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Method to measure serum biomarkers for the diagnosis of liver fibrosis

Patent Number: 8110409
Publication Date: 2012-02-07
Inventors: Liu, Ning; Chen, Zhong; Li, Yancun

This invention discloses using SPR technology to simultaneously and quantitatively measure the concentrations of different liver fibrosis-associated serum biomarkers in a serum sample, which can be used for the diagnosis of liver fibrosis. It also discloses an efficient formula to make a mixed SAM that can greatly enhance the immobilization ability of the metal surface in SPR based techniques, which is good for the immobilization of relevant antibodies used for the detection of liver ...

Method for quantitative detection of diabetes related immunological markers

Patent Number: 8110408
Publication Date: 2012-02-07
Inventors: Liu, Ning; Chen, Zhong; Li, Yancun

This invention discloses using SPR technology to simultaneously and quantitatively measure the concentrations of diabetes related immunological makers in a serum sample, which can be used to diagnose and/or early diagnose diabetes as well as to predict the onset risk of diabetes in first-degree relatives. It also discloses an efficient formula to make a mixed SAM that can greatly enhance the immobilization ability of the metal surface in SPR based techniques, which is good for the ...

Fluorescent semiconductor microparticle assembly, fluorescent labeling agent assembly for biological substance, and bioimaging method and biological substance analysis method using the assemblies

Patent Number: 8110407
Publication Date: 2012-02-07
Inventors: Hoshino, Hideki; Tsukada, Kazuya; Okada, Hisatake

Disclosed is a fluorescent semiconductor microparticle assembly comprising at least three kinds of fluorescent semiconductor microparticles with an average particle size of from 1 to 10 nm, having the same chemical composition, a different average particle size and a different emission maximum wavelength in the emission spectra, wherein a standard deviation of emission intensity in each of the at least three kinds of fluorescent semiconductor microparticles is not more than ...

Analytical method and analytical apparatus

Patent Number: 8110406
Publication Date: 2012-02-07
Inventors: Tamiya, Eiichi; Nagatani, Naoki; Yui, Teruko; Endou, Tatsurou; Tanaka, Ryou

[PROBLEMS] To reduce the amount of, for example, a capturing antibody to be employed without lowering detection sensitivity. At the same time, to enable the achievement of intense color development or light emission in a determination area even in the case where only a small amount of a labeled antibody is accumulated. To lower the detection limit in the sandwich method. To enlarge the dynamic range in the competition method. [MEANS FOR SOLVING PROBLEMS] A method of analyzing a test ...

Fluorescent nanoscopy method

Patent Number: 8110405
Publication Date: 2012-02-07
Inventors: Klimov, Andrey Alexeevich; Klimov, Dmitry Andreevich; Klimov, Evgeniy Andreevich; Klimova, Tatiana Vitalyevna

An analysis of an object dyed with fluorescent coloring agents carried out with the aid of a fluorescent microscope which is modified for improved resolving power and called a nanoscope. The method is carried out with a microscope having an optical system for visualizing and projecting a sample image to a video camera which records and digitizes images of individual fluorescence molecules and nanoparticles at a low noise, a computer for recording and processing images, a sample holder ...

Luminescent lanthanide binding chelates

Patent Number: 8110404
Publication Date: 2012-02-07
Inventors: Selvin, Paul R.; Ge, Pinghua

Lanthanide chelates derived from diazacrown ethers having two ethyliminodiacetic acid side chains have increased ability to bind lanthanide ...

Immunoassay method

Patent Number: 8110403
Publication Date: 2012-02-07
Inventors: Matsuno, Tadahiro; Nakamura, Kentaro

It is an object of the present invention to provide an immunoassay method which is capable of simultaneous quantification of a plurality of test substances under a same analysis condition, through adjustment of the measurement sensitivity/range by simply varying the size of particles for use as labels, without changing the spectra of these particles. The present invention provides an immunoassay method which comprises: simultaneously or step-by step developing respective of the plurality of ...

Metal abstraction peptide (MAP) tag and associated methods

Patent Number: 8110402
Publication Date: 2012-02-07
Inventors: Laurence, Jennifer Ann Stowell; Vartia, Anthony Andrew; Krause, Mary Elizabeth

Compositions comprising a tripeptide having the sequence XC₁C₂; wherein X is any amino acid such that XC₁C₂is capable of binding a metal in a square planar orientation or square pyramidal orientation or both; and wherein C₁and C₂are the same or different; and wherein C₁and C₂individually are chosen from a cysteine and a cysteine-like nonnatural amino acid, as well as metal-XC₁C_{2 ...}

Blend dyes and method of identifying leaks

Patent Number: 8110401
Publication Date: 2012-02-07
Inventor: Duerr, John

A blended dye for use in a coolant. In one embodiment of the invention, the blended dye includes a first water miscible dye adapted to fluoresce when illuminated with a light. The first dye preferably has a wavelength of about 340 nm to about 420 nm. The blended dye also includes a second water miscible dye adapted to fluoresce when illuminated with a light having a wavelength of about 400 nm to about 460 nm. The second dye has a different composition from the first ...

Integration of fluids and reagents into self-contained cartridges containing sensor elements

Patent Number: 8105849
Publication Date: 2012-01-31
Inventors: Ballard, Karri L.; Shear, Jason; McDevitt, John T.; Anslyn, Eric; Christodoulides, Nick J.; Floriano, Pierre N.; Neikirk, Dean

Described herein is an analyte detection device and method related to a portable instrument suitable for point-of-care analyses. In some embodiments, a portable instrument may include a disposable cartridge, an optical detector, a sample collection device and/or sample reservoir, reagent delivery systems, fluid delivery systems, one or more channels, and/or waste reservoirs. Use of a portable instrument may reduce the hazard to an operator by reducing an operator's contact with a sample for ...

Programmable electromagnetic array for molecule transport

Patent Number: 8105848
Publication Date: 2012-01-31
Inventors: Su, Xing; Wang, Liming; Yamakawa, Mineo; Schwartz, Kenneth; Schwartz, David

An embodiment of the invention relates to a device comprising (1) an array of electromagnetic elements comprising coils, metal cores, and metal core heads, and (2) a controller that is adapted to control a current for one or more coils individually, to vary the current for said one or more coils individually, to reverse the current for one or more coils individually, and to generate a specific magnetic flux distribution and gradient across two or more coils; wherein the metal core head is ...

Nano-sized optical fluorescence labels and uses thereof

Patent Number: 8105847
Publication Date: 2012-01-31
Inventors: Zheng, Jie; Dickson, Robert Martin

A composition is disclosed which is capable of being used for detection, comprising an encapsulated noble metal nanocluster. Methods for preparing the encapsulated noble metal nanoclusters, and methods of using the encapsulated noble metal nanoclusters are also disclosed. The noble metal nanoclusters are preferably encapsulated by a dendrimer or a peptide. The encapsulated noble metal nanoclusters have a characteristic spectral emission, wherein said spectral emission is varied by ...

Methods using pores

Patent Number: 8105846
Publication Date: 2012-01-31
Inventors: Astier, Yann; Bayley, Hagan; Braha, Orit

The invention relates to a method of identifying an individual nucleotide, comprising (a) contacting the nucleotide with a transmembrane protein pore so that the nucleotide interacts with the pore and (b) measuring the current passing through the pore during the interaction and thereby determining the identity of the nucleotide. The invention also relates to a method of sequencing nucleic acid sequences and kits related ...

System and method for carrying out multiple binding reactions in an array format

Patent Number: 8105845
Publication Date: 2012-01-31
Inventors: Boaz, Ran; Herschhorn, Alon; Levie, Yaakov; Lipson, Doron; Notcovich, Ariel; Lipson, Ariel; Nimri, Shai; Barich, John

A method for determining one or more kinetic parameters of binding between a first binding member and a second binding member. The method comprises adsorbing the first binding member to a surface at a plurality of microspots. The second binding member is then presented to the first binding member at each of the microspots, there being a plurality of combinations of first binding member surface density and second binding member concentration among the plurality of microspots. Data indicative ...

Apparatus and method of using porous material for antigen separation, identification, and quantification with electrophoresis techniques

Patent Number: 8105844
Publication Date: 2012-01-31
Inventors: Sun, Zhen Hong; Pan, Tao; Wang, Wendy; Liu, Xuanbin

An apparatus includes a porous membrane for retaining antigens from a sample as the sample passes through the membrane. The apparatus also includes a first binding region within the membrane. The first binding region includes antibodies associated with a first antigen of interest. At least some of the antigens retained in the membrane are brought into contact with the first binding region by applying an electrophoresis field across the membrane. The porous membrane could also include an ...

Methods and devices to enhance sensitivity and evaluate sample adequacy and reagent reactivity in rapid lateral flow immunoassays

Patent Number: 8105843
Publication Date: 2012-01-31
Inventor: Buchanan, Thomas M.

Methods and devices for rapid lateral flow immunoassays to detect specific antibodies within a liquid sample while also validating the adequacy of the liquid sample for the presence of immunoglobulin and the integrity and immunoreactivity of the test reagents that detect the antibodies of interest, without requiring instrumentation. The methods and devices provide for delivery of a diluted liquid sample to a single location that simultaneously directs the liquid flow along two or more ...

Interleukin-13 as a cardiovascular disease marker

Patent Number: 8105842
Publication Date: 2012-01-31
Inventors: Izuhara, Kenji; Node, Koichi; Hirase, Tetsuaki; Nishimura, Yuki

The present invention relates to use of interleukin-13 as a cardiovascular disease marker. The therapeutic composition and diagnostic composition of the invention for cardiovascular diseases are characterized by comprising an antibody to an interleukin-13 receptor and/or an antibody to ...

Method and assembly for determining the temperature of a test sensor

Patent Number: 8105841
Publication Date: 2012-01-31
Inventors: Peteu, Serban F.; Ripley, Paul; Parasnis, Narasinha C.; Gofman, Igor; Harrison, Bern; Blais, Jeffrey D.; Sun, Steve; Nguyen, Tony; Wang, Xin

An assembly determines an analyte concentration in a sample of body fluid. The assembly includes a test sensor having a fluid-receiving area for receiving a sample of body fluid, where the fluid-receiving area contains a reagent that produces a measurable reaction with an analyte in the sample. The assembly also includes a meter having a port or opening configured to receive the test sensor; a measurement system configured to determine a measurement of the reaction between the reagent and ...

Urine pretreatment agent for urinary protein quantitation, urine pretreatment method, and urinary protein quantitation method

Patent Number: 8105840
Publication Date: 2012-01-31
Inventors: Hara, Masanori; Ogasawara, Shinya; Saito, Akihiko; Hirayama, Yoshiaki; Kurosawa, Hiroyuki

Described are a urine pretreatment agent, a urine pretreatment method, and a urinary protein quantitation method which reduce or cancel the influences of urine pH variations, cancel the influences of precipitates of urinary inorganic salts, and solubilize membrane proteins. The urine pretreatment agent for urinary protein quantitation, includes a buffer, a chelating agent, and a surfactant; the urine pretreatment method includes a step of mixing 10 to 1000 parts by mass of the urine ...

Diagnostic kit for Alzheimer"s disease, diagnostic marker, and detection method for indicator of pathological state thereof

Patent Number: 8105839
Publication Date: 2012-01-31
Inventors: Urakami, Katsuya; Kimura, Miyako

While the differential diagnosis of Alzheimer's disease as distinguished from other types of dementia and the diagnosis of Alzheimer's disease at an early stage where neuronal apoptosis has not proceeded yet are important for the treatment of Alzheimer's disease, it is difficult to differentially diagnose Alzheimer's disease at early stage via a diagnosis mainly made by questioning by a doctor or a diagnostic technique using phosphorylated tau or amyloid β-protein as an indicator. ...

Generation and use of a catalog of polypeptide-related information for chemical analyses

Patent Number: 8105838
Publication Date: 2012-01-31
Inventors: Geromanos, Scott; Silva, Jeffrey Cruz; Gorenstein, Marc V.; Li, Guo-Zhong

A method (100) for performing chemical analyses includes digesting a reference sample to obtain precursors associated with a peptide in the sample (110), separating the precursors to determine values associated with retention times of the separated precursors (120), ionizing the separated precursors to form precursor ions (130), mass analyzing the precursor ions to determine values associated with mass and with ion intensity (140), and storing a

Method for automatic assay of anionic detergents in seawater

Patent Number: 8105837
Publication Date: 2012-01-31
Inventors: Zhang, Xinshen; Jiang, Xiaoping

A method for assaying anionic detergents in seawater comprises: (1) flow a sample through a sample system and an analysis-detection system; flow a reference solution through a reference system, a valve, and the analysis-detection system; where the sample and reference are mixed; and flow the mixture into an optical cell to produce a baseline, (2) flow a sample through the sample system and analysis-detection system; flow a buffer through a buffer system and a color developing system; where ...

Integration of fluids and reagents into self-contained cartridges containing sensor elements and reagent delivery systems

Patent Number: 8101431
Publication Date: 2012-01-24
Inventors: Ballard, Karri L.; Shear, Jason; McDevitt, John T.; Anslyn, Eric; Christodoulides, Nick J.; Floriano, Pierre N.; Neikirk, Dean

Fluorescent sensor based on two fluorescent moieties one of which is a semiconductor nanocrystal and methods of using and making

Patent Number: 8101430
Publication Date: 2012-01-24
Inventors: Nocera, Daniel G.; Bawendi, Moungi G.; Snee, Preston T.; Somers, Rebecca C.

Binding an analyte can cause a change in fluorescence emission of a sensor. The change in fluorescence can be related to the amount of analyte present. The sensor can include a semiconductor nanocrystal linked to a fluorescent moiety. Upon excitation, the fluorescent moiety can transfer energy to the semiconductor nanocrystal, or vice ...

Native analyte as a reference in lateral flow assays

Patent Number: 8101429
Publication Date: 2012-01-24
Inventors: Ledden, David J.; Krauth, Gary H.

This invention is directed to a lateral flow assay for detecting the presence of an analyte in a liquid test sample. The lateral flow assay represents an improvement in the ability to accurately and with high fidelity to detect the presence or absence of a target analyte in a liquid sample, in part, by encompassing a reference region of immobilized, non-diffusible analyte that allows for detection of any factors that interfere with the interaction and binding of the analyte to the labeled ...

Microfluidic systems and control methods

Patent Number: 8101428
Publication Date: 2012-01-24
Inventors: Young, Lincoln C.; Zhou, Peng

The systems and methods disclosed herein include a microfluidic system, comprising a pneumatic manifold having a plurality of apertures, and a chip manifold having channels disposed therein for routing pneumatic signals from respective ones of the apertures to a plurality of valves in a microfluidic chip, wherein the channels route the pneumatic signals in accordance with a configuration of the plurality of valves in the microfluidic ...

Methods for detecting vitamin D metabolites by mass spectrometry

Patent Number: 8101427
Publication Date: 2012-01-24
Inventors: Lee, Kwang-Ja; Holmquist, Brett; Clarke, Nigel; Reitz, Richard E.

Provided are methods of detecting the presence or amount of a vitamin D metabolite in a sample using mass spectrometry. The methods generally comprise ionizing a vitamin D metabolite in a sample and detecting the amount of the ion to determine the presence or amount of the vitamin D metabolite in the sample. Also provided are methods to detect the presence or amount of two or more vitamin D metabolites in a single ...

System and method for the measurement of multiple fluorescence emissions in a flow cytometry system

Patent Number: 8101426
Publication Date: 2012-01-24
Inventors: Hatcher, Jeremy; Durack, Gary

A system and method for the measurement of multiple fluorescence emissions in a flow cytometry system is disclosed where each excitation light source is modulated with a different frequency. A single detector is used to collect the fluorescent emissions excited by all light sources, and the emissions are segregated using Fourier Transform techniques. Systems and methods for the correction of inter-beam coincidence are also ...

Particles embedded in a porous substrate for removing target analyte from a sample

Patent Number: 8101425
Publication Date: 2012-01-24
Inventor: Carbonell, Ruben G.

The invention provides devices, test kits and methods for removing target agents from a sample. The device contains one or more porous matrices having pore sizes larger than 10 μm, and a plurality of particles impregnated therein. The target agents attach the device and are removed from the ...

Bioassays using plasmonic scattering from noble metal nanostructures

Patent Number: 8101424
Publication Date: 2012-01-24
Inventor: Geddes, Chris D.

The present invention relates to detecting and/or measuring scattering effects due to the aggregating metallic nanostructures or the interaction of plasmonic emissions from approaching metallic nanoparticles. The scattering effects may be measured at different angles, different wavelengths, changes in absorption and/or changes in polarization relative to changes in the distances between ...

Label-free high-throughput optical technique for detecting biomolecular interactions

Patent Number: 8101423
Publication Date: 2012-01-24
Inventors: Pepper, Jane; Lin, Bo; Cunningham, Brian T.; Li, Peter

Methods and compositions are provided for detecting biomolecular interactions. The use of labels is not required and the methods can be performed in a high-throughput manner. The invention also provides optical devices useful as narrow band ...

Multidimensional chromatography apparatus and method

Patent Number: 8101422
Publication Date: 2012-01-24
Inventors: Srinivasan, Kannan; Lin, Rong

An ion chromatography apparatus comprising: (a) a first chromatography column, (b) a second chromatography column, the volume of the second column being no greater than 0.9 times the volume of the first; and (c) valving disposed between said first and second columns permitting selective transfer of separated ionic species from first chamber to second chamber for further ...

Volumetric induction phase shift detection system for determining tissue water content properties

Patent Number: 8101421
Publication Date: 2012-01-24
Inventors: Gonzalez, Cesar A.; Rubinsky, Boris

A method of determining the condition of a bulk tissue sample, by: positioning a bulk tissue sample between a pair of induction coils (or antennae); passing a spectrum of alternating current (or voltage) through a first of the induction coils (or antennae); measuring spectrum of alternating current (or voltage) produced in the second of the induction coils (or antennae); and comparing the phase shift between the spectrum of alternating currents (or voltages) in the first and second ...

Carbon measurement in aqueous samples using oxidation at elevated temperatures and pressures

Patent Number: 8101420
Publication Date: 2012-01-24
Inventors: Francis, Gordon K.; Conway, Gregory B.; Huang, Pei; Melanson, Paul; Scaer, Michael R.

Apparatus and methods for measuring the concentrations of organic and inorganic carbon, or of other materials, in aqueous samples are described, together with related, specially adapted components and sub-assemblies and related control, operational and monitoring ...

Carbon measurement in aqueous samples using oxidation at elevated temperatures and pressures

Patent Number: 8101419
Publication Date: 2012-01-24
Inventors: Francis, Gordon K.; Conway, Gregory B.; Huang, Pei; Melanson, Paul; Scaer, Michael R.

Carbon measurement in aqueous samples using oxidation at elevated temperatures and pressures

Patent Number: 8101418
Publication Date: 2012-01-24
Inventors: Francis, Gordon K.; Conway, Gregory B.; Huang, Pei; Melanson, Paul; Scaer, Michael R.

Carbon measurement in aqueous samples using oxidation at elevated temperatures and pressures

Patent Number: 8101417
Publication Date: 2012-01-24
Inventors: Francis, Gordon K.; Conway, Gregory B.; Huang, Pei; Melanson, Paul; Scaer, Michael R.

Compositions for detection and analysis of polynucleotides using light harvesting multichromophores

Patent Number: 8101416
Publication Date: 2012-01-24
Inventors: Gaylord, Brent S.; Bazan, Guillermo C.

Methods, compositions and articles of manufacture for assaying a sample for a target polynucleotide are provided. A sample suspected of containing the target polynucleotide is contacted with a polycationic multichromophore and a sensor PNA complementary to the target polynucleotide. A signaling chromophore absorbs energy from the excited multichromophore and emits light in the presence of the target polynucleotide. The methods can be used in multiplex form. Kits having reagents for ...

Calibration system for use with lateral flow assay test strips

Patent Number: 8101415
Publication Date: 2012-01-24
Inventor: Irvin, Benjamin R.

A method of adjusting a final signal value measured on a lateral flow assay test strip, by: identifying a pre-determined calibration method for the test strip, wherein the pre-determined calibration method corresponds to the manufacturing lot from which the test strip has been made; measuring signal values while performing a lateral flow assay reaction on a test strip; determining a final signal value; and adjusting the final signal value based upon the identified pre-selected calibration ...

Reagent for sample analysis, reagent kit for sample analysis and method for sample analysis

Patent Number: 8101414
Publication Date: 2012-01-24
Inventors: Mizukami, Toshihiro; Narikawa, Tatsuya; Takeshita, Hiroki

A reagent for measuring a basophil and/or a nucleated red blood cell is described. The reagent comprises (a) an alcohol having 4 to 8 total carbon atoms, and (b) one or more fluorescent dyes selected from the group consisting of a compound of the general formula (I) and a compound of the general formula ...

Auto-calibration circuit for analyte measurement

Patent Number: 8101413
Publication Date: 2012-01-24
Inventor: Cheal, Stephen P.

Embodiments provide expanded ability to communicate calibration information to diagnostic systems for determining a characteristic of a test sample. An example system for determining a characteristic of a test sample includes: a test sensor for receiving a test sample; a sensor meter responsive to the test sensor, the sensor meter determining a characteristic of the test sample received on the test sensor; and a calibration element including electrical contacts readable by the sensor meter. ...

System and method for the separation of analytes

Patent Number: 8097472
Publication Date: 2012-01-17
Inventors: Schneider, Thomas Wayne; Baraniuk, James N.

A separation module operates to fractionate or separate an analyte into fractions according to pI, i.e., pI bands, utilizing capillary isoelectric focusing (“CIEF”) within a first microchannel. The fractions are stacked to form plugs, the number of which is determined by a number of parallel second microchannels integrally connected to the first microchannel, into which the fractions are directed according to the buffer characteristics found in each of the individual microchannels. ...

Sample processing devices

Patent Number: 8097471
Publication Date: 2012-01-17
Inventors: Wood, Kenneth B.; Bedingham, William; Aysta, James E.; Robole, Barry W.

Methods and devices for thermal processing of multiple samples at the same time are disclosed. The sample processing devices provide process arrays that include conduits useful in distributing sample materials to a group of process chambers located in fluid communication with the main conduits. The sample processing devices may include one or more of the following features in various combinations: deformable seals, process chambers connected to the main conduit by feeder conduits exiting ...

Microchip analysis method and apparatus

Patent Number: 8097470
Publication Date: 2012-01-17
Inventor: Hanafusa, Nobuhiro

The analysis apparatus for microchips, each at least having a main flow path performing migration of a sample for analysis inside a sheet-like member, comprises a holding part holding microchips so that the multiple main flow paths are provided; a pretreatment part common to the multiple main flow paths for performing a pretreatment step prior to an analysis step in each of the multiple main flow paths; a processing part for performing analysis in each of the main flow paths independently ...

Method and system for determining whether a drug will be effective on a patient with a disease

Patent Number: 8097469
Publication Date: 2012-01-17
Inventors: Röder, Heinrich; Tsypin, Maxim; Grigorieva, Julia

A process of determining whether a patient with a disease or disorder will be responsive to a drug, used to treat the disease or disorder, including obtaining a test spectrum produced by a mass spectrometer from a serum produced from the patient. The test spectrum may be processed to determine a relation to a group of class labeled spectra produced from respective serum from other patients having the or similar clinical stage same disease or disorder and known to have responded or not ...

Using plasma proteomic pattern for diagnosis, classification, prediction of response to therapy and clinical behavior, stratification of therapy, and monitoring disease in hematologic malignancies

Patent Number: 8097468
Publication Date: 2012-01-17
Inventors: Kantarjian, Hagop M.; Keating, Michael J.; Albitar, Maher; Estey, Elihu H.; Giles, Francis J.

The present invention demonstrates that the diagnosis and prediction of clinical behavior in patients with hematologic malignancies, such as leukemia, can be accomplished by analysis of proteins present in a plasma sample. Thus, in particular embodiments the present invention uses plasma to create a diagnostic or prognostic protein profile of a hematologic malignancy comprising collecting plasma samples from a population of patients with hematologic malignancies; generating protein spectra ...

Method for the presumptive detection of substances

Patent Number: 8097467
Publication Date: 2012-01-17
Inventor: Henderson, Jonathan Paul

A composition for use in the detection of an intoxicating drug comprising: (i) a first compound that absorbs UV radiation and generates emitted UV radiation at a wavelength absorbable by said intoxicating drug; and (ii) a second compound that absorbs UV radiation emitted by said intoxicating drug upon absorption by said intoxicating drug of said emitted UV radiation and that emits radiation in the visible spectrum is provided. In addition, methods for detecting an intoxicating drug in a ...

Optical reagent format for small sample volumes

Patent Number: 8097466
Publication Date: 2012-01-17
Inventor: Brenneman, Allen J.

An optical waveguiding optical format enables consistent optical analysis of small sample volumes with minimal variation in light path length among optical formats. The optical format is comprised of an input guide, an output guide, and a sample cavity adapted to allow light to pass through a sample on its way from the input guide to the output guide. A lid removed from the light pathway within the format may be provided with a reagent for assisting fluid ...

Sensor with holographic multiplexed image display

Patent Number: 8097465
Publication Date: 2012-01-17
Inventor: Millington, Roger Bradley

A holographic sensor comprising a thin film polymer matrix that undergoes a change in response to a substance to be sensed, the matrix containing within its volume a set of two or more holographic recordings, each recording providing a holographic image when the sensor is illuminated, wherein the presence or appearance of each image is visible to the eye as a function of the response of the sensor to the substance to be sensed. The images provide the dynamic range of the sensor. Such a ...

Chemical and biological detection arrays

Patent Number: 8097464
Publication Date: 2012-01-17
Inventors: Sydorenko, Oleksandr; Aizenberg, Joanna; Krupenkin, Thomas Nikita; Taylor, Joseph Ashley

Device comprising: a first substrate; a plurality of first raised elements on the first substrate, the first raised elements mutually spaced apart by first channel regions on the first substrate, each of the first raised elements having a first distal end, the first distal ends forming a first array; hydrophobic molecules on the first raised elements; and primary reactive molecules on the first raised elements for generating hydrophilic reaction products. Techniques for utilizing the ...