

    We use variations in these voltages to send electrical signals down the length of our nerves, but they initially evolved as a mechanism to cope with maintaining our salt balance. We’re also used to thinking of these electrical abilities as being part of a complicated nervous apparatus, but initially, they found utility in single-celled organisms. As an example, I described the behavior of paramecia. The paramecium swims about by beating cilia, like little oars; the membrane of the paramecium maintains an electrical potential, and also contains selectively permeable ion channels that can be switched open or closed. When the organism bumps into an obstacle, the channels open, calcium rushes in as the potential changes, and the cilia all reverse the direction of their beating, making the paramecium tumble backwards. The electrical properties of your brain are also functionally useful to single-celled organisms.

    I concluded this section by trying to reassure everyone that their brain is something more than just a collection of paramecia swimming about. Although the general properties of the membrane are the same, evolution has also refined and expanded the capabilities of the neuronal membrane: there are many different kinds of ion channels, which we can see by their homology to one another are also products of evolution, and each one is specialized in unique ways to add flexibility to the behavioral repertoire of the cell. The origins of the electrical properties are a byproduct of salt homeostasis, but once that little bit of function is available, selection can amplify and hone the response of the system to get some remarkably sophisticated results.

  2. Synaptic signaling. Shuttling electrical signals across the membrane of a cell is one thing, but a nervous system is another: that requires that multiple cells send signals to one another. A wave of current flowing through a membrane in one cell needs to be transmitted to an adjacent cell, and the way we do that is through specialized connections called synapses. A chemical synapse is a specialized junction between two cells: on one side, the presynaptic side, a change in membrane voltage triggers the release of chemicals into the extracellular space; on the recieving side, the post-synaptic side, there are localized collections of receptors for that chemical signal, and when they bind the chemical (called a neurotransmitter), they cause changes in the membrane voltage on their side.

    Once again, the cell simply reuses machinery that evolved for other purposes to carry out these functions. Cells use a secretory apparatus all over the place; we package up hormones or enzymes or other chemicals into small balloons of membrane called vesicles, and we can export them to the outside of the cell by simply fusing the vesicle with the cell membrane. Lots our cells do this, not just neurons, and it’s also a common function in single celled organisms. Brewer’s yeast, for instance, contain significant pieces of the membrane-associated signaling complex, or MASC, althogh they of course don’t make true synapses, which requires two cells working together in a complementary fashion.

    I described the situation in Trichoplax, an extremely simple multicellular organism which only has four cell types. The Trichoplax genome has been sequenced, and found to contain a surprising number of the proteins used in synaptic signaling…but it doesn’t have a brain or any kind of nervous system, and none of its four cell types are neurons. What a mindless slug like Trichoplax uses these proteins for is secretion: it makes digestive enzymes, not neurotransmitters, and sprays them out onto the substrate to dissolve its food. Again, in more derived organisms with nervous systems, they have simply coopted this machinery to use in signaling between neurons.

    As usual, I had to make sure that nobody came away from this thinking their brain was a conglomeration of Trichoplax squirting digestive enzymes around. Yeast, choanoflagellates, and sponges have very primitive precursors to the synapse; we can look at the evolutionary history of the structure and see extensive refinement and elaboration. The modern vertebrate synapse is built from over 1500 different proteins — it’s grown and grown and grown from its simpler beginnings.

  3. Pathfinding. How do we make circuits of neurons? I’ve just explained how we can conduct electrical signals down single cells, and how pairs of cells can communicate with each other, but we also need to be able to connect up neurons in reliable and useful ways, making complex patterned arrangements of cells in the brain. We actually know a fair amount about how neurons in the developing nervous system do that.

    Young nerve cells form a structure called the growth cone, an amoeboid process that contains growing pieces of the cell skeleton (fibers made of proteins like tubulin and actin), enzymes that act as motor proteins, cytoplasm, and membrane. These structures move: veils of membrane called lamellopodia flutter about, antennae-like rods called filopodia extend and probe the environment, and the whole bloblike mass expands in particular directions by the bulk flow of cytoplasm. The cell body stays in place, usually, and it sends out this little engine of movement that trundles away, leaving an axon behind it.

    “Amoeboid” is the magic word. The growth cone uses the same cellular machinery single-celled organisms use for movement on a substrate. Once again, exaptation strikes, and the processes that amoebae use to move and find microorganismal prey are the same ones that the cells in your brain used to lay down pathways of circuitry in your brain.

    Furthermore, there is no grand blueprint of the brain anywhere in the system. Growing neurons are best thought of as simple cellular automata which contain a fairly simple set of rules that lead them to follow entirely local cues to a final destination. I described some of the work that David Bentley did years ago (and also some of my old grasshopper work) that showed that not only can the cues be identified in the environment, but that experimental ablation of those intermediate targets can produce cells that are very confused and make erroneous navigational decisions.

    We also contain a great many possible signals: long- and short-range cues, signals that attract or repel, and also signals that can change gene expression inside the neuron and change its behavior in even more complicated ways. It’s still at its core an elaboration of behaviors found in protists and even bacteria; we are looking at amazingly powerful emergent behaviors that arise from simple mechanisms.

And that was the story. Properties of the nervous system that are key to its function and that many of us naively regard as unique to neurons are actually expanded, elaborated, specialized versions of properties that are also present in organisms that lack brains, nervous systems, or even neurons…and that aren’t even multicellular. This is precisely what we’d expect from evolutionary origins, that everything would have its source in simpler precursors. Furthermore, it’s a mistake to try and shoehorn those precursors into necessarily filling the same functions as their descendants today. Cooption is the rule. Even the brains of which we are so proud are byblows of more fundamental functions, like homeostasis, feeding, and locomotion.

Read the comments on this post…

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  2. Now hear this Deep in the ear, 95 percent of the cells that...
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]]> http://sciencenewsguide.info/2009/12/05/the-ubiquity-of-exaptation/feed/ 0 New gene findings will help guide treatment in infant leukemia http://sciencenewsguide.info/2009/12/05/new-gene-findings-will-help-guide-treatment-in-infant-leukemia/ http://sciencenewsguide.info/2009/12/05/new-gene-findings-will-help-guide-treatment-in-infant-leukemia/#comments Sat, 05 Dec 2009 17:30:05 +0000 BJS 27939 at http://www.scienceblog.com/cms Pediatric oncologists have identified specific genes, dubbed partner genes, that fuse with another gene to drive an often-fatal form of leukemia in infants. By more accurately defining specific partner genes, researchers expect to better predict which infants may benefit from particular treatments.

Link: 

http://www.chop.edu


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]]> Pediatric oncologists have identified specific genes, dubbed partner genes, that fuse with another gene to drive an often-fatal form of leukemia in infants. By more accurately defining specific partner genes, researchers expect to better predict which infants may benefit from particular treatments.

Link: 

http://www.chop.edu



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  3. Inherited risk factors increase odds of developing childhood acute lymphoblastic leukemia Scientists at St. Jude Children's Research Hospital have identified inherited...

]]> http://sciencenewsguide.info/2009/12/05/new-gene-findings-will-help-guide-treatment-in-infant-leukemia/feed/ 0 Febrile nitwits and the hacked climate change emails http://sciencenewsguide.info/2009/12/05/febrile-nitwits-and-the-hacked-climate-change-emails/ http://sciencenewsguide.info/2009/12/05/febrile-nitwits-and-the-hacked-climate-change-emails/#comments Sat, 05 Dec 2009 17:02:57 +0000 Pharyngula http://scienceblogs.com/pharyngula/2009/12/febrile_nitwits_and_the_hacked.php This is an excellent response to the furious and unfounded assertions of the right-wing denialists that have followed from the release of private email by climate change scientists.

I'm on a couple of private mailing lists where we exchange views on evolution, and <shock horror> we actually argue it times, and sometimes even disagree heatedly with one another. That climate scientists hash out disagreements in vigorous private debate is no surprise, and no sign of either a conspiracy or intent to mislead the public.

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]]> This is an excellent response to the furious and unfounded assertions of the right-wing denialists that have followed from the release of private email by climate change scientists.

I’m on a couple of private mailing lists where we exchange views on evolution, and <shock horror> we actually argue it times, and sometimes even disagree heatedly with one another. That climate scientists hash out disagreements in vigorous private debate is no surprise, and no sign of either a conspiracy or intent to mislead the public.

Read the comments on this post…

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  2. A poll to advocate a strong response to climate change Those kooky climate change denialists are at it again —...
  3. Military takes aim at climate change Climate change may need a military response from America, according...

]]> http://sciencenewsguide.info/2009/12/05/febrile-nitwits-and-the-hacked-climate-change-emails/feed/ 0 The World’s first and Best Online Casino http://sciencenewsguide.info/2009/12/05/the-world%e2%80%99s-first-and-best-online-casino/ http://sciencenewsguide.info/2009/12/05/the-world%e2%80%99s-first-and-best-online-casino/#comments Sat, 05 Dec 2009 16:55:45 +0000 realcash4u 27938 at http://www.scienceblog.com/cms The only thing better than video slots is free video slots,so Choose a game and then start playing. Our listings consist of the most reputable casino with the best free bonuses slots available. These games video slots free, all feature some form of a bonus, wild symbols, blinking lights, ringing bells, and superb flash animated graphics.


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  3. A cheat for better eyes: Up, Up, Down, Down, Left, Right, Left, Right, B, A, B, A, Start Video games might improve your eyesight, according to a paper...
]]> The only thing better than video slots is free video slots,so Choose a game and then start playing. Our listings consist of the most reputable casino with the best free bonuses slots available. These games video slots free, all feature some form of a bonus, wild symbols, blinking lights, ringing bells, and superb flash animated graphics.



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  3. A cheat for better eyes: Up, Up, Down, Down, Left, Right, Left, Right, B, A, B, A, Start Video games might improve your eyesight, according to a paper...

]]> http://sciencenewsguide.info/2009/12/05/the-world%e2%80%99s-first-and-best-online-casino/feed/ 0 I’m already sick of her http://sciencenewsguide.info/2009/12/05/im-already-sick-of-her/ http://sciencenewsguide.info/2009/12/05/im-already-sick-of-her/#comments Sat, 05 Dec 2009 15:19:50 +0000 Pharyngula http://scienceblogs.com/pharyngula/2009/12/im_already_sick_of_her.php This is going to go on for years and years, isn't it? Sarah Palin is going to keep on saying stupid things to keep herself in the news.

No one person has all the right answers. It takes a united nation, and it does take godly counsel, and it takes prayer and answers to prayer - and a collective humble heart of a nation seeking God's hand of protection and his blessings of prosperity.

I think if we can get back to that, our country will be a safer, more prosperous and healthier nation.

No, it won't. God does not provide, OK?

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]]> This is going to go on for years and years, isn’t it? Sarah Palin is going to keep on saying stupid things to keep herself in the news.

No one person has all the right answers. It takes a united nation, and it does take godly counsel, and it takes prayer and answers to prayer – and a collective humble heart of a nation seeking God’s hand of protection and his blessings of prosperity.

I think if we can get back to that, our country will be a safer, more prosperous and healthier nation.

No, it won’t. God does not provide, OK?

Read the comments on this post…

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]]> http://sciencenewsguide.info/2009/12/05/im-already-sick-of-her/feed/ 0 What did she expect? That Jesus would stop by and give her a turnip? http://sciencenewsguide.info/2009/12/05/what-did-she-expect-that-jesus-would-stop-by-and-give-her-a-turnip/ http://sciencenewsguide.info/2009/12/05/what-did-she-expect-that-jesus-would-stop-by-and-give-her-a-turnip/#comments Sat, 05 Dec 2009 15:12:49 +0000 Pharyngula http://scienceblogs.com/pharyngula/2009/12/what_did_she_expect_that_jesus.php Can you bear yet another case of religion-rationalized child abuse?

Over three months in 2006, as her five children grew more emaciated and listless by the day, Estelle Walker made no move to find a job, no effort to scrounge up a meal, her kids told a jury yesterday.

"We were supposed to wait for God to provide," said Walker's oldest daughter, now 21. "And that's what we did."

At one point, the daughter said, she and her siblings went 11 days without food. When police were at last summoned to the Sussex County cabin by neighbors, investigators found the children so malnourished they had difficulty talking.

You would think that after watching her own children waste away for months, she'd realize that god will not provide. Never has and never will.

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]]> Can you bear yet another case of religion-rationalized child abuse?

Over three months in 2006, as her five children grew more emaciated and listless by the day, Estelle Walker made no move to find a job, no effort to scrounge up a meal, her kids told a jury yesterday.

“We were supposed to wait for God to provide,” said Walker’s oldest daughter, now 21. “And that’s what we did.”

At one point, the daughter said, she and her siblings went 11 days without food. When police were at last summoned to the Sussex County cabin by neighbors, investigators found the children so malnourished they had difficulty talking.

You would think that after watching her own children waste away for months, she’d realize that god will not provide. Never has and never will.

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]]> http://sciencenewsguide.info/2009/12/05/what-did-she-expect-that-jesus-would-stop-by-and-give-her-a-turnip/feed/ 0 How to Get Best Car Loans? http://sciencenewsguide.info/2009/12/05/how-to-get-best-car-loans/ http://sciencenewsguide.info/2009/12/05/how-to-get-best-car-loans/#comments Sat, 05 Dec 2009 09:43:02 +0000 Jimothy318 27937 at http://www.scienceblog.com/cms
Used Car Loans,Guaranteed Car Loan,Best Car Loan

How to Get Best Car Loans?

When looking for a new car loan or a Used Car Financing, a very essential thing to think about is the car loans rates that are offered by the car financing institution. It is important to compare the rates provided by various finance companies so that a decision can be made on how comfortable you will be with the car loan interest rates. A guaranteed car loan rates is usually affected by 2 things: how much you are borrowing and the term of the No Credit Check Car Loan. Though these seem as typical points to weigh up of before choosing a best car loan rate , the process of calculating how much you ought to apply for and the payments that you will pay can be a daunting task. This is where a car loan calculator comes into the picture.


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]]>
Used Car Loans,Guaranteed Car Loan,Best Car Loan

How to Get Best Car Loans?

When looking for a new car loan or a Used Car Financing, a very essential thing to think about is the car loans rates that are offered by the car financing institution. It is important to compare the rates provided by various finance companies so that a decision can be made on how comfortable you will be with the car loan interest rates. A guaranteed car loan rates is usually affected by 2 things: how much you are borrowing and the term of the No Credit Check Car Loan. Though these seem as typical points to weigh up of before choosing a best car loan rate , the process of calculating how much you ought to apply for and the payments that you will pay can be a daunting task. This is where a car loan calculator comes into the picture.



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]]> http://sciencenewsguide.info/2009/12/05/how-to-get-best-car-loans/feed/ 0 Cell biology and computer science: a logical marriage http://sciencenewsguide.info/2009/12/04/cell-biology-and-computer-science-a-logical-marriage/ http://sciencenewsguide.info/2009/12/04/cell-biology-and-computer-science-a-logical-marriage/#comments Sat, 05 Dec 2009 05:24:12 +0000 Katrix 27936 at http://www.scienceblog.com/cms Anyone that has ever tried to write a rate equation for an enzymatic reaction in a biological process knows that it often disperses into a series of overwhelming, unintelligible numbers. While singular biological pathways are hard enough to interpret with such conventional methods, whole cell systems that integrate several pathways become that much harder.


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]]> Anyone that has ever tried to write a rate equation for an enzymatic reaction in a biological process knows that it often disperses into a series of overwhelming, unintelligible numbers. While singular biological pathways are hard enough to interpret with such conventional methods, whole cell systems that integrate several pathways become that much harder.



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]]> http://sciencenewsguide.info/2009/12/04/cell-biology-and-computer-science-a-logical-marriage/feed/ 0 Cell biology and computer science: a logical marriage http://sciencenewsguide.info/2009/12/04/cell-biology-and-computer-science-a-logical-marriage/ http://sciencenewsguide.info/2009/12/04/cell-biology-and-computer-science-a-logical-marriage/#comments Sat, 05 Dec 2009 05:24:12 +0000 Katrix 27936 at http://www.scienceblog.com/cms Anyone that has ever tried to write a rate equation for an enzymatic reaction in a biological process knows that it often disperses into a series of overwhelming, unintelligible numbers. While singular biological pathways are hard enough to interpret with such conventional methods, whole cell systems that integrate several pathways become that much harder.


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  3. Echoes of phlogiston in stem cell biology Before it was learned that matter burns by taking up...
]]> Anyone that has ever tried to write a rate equation for an enzymatic reaction in a biological process knows that it often disperses into a series of overwhelming, unintelligible numbers. While singular biological pathways are hard enough to interpret with such conventional methods, whole cell systems that integrate several pathways become that much harder.



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]]> http://sciencenewsguide.info/2009/12/04/cell-biology-and-computer-science-a-logical-marriage/feed/ 0 OMG <drool> http://sciencenewsguide.info/2009/12/04/omg-drool/ http://sciencenewsguide.info/2009/12/04/omg-drool/#comments Sat, 05 Dec 2009 02:58:40 +0000 Pharyngula http://scienceblogs.com/pharyngula/2009/12/omg_drool.php Be still my heart…Isabelli Rossellini dressed up as a squid demonstrating their mating ritual.

This is much more convincing than the God Equation.

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]]> Be still my heart…Isabelli Rossellini dressed up as a squid demonstrating their mating ritual.

This is much more convincing than the God Equation.

Read the comments on this post…

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]]> http://sciencenewsguide.info/2009/12/04/omg-drool/feed/ 0