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Retinal function measurement apparatus

Patent Number: RE44226
Publication Date: 2013-05-21
Inventor:

A retinal function measurement apparatus capable of measuring a retinal function accurately and precisely. The apparatus has a first image obtaining optical system for obtaining a tomographic image of a fundus by optical coherence tomography using low coherent light, the optical system including a light source emitting the low coherent light, a scanning unit scanning measurement light being a part of the emitted low coherent light on the fundus, an interference optical system for ...

Adenosine Areceptor antagonists

Patent Number: RE44205
Publication Date: 2013-05-07
Inventors: ; ; ; ; ; ; ;

Compounds having the structural formula I

or a pharmaceutically acceptable salt thereof, wherein

- R is optionally substituted phenyl, cycloalkenyl, or heteroaryl;
- X is alkylene or —C(O)CH₂—;
- Y is —N(R²)CH₂CH₂N(R)³)—, —OCH₂CH₂N(R²)—, —O—, —S—, —CH₂S—, ...

Field decoupling element for use with an implantable line and implantable medical device

Patent Number: 8447416
Publication Date: 2013-05-21
Inventors: ;

A field decoupling element for use with an implantable line with an elongated line body and a function conductor which extends in the longitudinal direction of the line body and acts to implement a medical function of the line, such that the field decoupling element is in electric contact with the function conductor in the use state connected to the line and reduces coupling of the function conductor to an external ...

Capsular device for esthetic and therapeutic body treatment

Patent Number: 8447415
Publication Date: 2013-05-21
Inventor:

A capsular device for esthetic and therapeutic treatment of a patient with emission of infrared together with negative ions, allowing easy elimination of toxins, heavy metals, preventive control of diseases and postsurgical therapeutic ...

Switched safety protection circuit for an AIMD system during exposure to high power electromagnetic fields

Patent Number: 8447414
Publication Date: 2013-05-21
Inventors: ; ; ; ;

An energy management system that facilitates the transfer of high frequency energy induced on an implanted lead or a leadwire includes an energy dissipating surface associated with the implanted lead or the leadwire, a diversion or diverter circuit associated with the energy dissipating surface, and at least one switch disposed between the diversion circuit and the AIMD electronics for diverting energy in the implanted lead or the leadwire through the diversion circuit to the energy ...

Configuring stimulation therapy using stimulation intensity

Patent Number: 8447413
Publication Date: 2013-05-21
Inventors: ; ; ;

Techniques for configuring electrical stimulation therapy utilizing one or more stimulation intensity values are described. In one example, a method includes receiving a stimulation intensity value that corresponds to an equal intensity function; determining a pulse width value and a pulse amplitude value based on the equal intensity function; and controlling delivery of electrical stimulation pulses with the determined pulse width value and amplitude value to a patient. A stimulation ...

Apparatus and methods for wireless communication via electrical pulses conducted by the interstitial tissues of the body for an active implantable medical device

Patent Number: 8447412
Publication Date: 2013-05-21
Inventor:

An active implantable medical device having wireless communication of data via electrical pulses conducted by the interstitial tissues of the body. This device (12, 14) includes a pair of electrodes (22, 24) and generates pulse trains consisting of a series of electrical pulses applied to the electrodes. The pulse train is modulated by digital information (data) that is produced by the device. A regulated current or voltage source (42) is used to generate (44, ...

Patient interaction with posture-responsive therapy

Patent Number: 8447411
Publication Date: 2013-05-21
Inventors: ; ; ; ;

In general, the disclosure relates to the delivery of therapy according to a detected posture state of a patient. The disclosure contemplates a variety of techniques for managing therapy delivered to a patent, including patient and clinician interaction with a medical device configured to deliver therapy according to posture state. In one example, the disclosure relates to a technique including obtaining an operational status of a therapy group from a medical device, wherein the medical ...

Trans-retinal drug delivery device

Patent Number: 8447410
Publication Date: 2013-05-21
Inventors: ;

Applicant has proposed a combination of the subretinal and epiretinal methods by placing the electronics external to the eye, entering the eye through the pars plana and the piercing the retina (retinotomy) from inside the eye to stimulate subreintally.

The present invention is an improved electrode array for subretinal stimulation. A hard polymer such as polyimide is biocompatible and strong for supporting an electrode array and supporting traces in a thin flex circuit array. In the ...

Electroneural interface for a medical implant

Patent Number: 8447409
Publication Date: 2013-05-21
Inventors: ;

Embodiments are generally directed to improving the interface between one or more electrode contacts of a medical implant and the neurons of a recipient of the medical implant. In an embodiment, a growth factor is applied to stimulate the growth of peripheral processes (also referred to as dendrites). Then an electric field is applied to direct the growth of the peripheral processes towards the electrode contact. Growing peripheral processes towards the electrode contacts may reduce the ...

Neurostimulation therapy manipulation

Patent Number: 8447408
Publication Date: 2013-05-21
Inventors: ;

A user, such as a clinician or the patient, uses a control device to manipulate at least one neurostimulation parameter. A mapping system uses a calibrated map to map the directional output of the control device to values of at least one stimulation parameter to allow the user to intuitively control the value of the parameter. In some embodiments, where a stimulation device is used to deliver spinal cord stimulation (SCS) therapy for example, the user manipulates a parameter to effect the ...

Method and system for detecting epileptogenesis

Patent Number: 8447407
Publication Date: 2013-05-21
Inventors: ; ;

Neuronal excitation and inhibition of the brain is tracked in the hippocampal CA1 network during a latent period, wherein biomarkers are observed which include a sustained increase in the firing rate of the excitatory postsynaptic field activity, paired with a subsequent decrease in the firing rate of the inhibitory postsynaptic field activity; the mean amplitude profiles of both fEPSP and fEPSP field potential activity during the latent period have characteristic shapes; both excitatory ...

Medical method and device for monitoring a neural brain network

Patent Number: 8447406
Publication Date: 2013-05-21
Inventors: ;

Bioelectrical signals may be sensed within the brain by two or more electrodes to determine characteristics of a function of the brain. The signals obtained by the electrodes may be plotted over time to determine whether the brain function exhibits a normal or an abnormal pattern. If the brain function exhibits an abnormal pattern, an implantable medical device may dynamically determine based on the abnormal pattern and a previously-obtained plot associated with normal brain function, an ...

Non-regular electrical stimulation patterns for treating neurological disorders

Patent Number: 8447405
Publication Date: 2013-05-21
Inventors: ;

Systems and methods for stimulation of neurological tissue generate stimulation trains with temporal patterns of stimulation, in which the interval between electrical pulses (the inter-pulse intervals) changes or varies over time. Compared to conventional continuous, high rate pulse trains having regular (i.e., constant) inter-pulse intervals, the non-regular (i.e., not constant) pulse patterns or trains that embody features of the invention provide a lower average ...

Device and implantation system for electrical stimulation of biological systems

Patent Number: 8447404
Publication Date: 2013-05-21
Inventors: ; ; ; ; ;

The present specification discloses devices and methodologies for the treatment of diurnal GERD. Individuals with GERD may be treated by implanting a stimulation device within the patient's lower esophageal sphincter and applying electrical stimulation to the patient's lower esophageal sphincter, in accordance with certain predefined protocols. The presently disclosed devices have a simplified design because they do not require sensing systems capable of sensing when a person is engaged in ...

Device and implantation system for electrical stimulation of biological systems

Patent Number: 8447403
Publication Date: 2013-05-21
Inventors: ; ; ; ; ;

The present specification discloses devices and methodologies for the treatment of nocturnal GERD. Individuals with nocturnal GERD may be treated by implanting a stimulation device within the patient's lower esophageal sphincter and applying electrical stimulation to the patient's lower esophageal sphincter, in accordance with certain predefined protocols. The presently disclosed devices have a simplified design because they do not require sensing systems capable of sensing when a person is ...

Zirconia to platinum assembly using a titanium connector

Patent Number: 8447402
Publication Date: 2013-05-21
Inventors: ;

The invention is a component assembly and method of hermetically bonding a ceramic part to a metal part by welding and brazing a component assembly comprised of metal parts, a ceramic part, and an intermediate metal ferrule. The ceramic part is preferably a hollow tube of partially-stabilized zirconia that is brazed to an alignment ferrule that is preferably titanium or a titanium alloy, such as Ti-6Al-4V. On one end the component assembly is brazed to an end cap for closure. On the other ...

Collecting posture information to evaluate therapy

Patent Number: 8447401
Publication Date: 2013-05-21
Inventors: ;

A medical device delivers a therapy to a patient. Posture events are identified, e.g., a posture of the patient is periodically determined and/or posture transitions by the patient are identified, and each determined posture event is associated with a current therapy parameter set. A value of at least one posture metric is determined for each of a plurality of therapy parameter sets based on the posture events associated with that therapy parameter set. A list of the therapy parameter sets ...

Systems and methods for use by an implantable medical device for controlling multi-site CRT pacing in the presence of atrial tachycardia

Patent Number: 8447400
Publication Date: 2013-05-21
Inventors: ; ; ;

Systems and methods are provided for use by implantable medical devices equipped to deliver multi-site left ventricular (MSLV) pacing. MSLV is associated with a relatively long post-ventricular atrial blanking (PVAB) period that might limit the detection of pathologic rapid organized atrial tachycardias (OAT). In one example, MSLV cardiac resynchronization therapy (CRT) pacing is delivered within a tracking mode. A possible atrial tachycardia is detected based on the atrial rate exceeding ...

System and method for managing detrimental cardiac remodeling

Patent Number: 8447399
Publication Date: 2013-05-21
Inventor:

A system and method for managing and inhibiting cardiac remodeling in MI patients. Bi-ventricular stimulation is constantly provided with and without sensing to encourage normal pumping of the heart on a consistent basis. Pulses are administered using an anodal pulse followed by a cathodal pulse to stimulate cardiac muscle contraction. Stem cells are administered to MI areas to encourage regeneration of cardiac tissue in the damaged area. Stimulation may be provided to both healthy and ...

Subcutaneous implantable cardioverter-defibrillator placement methods

Patent Number: 8447398
Publication Date: 2013-05-21
Inventors: ; ; ; ;

A subcutaneous cardiac device includes two electrodes and a stimulator that generates a pulse to the electrodes. The electrodes are implanted between the skin and the rib cage of the patient and are adapted to generate an electric field corresponding to the pulse, the electric field having a substantially uniform voltage gradient as it passes through the heart. The shapes, sizes, positions and structures of the electrodes are selected to optimize the voltage gradient of the electric field, ...

Systems, devices and methods used in verifying neural stimulation capture

Patent Number: 8447397
Publication Date: 2013-05-21
Inventors: ;

Various system embodiments comprise a neural stimulator, a premature ventricular contraction (PVC) event detector, a heart rate detector, an analyzer, and a controller. The neural stimulator is adapted to generate a stimulation signal adapted to stimulate an autonomic neural target. The analyzer is adapted to, in response to a PVC event signal from the PVC event detector, generate an autonomic balance indicator (ABI) as a function of pre-PVC heart rate data and post-PVC heart rate data. ...

Treating bacteria with electric fields

Patent Number: 8447396
Publication Date: 2013-05-21
Inventors: ;

Cells that are in the process division are vulnerable to damage by AC electric fields that have specific frequency and field strength characteristics. The selective destruction of rapidly dividing cells can therefore be accomplished by imposing an AC electric field in a target region for extended periods of time. Some of the cells that divide while the field is applied will be damaged, but the cells that do not divide will not be harmed. This selectively damages rapidly dividing cells like ...

Treating bacteria with electric fields

Patent Number: 8447395
Publication Date: 2013-05-21
Inventors: ;

Cells that are in the process division are vulnerable to damage by AC electric fields that have specific frequency and field strength characteristics. The selective destruction of rapidly dividing cells can therefore be accomplished by imposing an AC electric field in a target region for extended periods of time at particular frequencies with particular filed strengths. Some of the cells that divide while the field is applied will be damaged, but the cells that do not divide will not be ...

Physical conditioning system, device and method

Patent Number: 8447394
Publication Date: 2013-05-21
Inventors: ; ; ;

Various system embodiments comprise a neural stimulator and a controller. The neural stimulator is adapted to generate a stimulation signal adapted to elicit sympathetic activity at a neural target. The controller is adapted to control the neural stimulator to provide a physical conditioning therapy. The controller is adapted to control the neural stimulator to intermittently elicit sympathetic activity at the neural target. Other aspects and embodiments are provided ...

Iontophoretic electrode

Patent Number: 8447393
Publication Date: 2013-05-21
Inventors: ; ;

An electrode for an iontophoretic drug delivery system includes a retainer having a malleable characteristic. The retainer and a conductor are connected to a platform. The conductor and a dose controller are electrically coupled to the iontophoretic drug delivery system. A drug delivery matrix is operably connected to the platform and proximate the conductor wherein the conductor, the drug delivery matrix, and the dose controller cooperate to deliver a drug to a user when the electrode is ...

Brain-machine interface systems and methods

Patent Number: 8447392
Publication Date: 2013-05-21
Inventor:

A system and method for interfacing a brain with a machine. An exemplary embodiment of the present invention employs a vascular approach in which one or more nano-electrodes are deployed in vasculature having a close geometric relationship with proximal innervation. Each nano-electrode is preferably deployed in a blood vessel so that its sensing end is at or near a nerve passing close to or intersecting the blood vessel. The sensing end of each nano-electrode is adapted so as to be carried ...

Detection method for detecting QRS wave

Patent Number: 8447391
Publication Date: 2013-05-21
Inventor:

A detection method for detecting a QRS wave is disclosed. An electrocardiogram (ECG) signal is provided. The ECG signal is enhanced to generate a processed signal. A first crest of the processed signal is determined. Each crest following the first crest is defined as a second crest. The level of each second crest is higher than a first threshold value. The result of defining the second crest is utilized to determine whether the QRS wave has occurred and approached a first ...

Detecting hemodynamic stability during arrhythmia using the changes in atrial activation

Patent Number: 8447390
Publication Date: 2013-05-21
Inventors: ;

Detected changes in atrial activation can be used to discriminate between hemodynamically stable and hemodynamically unstable ...

Methods and systems to monitor and identify transient ischemia

Patent Number: 8447389
Publication Date: 2013-05-21
Inventors: ; ; ; ;

A system and method are provided for monitoring ischemic development. The system and method identify a non-physiologic event and obtain cardiac signals along multiple sensing vectors, wherein at least a portion of the sensing vectors extend to or from electrodes located proximate to the left ventricle. The system and method monitor a segment of interest in the cardiac signals obtained along the multiple sensing vectors to identify deviations in the segment of interest from a baseline. The ...

Apparatus and method for biological observation using sound waves and light

Patent Number: 8447388
Publication Date: 2013-05-21
Inventor:

A biological observation apparatus according to the present application includes a sound wave radiating unit that radiates a sound wave into an object to be examined in living tissue, a light radiating unit that radiates light into the object, a light interfering unit that makes the light radiated from the light radiating unit interfere with light reflected from an area where the sound wave reaches and radiates interference light, a light detector that detects the interference light ...

Method and apparatus for real-time tumor tracking by detecting annihilation gamma rays from low activity position isotope fiducial markers

Patent Number: 8447387
Publication Date: 2013-05-21
Inventors: ; ;

Method and apparatus for real-time tracking of a target in a human body. In one embodiment of the invention, positron emission marker may be implanted into a target, the positron emission marker having a low activity positron isotope. In one embodiment, annihilation gamma rays associated with the low activity positron isotope may be detected using a plurality of position-sensitive detectors. In another embodiment, the target may be tracked in real-time based on a position of the positron ...

Marker or filler forming fluid

Patent Number: 8447386
Publication Date: 2013-05-21
Inventors: ; ;

A system for at least partially filling and marking a cavity at a site within a patient's body includes a marker delivery device having a chamber configured to contain a marking substance and having a mechanism configured to expel the marking substance. A quantity of the marking substance is contained within the chamber of the marker delivery device. The marking substance is configured to at least partially fill the cavity and form therein a porous bioabsorbable body. A delivery tube is ...

Handheld medical microwave radiometer

Patent Number: 8447385
Publication Date: 2013-05-21
Inventors: ; ; ; ; ; ;

A microwave handheld radiometer for measuring subsurface tissue temperature of a subject includes a microwave antenna disposed relative to a handheld radiometer housing and adapted to electromagnetically couple to a skin surface of a subject, a circulator having a first circulator input and a second circulator input, wherein the first circulator input is electrically coupled to said antenna via a microwave feedline. A switch is electrically disposed between the antenna and an microwave ...

Method and system for performing biopsies

Patent Number: 8447384
Publication Date: 2013-05-21
Inventors: ; ; ; ; ;

A method and system for performing biopsies can include an imaging system for obtaining diagnostic images of a target region; a tracking system; a probe having a deployable biopsy needle for performing a biopsy procedure where the tracking system generates tracking information for at least one of the probe and the biopsy needle; an ultrasound imaging system for obtaining ultrasound imaging of the target region; and a computer in communication with the tracking system, the imaging system and ...

System and method for providing 2-dimensional computerized-tomography image corresponding to 2-dimensional ultrasound image

Patent Number: 8447383
Publication Date: 2013-05-21
Inventors: ; ;

Embodiments for providing a 2-dimensional (D) computerized-tomography (CT) image corresponding to a 2-D ultrasound image through image registration between 3-D ultrasound and CT images are disclosed. An imaging system comprises a CT imaging unit, an ultrasound image forming unit, a storing unit, a processor and a display unit. The processor extracts the 2-D CT image from the 3-D ultrasound-CT registered image by performing a rigid-body transform upon the 3-D ultrasound image and calculating ...

Positioning system and method of position detecting

Patent Number: 8447382
Publication Date: 2013-05-21
Inventors: ; ;

A body-insertable device including a resonance circuit for emitting a resonance magnetic field by being induced by a drive magnetic field received from the outside. An external device for deriving position information of the resonance circuit by using a detection signal of detected resonance magnetic field. The external device includes a drive coil driving unit for outputting a drive signal having a predetermined frequency, a drive coil for receiving the output drive signal and generating ...

Method and apparatus for controlling a contrast agent injection for magnetic resonance imaging

Patent Number: 8447381
Publication Date: 2013-05-21
Inventors: ; ; ; ;

In a method and magnetic resonance system for controlling a contrast agent injector used with a magnetic resonance imaging scanner of the system, a user interface is displayed at the control panel of the scanner, for configuring the operating parameters of the injector connected to the magnetic resonance imaging scanner and for controlling the injector in accordance with the operating parameters configured on said user interface, from the scanner control ...

Method for diagnosis of functional lung illnesses

Patent Number: 8447380
Publication Date: 2013-05-21
Inventors: ; ;

In a method for diagnosing functional lung illnesses, image exposures of the lungs are obtained at various phase points in time of the respiration of a subject, such as at maximum inhalation and maximum expiration, and the image exposures are segmented and at least two of the image exposures are compared on a segment-by-segment basis to identify a change in tissue density between the compared segments, as an indicator of lung ...

Detection, measurement, and imaging of cells such as cancer and other biologic substances using targeted nanoparticles and magnetic properties thereof

Patent Number: 8447379
Publication Date: 2013-05-21
Inventor:

The present invention can provide a method of determining the presence, location, quantity, or a combination thereof, of a biological substance, comprising: (a) exposing a sample to a plurality of targeted nanoparticles, where each targeted nanoparticle comprises a paramagnetic nanoparticle conjugated with one or more targeting agents that preferentially bind with the biological substance, under conditions that facilitate binding of the targeting agent to at least one of the one or more ...

System and method of capturing images

Patent Number: 8447378
Publication Date: 2013-05-21
Inventor:

A system and methods for capturing, displaying, and viewing representations of progressions of anatomical structures and associated digital images is disclosed. A processor-based system is used to generate and store digital images of anatomical structures such as teeth of a dental patient. Any one digital image is stored as an image shot within a progression of image shots. The progression of image shots may correspond to a particular region of interest or study being performed by a dental ...

Cardiac mapping catheter

Patent Number: 8447377
Publication Date: 2013-05-21
Inventors: ;

A multi electrode catheter for non contact mapping of the heart having independent articulation and deployment ...

Analyte sensor

Patent Number: 8447376
Publication Date: 2013-05-21
Inventors: ; ; ;

Systems and methods of use for continuous analyte measurement of a host's vascular system are provided. In some embodiments, a continuous glucose measurement system includes a vascular access device, a sensor and sensor electronics, the system being configured for insertion into communication with a host's circulatory ...

Methods and dressing systems for promoting healing of injured tissue

Patent Number: 8447375
Publication Date: 2013-05-21
Inventor:

A dressing system is disclosed which has a sponge and a near infrared spectroscopy sensor positioned adjacent to the sponge for monitoring oxygenation levels of tissue adjacent to the sponge. The dressing system may further include a tube coupled to the sponge for removing fluid from the sponge. The dressing system comprises: a sponge; and a tensioning system coupled to the sponge. The tensioning system further comprises a central longitudinal member coupled to the sponge; and at least one ...

Systems and methods for determining blood oxygen saturation values using complex number encoding

Patent Number: 8447374
Publication Date: 2013-05-21
Inventor:

The disclosure includes pulse oximetry systems and methods for determining point-by-point saturation values by encoding photoplethysmographs in the complex domain and processing the complex signals. The systems filter motion artifacts and other noise using a variety of techniques, including statistical analysis such as correlation, or phase ...

Apparatus and method for measuring a characteristic of a composition reactive to a magnetic field

Patent Number: 8447373
Publication Date: 2013-05-21
Inventor:

A system that incorporates teachings of the present disclosure may include, for example, a sensor having a pulse oximeter sensor to measure an oxygen saturation level in a liquid, a magnetic source coupled to the pulse oximeter sensor, and a controller to control the pulse oximeter sensor and the magnetic source, and to measure a mechanical effect on the liquid responsive to the magnetic source applying a magnetic field to the liquid. Additional embodiments are ...

Monitoring a vital parameter of a patient with “in-situ” modulation scheme to avoid interference

Patent Number: 8447372
Publication Date: 2013-05-21
Inventor:

The invention relates to a method of monitoring a vital parameter of a patient by measuring attenuation of light emitted onto tissue of the patient, comprising the following steps: modulating the light with a modulation frequency or/and a modulation code; emitting the modulated light onto the tissue of the patient; collecting light which is transmitted through the tissue or/and which is reflected from the tissue; demodulating the collected light; analyzing the demodulated collected light ...

Extrusion bonded laminates for absorbent articles

Patent Number: 8445744
Publication Date: 2013-05-21
Inventors: ; ; ; ;

An absorbent article of the present invention may comprise a topsheet, an outer cover, and an absorbent core disposed therebetween. The outer cover may comprise an extrusion bonded laminate. The EBL may comprise a multi-layer coextruded elastomeric film and a nonwoven. The film may comprise a core layer, a first outer layer, and a second outer layer, wherein the core layer is between the first and second outer layers. The nonwoven may comprise fibers and/or filaments. The first outer layer ...

Wearable article enhancing awareness of urination

Patent Number: 8445743
Publication Date: 2013-05-21
Inventors: ; ;

An absorbent article for wearing about the torso and including a member that supports the movement of urine in an x-y plane to enhance the wearer's awareness that urination has occurred by increasing the wetted area contacting the wearer's skin. The member has a permeable body-facing layer and an impermeable layer disposed in a face-to-face arrangement with the permeable layer and preferably is held in close contact with the wearer's skin during ...

Wound dressing and process for producing the same and use thereof

Patent Number: 8445742
Publication Date: 2013-05-21
Inventor:

A process for producing a wound dressing was provided having steps of: spinning an aqueous stock containing natural polymeric materials into a spin formation solution to form a wet polymeric spin; immersing the wet polymeric fiber into a softening reagent to obtain a softened wet polymeric spin; immersing the softened wet polymeric spin into a volatile reagent to expelling moisture in the softened wet polymeric fiber to form a polymeric fiber; forming a non-woven fabric of the polymeric ...