patentstorm.us

Preformed thermoplastic indicia for airport runways and taxiways

Patent Number: RE44184
Publication Date: 2013-04-30
Inventors: ;

Disclosed is an alkyd resin-based pre-manufactured thermoplastic airport runway signage that is applied in relatively large sections onto an airport runway. The pre-manufactured preformed thermoplastic formed as a continuous sheet and wound onto a take-up spool. The runway surface is prepared with a CCS an epoxy primer and the preformed thermoplastic is unwound from the take-up spool and positioned onto the runway surface. When the pre-manufactured thermoplastic signage is in a desired ...

Methods, compositions and articles of manufacture for contributing to the treatment of cancers

Patent Number: 8440620
Publication Date: 2013-05-14
Inventors: ; ;

Methods, compositions and articles of manufacture for contributing to the treatment of cancers, including solid tumors, are disclosed. The methods, compositions and articles of manufacture can utilize an endothelin B agonist (ET_B) to enhance the delivery and resulting efficacy of a chemotherapeutic ...

Composition for the attachment of implants to collagen or other components of biological tissue

Patent Number: 8440618
Publication Date: 2013-05-14
Inventors: ; ; ; ;

The present invention relates to a novel composition comprising an implant, scaffold or construct bound to a biological or chemical moiety. The bound moiety has the ability to bind to a component of the extracellular matrix of biological tissue, allowing the implant to be bound to the biological tissue in a short period of time after implantation. The invention also relates to the use and manufacture of this novel composition, as well as a novel use for the protein ...

Mapkap kinase-2 as a specific target for blocking proliferation of P53-defective cells

Patent Number: 8440610
Publication Date: 2013-05-14
Inventors: ; ;

The present invention relates to compounds and pharmaceutical compositions for treating cellular proliferative disorders, e.g., in patients having one or more p53-deficient cells, screening assays for identifying such compounds, and methods for treating such ...

Alcohol metabolizing assisting supplement

Patent Number: 8440242
Publication Date: 2013-05-14
Inventor:

A alcohol metabolizing assisting supplement includes a mixture which includes humic and fulvic acids, L-Cysteine, L-Glutamine, thiamine mononitrate, and vitamins. The mixture is ingested after the consumption of alcohol to assist the body in quickly metabolizing the alcohol and to resist the negative effects of metabolizing ...

Alcohol metabolizing assisting supplement

Patent Number: 8440241
Publication Date: 2013-05-14
Inventor:

Method for treating ocular demodex

Patent Number: 8440240
Publication Date: 2013-05-14
Inventors: ;

The present invention relates to a method for treating a disorder chosen from ocular Demodex, Demodex-induced blepharitis, rosacea, acne, and meibomian gland dysfunction in a patient in need thereof, comprising administering to the patient a composition comprising a therapeutically effective amount of a substance chosen from at least one of an isoprenoidal essential oil such as Tea Tree Oil; Terpinen-4-ol; Carvone; alpha-Terpineol; Cardinene; d-Carvone; l-Carvone; gamma-Terpinene; ...

Formulations and treatments for trichology

Patent Number: 8440239
Publication Date: 2013-05-14
Inventor:

A formulation for trichological treatment of a patient including, in a dosage in the range of 3 g to 8 g: phytosterols in the range of 200 mg to 2500 mg; the quantitative equivalent of Polygonum multiflorum root 4:1 in 70% EW in the range of 600 mg to 2600 mg; methylsulfonylmethane in the range of 500 mg to 2000 mg; and bovine colostrum in the range of 500 m to 2000 ...

Sulfated derivative of polysaccharide, preparation method and antitumor use thereof

Patent Number: 8440238
Publication Date: 2013-05-14
Inventor:

The present invention discloses a sulfated derivative of polysaccharide extracted from gastrodia elata BL., the preparation method thereof and the use thereof in preparing antineoplastic medicaments, wherein, the gastrodia elata polysaccharide has the following structure:

- wherein, x and y are each an integer, and x+y=16,
- “n” is and integer, and
- the mean molecular weight of ...

Botanical anti-acne formulations

Patent Number: 8440237
Publication Date: 2013-05-14
Inventors: ;

Disclosed is a topical skin care composition and corresponding methods for their use comprising Arctium lappa (Burdock) root extract, Epilobium angustifolium (Canadian Willowherb) extract, or Cystoseira amentacea/Caespitosa Brachycarpa extract, or any combination ...

Calcium carbonate granulation

Patent Number: 8440236
Publication Date: 2013-05-14
Inventors: ; ; ;

Highly compactable granulations and methods for preparing highly compactable granulations are disclosed. More particularly, highly compactable calcium carbonate granulations are disclosed. The granulations comprise powdered materials such as calcium carbonate that have small median particle sizes. The disclosed granulations are useful in pharmaceutical and nutraceutical tableting and provide smaller tablet sizes upon compression than previously ...

Amniotic membrane preparations and purified compositions and therapy for scar reversal and inhibition

Patent Number: 8440235
Publication Date: 2013-05-14
Inventors: ; ;

Compositions having a combination of specific biological components have been found to exert a number of useful effects in mammalian cells, including modulating TGF β signaling, apoptosis, and proliferation of mammalian cells, as well as decreasing inflammation in mice. These components can be obtained commercially, or can be prepared from biological tissues such as placental tissues. Placental amniotic membrane (AM) preparations described herein include AM pieces, AM extracts, AM jelly, ...

Standardized bee venom preparation

Patent Number: 8440234
Publication Date: 2013-05-14
Inventor:

Bee venom may be administered in a standardized formulation with or without relatively small amounts of anesthetic. In particular, the results of the combination of venom and anesthetic dramatically decreased pain and discomfort for patients undergoing ...

Compositions against rotavirus infection and processes for producing the same

Patent Number: 8440233
Publication Date: 2013-05-14
Inventors: ; ;

The present inventors discovered that microfiltration retentates of whey, and products obtained by treating whey using centrifugation and/or ammonium sulfate precipitation, have the activity of inhibiting rotavirus infection. In one embodiment, the present invention provides a method of preventing rotavirus infection, comprising administering to a subject a composition that comprises a whey cream serum obtained by treating whey by centrifugation, or a dehydrated product thereof, wherein the ...

Methods of treatment using a gastric retained gabapentin dosage

Patent Number: 8440232
Publication Date: 2013-05-14
Inventors: ; ;

A method of treatment for epilepsy and other disease states is described, which comprises delivery of gabapentin in a gastric retained dosage ...

Swellable particles for drug delivery

Patent Number: 8440231
Publication Date: 2013-05-14
Inventor:

Swellable particles for delivery of a drug or other working agent to the pulmonary system are provided. The swellable particles include a dehydrated (dry) aerodynamic particle diameter of 5 μm or less to enable delivery to the respiratory tract, such as for example to the tracheo-bronchial airways of the upper respiratory tract and/or to the alveolic regions of the deep lung, and a hydrated particle diameter that is greater than 6 μm volume mean diameter to retard or prevent their ...

Formulation based on micronized natural calcite mineral as a plant booster and mineral fertilizer

Patent Number: 8440230
Publication Date: 2013-05-14
Inventors: ;

The present invention is related to a formulation based on micronized natural calcite mineral consisting of: A. mineral part which is characterized: (i) by the particle size with diameter smaller than 5 μm, where the distribution of particle size is such that minimum of 10% of particles are with diameter under 900 nm, with total surface of particles greater than 3.2 m²/g, and with total porous volume greater than 0.012 cm³/g, and by composition: (ii) CaCO₃, ...

Hollow silica nanospheres and methods of making same

Patent Number: 8440229
Publication Date: 2013-05-14
Inventors: ; ; ;

The disclosure provide hollow nanospheres and methods of making and using the same. The methods and compositions of the disclosure are useful for drug delivery and gene ...

Adsorbent for an oral administration, and agent for treating or preventing renal or liver disease

Patent Number: 8440228
Publication Date: 2013-05-14
Inventors: ;

An adsorbent for an oral administration, comprising a spherical activated carbon wherein an average particle diameter is 50 to 200 μm, a specific surface area determined by a BET method is 700 m²/g or more, and a bulk density is less than 0.54 g/mL is disclosed. The adsorbent for an oral administration has a high adsorbability, and is capable of adsorbing a large amount of toxins during a retention period in an intestine, and of remarkably increasing an adsorption amount of ...

Biodegradable, non-toxic biological adhesive and methods for use in abdominal surgery

Patent Number: 8440227
Publication Date: 2013-05-14
Inventor:

A biological adhesive formulation comprising dextrin, at least one adhesiveness modifier agent, and at least one antibiotic is suitable for promoting healing of tissue in a patient, for example, to prevent anastomosis of a surgical wound in the digestive system of a patient, and for affixing prosthesis during a hernia operation in a patient and occluding a fistula within a ...

Solvent/polymer solutions as suspension vehicles

Patent Number: 8440226
Publication Date: 2013-05-14
Inventors: ; ; ; ; ; ;

A nonaqueous, single-phase vehicle that is capable of suspending an active agent. The nonaqueous, single-phase vehicle includes at least one solvent and at least one polymer and is formulated to exhibit phase separation upon contact with an aqueous environment. The at least one solvent may be selected from the group consisting of benzyl benzoate, decanol, ethyl hexyl lactate, and mixtures thereof and the at least one polymer may be selected from the group consisting of a polyester, ...

Process of making flowable hemostatic compositions and devices containing such compositions

Patent Number: 8440225
Publication Date: 2013-05-14
Inventors: ; ;

The present invention is directed to processes of making flowable hemostatic compositions and devices that include the flowable hemostatic composition disposed therein, where a volume of a biocompatible liquid, a volume of a biocompatible gas, and an amount of solid particles of a biocompatible polymer are mixed together to form a substantially homogenous composition including a discontinuous gas phase and the solid particles substantially homogenously dispersed throughout a continuous ...

Multi-component pharmaceutical dosage form

Patent Number: 8440224
Publication Date: 2013-05-14
Inventors: ; ; ; ; ;

A multi-component pharmaceutical dosage form comprising a plurality of drug substance—containing sub-units, being capsule compartments and/or solid sub-units comprising a solid matrix of a polymer which contains a drug substance, the sub-units being connected together in the assembled dosage form by a weld between parts of the assembled dosage ...

Sustained release pharmaceutical compositions comprising quetiapine in non-gellable polymers

Patent Number: 8440223
Publication Date: 2013-05-14
Inventor:

A sustained release dosage form comprising Quetiapine or a pharmaceutically acceptable salt, polymorphs, solvates, hydrates thereof and one or more non-gellable release controlling polymer and one or more pharmaceutically acceptable excipient(s). A sustained release dosage form comprising first granulation comprising Quetiapine or its pharmaceutically acceptable salts, polymorphs, solvates, hydrates thereof and one or more release controlling material; and second granulation comprising one ...

Reservoir system with closed membrane

Patent Number: 8440222
Publication Date: 2013-05-14
Inventors: ; ;

A dermal or transdermal therapeutic system comprising a reservoir that contains at least one active substance, an active substance-permeable membrane which delimits the active-substance reservoir, and a closing layer. The closing layer is impermeable to the active substance at a temperature lying below the skin temperature while being permeable at skin temperature and ...

Transdermal drug delivery method and system

Patent Number: 8440221
Publication Date: 2013-05-14
Inventors: ; ; ;

The invention concerns a transdermal delivery system for controlled dispensing of an active substance to and through a porous surface. A certain amount of fluid comprising at least one active substance and at least one solvent is dispensed into an administration reservoir. In the administration reservoir the at least one solvent is separated from the administration reservoir by a solvent recovery means such that the active substance achieves a certain level on an interface device which is ...

Transdermal analgesic systems with reduced abuse potential

Patent Number: 8440220
Publication Date: 2013-05-14
Inventors: ; ; ; ;

A transdermal analgesic system having reduced potential for abuse, wherein the system provides for the controlled release of the antagonist at a rate sufficient to provide an abuse limiting release rate ratio of the antagonist to the analgesic when the dosage form is subject to abuse is ...

Reduced-odor thiol compositions

Patent Number: 8440219
Publication Date: 2013-05-14
Inventor:

The present invention provides compositions for and methods of delivering a therapeutically-effective dose of a malodorous, sulfide or disulfide group-containing compound, for example glutathione (reduced) and/or glutathione disulfide, in a vehicle that is effective to reduce the unpleasant odor and/or taste of the compound. The invention further provides methods for reducing the amount of oxidation occurring when sulfide group-containing compounds, such as glutathione, are incorporated ...

Method for enhancing milk production

Patent Number: 8440218
Publication Date: 2013-05-14
Inventor:

The present invention concerns a method of enhancing milk production by a ruminant that includes providing a feed that contains sorbitol and at least one additional feed component, and orally feeding the feed to the ruminant, the ruminant ingesting about 100 grams, or less, of sorbitol per ...

Method and system with contact lens product for treating and preventing adverse eye conditions

Patent Number: 8440217
Publication Date: 2013-05-14
Inventor:

A contact lens product, a method and system for forming the contact lens product, and a method of using the contact lens product. The contact lens product includes a soft disposable contact lens loaded with a drug and the carriers which carry the drug. The lens has a mechanical and optical structure formed by the core polymer included within the lens. The contact lens product is configured to have the drug released from its carrier continuously into an eye of a mammal while the contact lens ...

Sustained release intraocular implants and related methods

Patent Number: 8440216
Publication Date: 2013-05-14
Inventors: ;

Biocompatible intraocular implants include a steroid and a polymer associated with each other to facilitate release of the steroid into an eye for a period of time greater than about two months. The steroid may be associated with a biodegradable polymer matrix, such as a matrix of a two biodegradable polymers. Or, the steroid may be associated with a polymeric coating having one or more openings effective to permit the steroid to be released into an external environment. The implants may be ...

Absorbable polymer formulations

Patent Number: 8440215
Publication Date: 2013-05-14
Inventors: ;

A co-polyester which includes the reaction product of a polycondensation polyester and epsilon-caprolactone, wherein the polycondensation polyester comprises the reaction product of diglycolic acid and/or a derivative thereof and a diol. The co-polyester is injectable and absorbable into animal, such as human, tissue and can be used for facial cosmetic or reconstructive surgery of soft tissue. Another embodiment is directed to a method for preventing adhesion using a co-polyester comprising ...

Medical devices for therapeutic agent delivery with polymeric regions that contain copolymers having both soft segments and uniform length hard segments

Patent Number: 8440214
Publication Date: 2013-05-14
Inventors: ; ;

Implantable or insertable medical devices are described, which include one or more polymeric regions and one or more therapeutic agents. The polymeric regions, which regulate the release of one or more therapeutic agent from the medical device, contain copolymer molecules, each of which includes one or more soft segments and one or more uniform hard segments (e.g., polyamide segments that do not vary in length from molecule to molecule, among ...

Pesticides formulations

Patent Number: 8440213
Publication Date: 2013-05-14
Inventors: ; ; ;

Concentrated microemulsions comprising: 1) 10-25 parts by weight of a pesticide with a solubility in water at 20° C. lower than 1% l by weight and having a melting point from 10° C. to 60° C.; 2) 8-25 parts by weight of one or more solvents containing oxygen atoms, having a solubility in water at 20° C. lower than 5% by weight and the Hildebrand solubility parameter in the range 16-21 MPa_1/2; 3) 10-20 parts by weight of a polyol; 4) 10-25 parts by weight of one or more non ...

Compositions for treating water systems

Patent Number: 8440212
Publication Date: 2013-05-14
Inventors: ;

The present invention relates to treatment of water, and more specifically to treatment of water using a stable formulation of polyhexamethylene biguanide (PHMB) and a liquid or solid zinc salt for the application and prevention algae in recirculated and stagnant water systems. The invention also encompasses methods of treating water that already contains ...

Cosmetic composition comprising a volatile fatty phase

Patent Number: 8440211
Publication Date: 2013-05-14
Inventor:

The invention relates to a composition comprising, in a physiologically acceptable medium, a volatile silicone fatty phase comprising at least one non-cyclic volatile silicone oil, wherein the volatile silicone fatty phase has an evaporation profile such that the mass of the at least one volatile silicone oil evaporated after 30 minutes is from 2 mg/cm²to 9 mg/cm². The invention also relates to making up and caring for human keratin materials using the inventive ...

Stabilized pharmaceutical product

Patent Number: 8440210
Publication Date: 2013-05-14
Inventor:

Use of an adsorbent and a sealed package (e.g. an overwrap) to protect a pharmaceutical product in a solid state in the presence of a reducing ...

Adhesive for medical applications and means for haemostasis

Patent Number: 8440209
Publication Date: 2013-05-14
Inventors: ; ; ; ; ;

The invention relates to adhesives for medical applications and methods of their preparation and ...

Chlamydial antigens as reagents for diagnosis and treatment of chlamydial infection and disease

Patent Number: 8440208
Publication Date: 2013-05-14
Inventor:

The present invention provides Chlamydia proteins and methods of use in diagnostic and detection assays as well as in treatment and immunization ...

Live bacterial vaccines for viral infection prophylaxis or treatment

Patent Number: 8440207
Publication Date: 2013-05-14
Inventor:

A live bacterium, having a DNA construct stabilized against transduction of other bacteria, having a promoter sequence and encoding a fusion peptide, comprising a bacterial secretion peptide portion and a non-bacterial immunogenic polypeptide portion, having a nucleotide sequence coding for the non-bacterial immunogenic polypeptide portion which has at least one codon optimized for bacterial expression. The bacterium has a secretion mechanism which interacts with at least the bacterial ...

Methods for producing an immune response to tuberculosis

Patent Number: 8440206
Publication Date: 2013-05-14
Inventor:

Methods for producing an immune response to Mycobacterium tuberculosis (Mtb) are disclosed herein. In several examples, the immune response is a protective immune response. In additional embodiments, methods are disclosed for preventing an infection with Mtb, or treating an infection with Mtb. Pharmaceutical compositions for the prevention and/or treatment of tuberculosis are also ...

Streptococcal C5A peptidase vaccine

Patent Number: 8440205
Publication Date: 2013-05-14
Inventors: ;

Novel vaccines for use against β-hemolytic Streptococcus colonization or infection are disclosed. The vaccines contain an immunogenic amount of a variant of streptococcal C5a peptidase (SCP). Also disclosed is a method of protecting a susceptible mammal against β-hemolytic Streptococcus colonization or infection by administering such a vaccine. Enzymatically inactive SCP, and polynucleotides encoding these SCP proteins are further ...

Subtype of neurotoxin type A and uses thereof

Patent Number: 8440204
Publication Date: 2013-05-14
Inventors: ; ; ; ;

A novel subtype of type A botulinum neurotoxin (BoNT/A) is disclosed in the application. Methods to purify the neurotoxin as well as uses thereof are also ...

Methods of immunizing pregnant heifers at three months of gestation

Patent Number: 8440203
Publication Date: 2013-05-14
Inventors: ; ;

The present invention discloses methods for protecting newborn calves against neonatal diarrhea by vaccinating pregnant cows and/or pregnant heifers, while minimizing the number of separate occasions producers are required to assemble the ...

Induction of an immune response against dengue virus using the prime-boost approach

Patent Number: 8440202
Publication Date: 2013-05-14
Inventors: ; ;

The invention relates to methods for the induction of an immune response to dengue virus. The method of inducing an immune response against dengue virus comprises administration of a non-replicating immunogen followed by a boost with a tetravalent live attenuated viral vaccine. Another aspect of the inventive subject matter is a method of inducing an immune response against dengue virus using a heterologous prime-boost regimen with the priming immunogen comprising a DNA expression system, ...

Stabilized bioactive peptides and methods of identification, synthesis, and use

Patent Number: 8440201
Publication Date: 2013-05-14
Inventor:

An intracellular selection system allows screening for peptide bioactivity and stability. Randomized recombinant peptides are screened for bioactivity in a tightly regulated expression system, preferably derived from the wild-type lac operon. Bioactive peptides thus identified are inherently protease- and peptidase-resistant. Also provided are bioactive peptides stabilized by a stabilizing group at the N-terminus, the C-terminus, or both. The stabilizing group can be a small stable protein, ...

Non-anaphylactic forms of grass pollen Ph1 p 6 allergen and their use

Patent Number: 8440200
Publication Date: 2013-05-14
Inventors: ; ; ; ; ; ;

Methods for desensitization of a mammal suffering from IgE mediated allergy comprise the steps of: administering to said mammal a therapeutically effective amount of an immunogenic and hypoallergenic composition which comprises (i) a Phl p 6 molecule having an N-terminal truncation which makes the molecule at least lack IgE binding capacity, and/or (ii) a Phl p 6 molecule having a C-terminal truncation which makes the molecule at least lack IgE binding capacity, wherein the molecules of (i) ...

Methods for mobilizing mesenchymal stem cells in a patient

Patent Number: 8440199
Publication Date: 2013-05-14
Inventors: ;

The current invention provides a method for mobilizing endothelial progenitor cells (EPC) and/or mesenchymal stem cells (MSC) in a patient, wherein the method comprises the steps of (i) administering a vascular endothelial growth factor receptor (VEGFR) agonist to the patient; and (ii) administering an antagonist of CXCR4 to the patient. Also provided are uses of EPC and MSC harvested using the methods of the ...

Compositions and methods for wound healing

Patent Number: 8440198
Publication Date: 2013-05-14
Inventor:

The present invention is related to the field of wound healing or tissue regeneration due to disease (i.e., for example, cardiovascular diseases, osetoarthritic diseases, or diabetes). In particular, the present invention provides compositions and methods comprising molecules with linked α-gal epitopes for induction of an inflammatory response localized within or surrounding damaged tissue. In some embodiments, the present invention provides treatments for tissue repair in normal subjects ...

KID3 and KID3 antibodies that bind thereto

Patent Number: 8440197
Publication Date: 2013-05-14
Inventors: ; ;

The invention provides the identification and characterization of disease and cancer-associated epitope, KID3. The invention also provides a family of monoclonal antibodies that bind to KID3, methods of diagnosing and treating various human cancers and diseases that express ...