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Resonant magnetic disks for bioanalyte detection

Patent Number: 8445294
Publication Date: 2013-05-21
Inventor:

Embodiments of the invention relate generally to ferromagnetic microdisks, methods of detecting target bioanalyte using ferromagnetic microdisks, and kits (such as for using in the laboratory setting) containing the reagents necessary to make, and/or use ferromagnetic microdisks for bioanalyte detection, depending on the user's planned application. The methods and products allow the fabrication of ferromagnetic microdisks, and their use in the detection of biological molecules with high ...

Method to increase specificity and/or accuracy of lateral flow immunoassays

Patent Number: 8445293
Publication Date: 2013-05-21
Inventors: ; ; ; ;

The present invention includes methods and devices for preventing interfering substances from affecting the accuracy of a lateral flow immunoassay. In preferred embodiments, a test strip includes a capturing zone that includes at least one mobile capturing reagent that separates at least one interfering substance from the analyte. The capturing zone is preferably located upstream of the sample application zone. In some embodiments, the reagent/conjugate zone is also located upstream of the ...

Compounds and methods for rapid labeling of N-glycans

Patent Number: 8445292
Publication Date: 2013-05-21
Inventor:

The present invention provides compounds and methods for rapid labeling of N-glycans, for example, rapid fluorescent labeling of N-glycans. In one aspect, the present invention provides fluorescent carbamate or thiocarbamate compounds. Upon contacting with N-glycans, the compounds undergo facile reactions with N-glycans to form fluorescent-labeled ...

Method for detecting target substance, and tag, DNA, vector, probe and detection kit for use therewith

Patent Number: 8445291
Publication Date: 2013-05-21
Inventor:

Provide is a method for detecting a target substance, which method can visualize the expression of the target substance at any time point while reducing influences on the functions of the target substance, can use fluorescent dyes having various excitation/emission wavelengths, and can achieve easy staining process. Also provided are a tag, a DNA, a vector, a probe and a detection kit suitable for use in the above-described detection method. Specifically, the method for detecting a target ...

Temperature-adjusted analyte determination for biosensor systems

Patent Number: 8445290
Publication Date: 2013-05-21
Inventors: ;

A biosensor system determines analyte concentration from an output signal generated by an oxidation/reduction reaction of the analyte. The biosensor system adjusts a correlation for determining analyte concentrations from output signals at one temperature to determining analyte concentrations from output signals at other temperatures. The temperature-adjusted correlation between analyte concentrations and output signals at a reference temperature may be used to determine analyte ...

System and method for alkylation process analysis

Patent Number: 8445289
Publication Date: 2013-05-21
Inventors: ; ;

A method and apparatus is provided for determining concentration of components in a liquid hydrocarbon mixture including hydrocarbons and water flowing through an alkylation process. A fluid flow path conveys the liquid continuously from the alkylation process through a first instrument configured for measuring a property of the liquid mixture, and having responsivities to concentration of the components, which are independent of the concentration of the water. A temperature detector ...

Solid-phase detection of terminal monosaccharides cleaved from glycosylated substrates

Patent Number: 8445288
Publication Date: 2013-05-21
Inventors: ; ;

The present invention relates to a novel method for analysing carbohydrates. The invention is in particular useful in detecting a terminal monosaccharide which may be released from a glycosylated substrate for example using an exoglucosidase. After relase from the glycosylated substrate the terminal monosaccharide may be captured on a solid support, incubated with a boronate detection agent and detected by aid of the boronate detection agent. The methods of the invention are useful for a ...

Method and apparatus for determining anticoagulant therapy factors

Patent Number: 8445287
Publication Date: 2013-05-21
Inventors: ;

Methods and apparatus are disclosed for determining new anticoagulant therapy factors for monitoring oral anticoagulant therapy to help prevent excessive bleeding or deleterious blood clots that might otherwise occur before, during or after surgery. The inventive methods and apparatus provide an International Normalization Ratio (INR) based on a coagulation reaction with a blood sample of a living being. Embodiments include methods and apparatus for determining an anticoagulant therapy ...

Flow cell for a flow cytometer system

Patent Number: 8445286
Publication Date: 2013-05-21
Inventors: ;

The flow cytometer system of the preferred embodiment includes a flow cell body that functions to contain, protect, and align the components of the flow cytometer system; a flow channel, coupled to the flow cell body, that functions to conduct and focus sample fluid through an interrogation zone; and a sample injection probe, removably coupled to the flow cell body, that functions to provide a uniform flow of sample fluid to the flow channel. The flow cytometer system is preferably designed ...

Liquid for ejection and method for ejecting bio-specimen

Patent Number: 8445285
Publication Date: 2013-05-21
Inventors: ;

A liquid for ejection includes a bio-specimen, and at least one kind of first compounds expressed by Formula (1),

wherein, in Formula (1), m≧8, and ...

Fixative and staining solutions

Patent Number: 8445284
Publication Date: 2013-05-21
Inventors: ;

The formulations, systems, and methods disclosed herein permit automated preparation of specimens (e.g., biological specimens) for examination. The formulations can include a cytological fixative solution including Azure B, a surfactant, methanol, and ethylene glycol. The disclosed formulations, systems, and methods provide fast, efficient, and highly uniform specimen processing using minimal quantities of fluids. The methods include at least a fixing phase for fixing a specimen to a ...

Multiple-specimen device testing with particle measurement

Patent Number: 8444935
Publication Date: 2013-05-21
Inventors: ;

A sample testing system includes a plurality of sample tubes, each sample tube coupled to a pumping chamber, a pressure control subsystem and a flow control subsystem. The pressure control system includes a first dynamic pump equipped to induce pulsatile pressure in a mass of pumping fluid coupled to the pumping chambers. The flow control subsystem includes a mean flow pump equipped to generate a flow of sample fluid in a plurality of flow loops. Each of the flow loops conducts the flow of ...

D-dimer, troponin, and NT-proBNP for pulmonary embolism

Patent Number: 8444932
Publication Date: 2013-05-21
Inventors: ;

The present invention relates to a method of diagnosing acute pulmonary embolism (PE) in a subject including a) determining the amount of fibrin-fibrinogen degradation products, in particular D-dimer in a sample of the subject; b) determining the amount of a natriuretic peptide in a sample of the subject; c) determining the amount of a cardiac troponin in a sample of the subject; and d) comparing the amounts determined in steps a) to c) to reference amounts, thereby establishing the ...

Fabrication process of a biosensor on a semiconductor substrate

Patent Number: 8440470
Publication Date: 2013-05-14
Inventors: ; ; ;

The disclosure relates to a fabrication process of a biosensor on a semiconductor wafer, comprising steps of: making a central photosensitive zone comprising at least one pixel-type biological analysis device comprising a photosensitive layer, and a first peripheral zone surrounding the central photosensitive zone, comprising electronic circuits. The first peripheral zone is covered by a hydrophilic coating, and the central photosensitive zone is covered with a hydrophobic coating. A ...

System and method for increasing spectroscopic signal

Patent Number: 8440469
Publication Date: 2013-05-14
Inventors: ; ; ;

A method for increasing a spectroscopic signal in a biological assay is provided. The method includes forming a suspension of magnetically attractable particles. The method also includes introducing a first magnetic field at a first location to draw the magnetically attractable particles towards the first location and form a first agglomeration. The method also includes removing the first magnetic field. The method further includes introducing a second magnetic field at a second location to ...

Method for amplifying variation of frequency of signal in piezoelectrical biosensor

Patent Number: 8440468
Publication Date: 2013-05-14
Inventors: ;

Provided is a method for amplifying a frequency variation of a detected signal in a biosensor that is used for detecting a biomolecule by measuring a change in frequency of an oscillating signal, the change being caused by pressure a biomolecule applies to a piezoelectric substance. The method for amplifying a frequency variation of a detected signal comprises the steps of: (a) applying a sample to a probe being fixed to an upper portion of a substrate of the biosensor to allow a ...

Electronic switching, memory, and sensor devices from a discontinuous graphene and/or graphite carbon layer on dielectric materials

Patent Number: 8440467
Publication Date: 2013-05-14
Inventors: ; ;

Electronic devices comprising a dielectric material, at least one carbon sheet, and two electrode terminals are described herein. The devices exhibit non-linear current-versus-voltage response over a voltage sweep range in various embodiments. Uses of the electronic devices as two-terminal memory devices, logic units, and sensors are disclosed. Processes for making the electronic devices are disclosed. Methods for using the electronic devices in analytical methods are ...

Nitrogen oxide analyzer and method for setting parameter applied to nitrogen oxide analyzer

Patent Number: 8440466
Publication Date: 2013-05-14
Inventor:

The nitrogen oxide analyzer obtains the ozone concentration-luminescence response characteristics that show the relationship between the ozone concentration and the light intensity by chemiluminescent response obtained by varying the ozone concentration alone in a steady state, and sets the relationship of the parameter that determines an average period of the sample gas passing the reactor so that the luminescence response is generated in the reactor alone even though the ozone ...

Methods and apparatus for fractionation-based chemical analyses

Patent Number: 8440465
Publication Date: 2013-05-14
Inventors: ; ; ;

A method for analyzing chemicals includes fractionating a complex sample into at least two sample portions that each include portions of two polypeptides though in different concentration ratios, digesting and performing LC/MS on each of the sample portions, and associating precursor ions observed via LC/MS with their corresponding polypeptide in response to LC/MS-provided intensity data. A set of precursor-ions that has substantially similar intensity ratios in both sample portions is ...

Method for evaluation or selection of adiponectin secretion regulator

Patent Number: 8440464
Publication Date: 2013-05-14
Inventor:

Provided is a method for conveniently and rapidly evaluating or selecting an adiponectin secretion regulator.

The method for evaluating or selecting an adiponectin secretion regulator includes the following steps (A) to (C): (A) a step of administering a test substance to an experimental animal; (B) a step of inducing a sleep deprivation in the experimental animal; and (C) a step of measuring blood adiponectin level of the animal, and evaluating change of the blood adiponectin ...

Predicting renal failure in diabetes patients based on placental growth factor and soluble FLT-1

Patent Number: 8440463
Publication Date: 2013-05-14
Inventors: ; ;

Disclosed is a method for predicting the risk of developing renal failure or mortality for a subject suffering from diabetes mellitus. More specifically, a method is disclosed for predicting the risk of developing renal failure for a subject suffering from diabetes mellitus, the method including the steps of determining the amounts of PLGF and sFlt-1 in a sample of a subject suffering from diabetes mellitus and comparing the amounts of PLGF and sFlt-1 determined with reference amounts of ...

Sensing device and method using photo-induced charge movements

Patent Number: 8440145
Publication Date: 2013-05-14
Inventors: ;

A device and method which comprises a sensing surface on a membrane, solid surface or electrode, where the sensing surface contains a dye or chromophore chosen in relation to a particular target substance to be detected and quantified. The dye or chromophore is of a type which produces an electrical signal upon illumination. The particular dye or chromophore chosen for a particular target substance is one in which the presence of the target substance causes a change in the electrical signal ...

Methods and compositions for the production of monoclonal antibodies

Patent Number: 8435801
Publication Date: 2013-05-07
Inventors: ;

The present invention comprises compositions and methods for making monoclonal antibodies. The present invention further comprises vectors that replicate the immune system components, particularly an antigen-presenting cell (APC) element of the immune synapse. Additionally, the present invention may further comprise synthetic ...

Activated labeling reagents and methods for preparing and using the same

Patent Number: 8435800
Publication Date: 2013-05-07
Inventor:

The present invention relates in general to labeling reagents useful for labeling biomolecules. In particular, the invention provides activated labeling reagents having the formula L-Ph, wherein L is an activated labeling molecule and Ph is a phenol. The invention further provides methods of preparing the labeling reagents, methods of using the labeling reagents for synthesizing a labeled biomolecule, kits that include reagents for labeling a biomolecule and kits containing labeled ...

Evaluating heparin preparations for pharmaceutical use

Patent Number: 8435799
Publication Date: 2013-05-07
Inventors: ; ; ; ;

The disclosure features methods of analyzing preparations of heparin, and materials derived from heparin using strong anion exchange high performance liquid chromatography ...

Applications and methods of operating a three-dimensional nano-electro-mechanical resonator and related devices

Patent Number: 8435798
Publication Date: 2013-05-07
Inventors: ; ;

Carbon nanofiber resonator devices, methods for use, and applications of said devices are disclosed. Carbon nanofiber resonator devices can be utilized in or as high Q resonators. Resonant frequency of these devices is a function of configuration of various conducting components within these devices. Such devices can find use, for example, in filtering and chemical ...

Electroluminescent diode sensor

Patent Number: 8435797
Publication Date: 2013-05-07
Inventor:

A senor uses a transduction mechanism of attenuating electroluminescence. Luminescence from a light emitting diode is attenuated as a consequence of direct interaction of an analyte and a electroluminescent material, An electroluminescent diode sensor (EDS) is fabricated in a way that allows the electroluminescent material in the diode to be exposed to gaseous, liquid or solid sample(s) which may affect the luminescence intensity of the ...

Use of a fabric comprising a specific material for detecting the presence of a chemical substance

Patent Number: 8435796
Publication Date: 2013-05-07
Inventors: ; ;

A method for using of a fabric comprising a material chosen from metals, metallic alloys, polymers, inorganic compounds and mixtures thereof, which material is capable of detecting the presence of a chemical substance, for the detection of said chemical ...

Evaluating heparin preparations

Patent Number: 8435795
Publication Date: 2013-05-07
Inventors: ; ; ;

Methods of evaluating heparin preparations, e.g., for suitability for use as a drug or for use in making a drug, by determining the absence, presence or amount of a structural signature that is indicative of the methods used to make the heparin ...

Colorimetric test for antimalarial artemesin derivatives

Patent Number: 8435794
Publication Date: 2013-05-07
Inventor:

A process for testing a composition as containing an artemisinin derivative is provided that includes contacting the composition with a reagent made up of a hydrogen bonding polar organic solvent and an acid having a pK value of less than 3.8 at 25° Celsius and capable of acid catalyzing a decomposition reaction of the artemisinin derivative so as to provide a reaction mixture. The reaction mixture is allowed sufficient time at a reaction temperature for the artemisinin derivative to ...

Method for collecting metal

Patent Number: 8435793
Publication Date: 2013-05-07
Inventor:

It is an object of the present invention to collect a scarce metal such as iridium from a light-emitting element which is no longer used. A method for collecting a metal is provided in which an organic metal compound which can emit visible light from a triplet excited state at room temperature is heated, or an EL layer of a light-emitting layer containing an organic metal compound which can emit visible light from a triplet excited state at room temperature is dissolved in a solvent to form ...

Methods and compositions for treating bleeding disorders

Patent Number: 8435792
Publication Date: 2013-05-07
Inventor:

Aspects of the invention include methods for enhancing blood coagulation in a subject. In practicing methods according to certain embodiments, an amount of a non-anticoagulant sulfated polysaccharide (NASP) is administered to a subject to enhance blood coagulation in the subject. Also provided are methods for preparing a NASP composition having blood coagulation enhancing activity. Compositions and kits for practicing methods of the invention are also ...

System and method for pipetting of fluids, method for calibrating the system

Patent Number: 8435464
Publication Date: 2013-05-07
Inventor:

A system and a method for the automated pipetting of fluids are disclosed as well as a method for calibrating the system. A channel pump having at least one tip-sided port connected to a pipetting tip by a tip-sided pump conduit for generating a positive or negative pressure in the pipetting tip, and at least one reservoir-sided port connected to a system fluid reservoir by a reservoir-sided pump conduit is provided. The channel pump when operated at a nominal flow rate exhibits a fluid ...

Analytical devices with integrated desiccant

Patent Number: 8435461
Publication Date: 2013-05-07
Inventors: ;

An analytical device for performing an assay to determine the presence or approximate quantity of at least one analyte in a liquid sample is described. The device is manufactured to include an integrated desiccant within at least a test strip of the device. Addition of an integrated desiccant within the device improves signal to noise ratio, eases the manufacturing process, and saves in cost of production of the ...

Reactive heterocycle-substituted 7-hydroxycoumarins and their conjugates

Patent Number: 8431416
Publication Date: 2013-04-30
Inventors: ; ; ;

Chemically-reactive, water-soluble, heterocycle-substituted 7-hydroxycoumarin dyes, their bioconjugates and uses are described. The conjugates derived from reactive heterocycle-substituted 7-hydroxycoumarin dyes are used for analyzing biological compounds. These heterocycle-substituted 7-hydroxycoumarin dyes are particularly useful as fluorescent labels for biopolymer detection reagents, such as antibodies or nucleic acid probes. The dye-antibody conjugates of the invention are particularly ...

Immunoassay using insoluble carrier particles and reagent therefor

Patent Number: 8431415
Publication Date: 2013-04-30
Inventor:

The present invention provides a reagent for an immunoassay comprising insoluble carrier particles which can give the values to be determined with high accuracy and reliability, and can be stored for a long time; an immunoassay using the reagent; and a method for keeping the reagent stable. The present invention provides an immunoassay which comprises carrying out an antigen-antibody reaction using insoluble carrier particles in an aqueous medium comprising a buffer having its buffer ...

Methods and compositions for directed microwave chemistry

Patent Number: 8431414
Publication Date: 2013-04-30
Inventor:

The present invention concerns a novel means by which chemical preparations can be made. Reactions can be accelerated on special cartridges using microwave energy. The chips contain materials that efficiently absorb microwave energy causing chemical reaction rate increases. The invention is important in many chemical transformations including those used in protein chemistry, in nucleic acid chemistry, in analytical chemistry, and in the polymerase chain ...

Fluid processing and control

Patent Number: 8431413
Publication Date: 2013-04-30
Inventors: ;

A fluid control and processing system for controlling fluid flow among a plurality of chambers comprises a body including a fluid processing region continuously coupled fluidicly with a fluid displacement region. The fluid displacement region is depressurizable to draw fluid into the fluid displacement region and pressurizable to expel fluid from the fluid displacement region. The body includes at least one external port. The fluid processing region is fluidicly coupled with the at least ...

Microflow analytical system

Patent Number: 8431412
Publication Date: 2013-04-30
Inventor:

A microflow analytical system includes a laminate pump assembly connectable with one or more sources of fluid, one or more pneumatic control pumps, a mixer, and a sensor. The laminate pump assembly is adapted to deliver predetermined volumes of the fluid(s) through a plurality of flow paths which are formed within layers of the assembly. Each flow path can include an inlet valve, a pump valve, and an outlet valve each of which are controllable by the pneumatic control pumps. A series of ...

Methods for detecting vitamin D metabolites by mass spectrometry

Patent Number: 8431411
Publication Date: 2013-04-30
Inventors: ; ; ;

Provided are methods of detecting the presence or amount of a vitamin D metabolite in a sample using mass spectrometry. The methods generally comprise ionizing a vitamin D metabolite in a sample and detecting the amount of the ion to determine the presence or amount of the vitamin D metabolite in the sample. Also provided are methods to detect the presence or amount of two or more vitamin D metabolites in a single ...

Amine--oxide redox indicators for fluorimetric determination of analytes

Patent Number: 8431410
Publication Date: 2013-04-30
Inventors: ; ;

A reagent for detecting an analyte by a redox reaction and a fluorimetric determination is disclosed. The reagent comprises a compound of formula (I):

wherein R¹and R²are each independently selected from R, (CH₂CH₂O)_mR, COR, COOR, and OCOR; each R³is independently selected from NO₂, CN, R, OR, OCOR, COOR, SR, and halogen; R is H or C₁-C₄alkyl, ...

Device and methods of detection of airborne agents

Patent Number: 8431409
Publication Date: 2013-04-30
Inventors: ;

Provided are methods, devices and systems that utilize free-surface fluidics and SERS for analyte detection with high sensitivity and specificity. The molecules can be airborne agents, including but not limited to explosives, narcotics, hazardous chemicals, or other chemical species. The free-surface fluidic architecture is created using an open microchannel, and exhibits a large surface to volume ratio. The free-surface fluidic interface can filter interferent molecules, while ...

Handheld diabetes managing device with light pipe for enhanced illumination

Patent Number: 8431408
Publication Date: 2013-04-30
Inventors: ;

A handheld diabetes management device for providing enhanced illumination includes a housing with an access port and a light aperture. The housing further includes a coupling member on an inner surface thereof. Furthermore, the device includes a measurement engine housed within the housing and communicating with the access port for analyzing body fluid disposed on a dosing area of a diabetes test element. Also, the device includes a circuit board communicating with the measurement engine. ...

Temperature/irradiation/polymerization indicators

Patent Number: 8431407
Publication Date: 2013-04-30
Inventor:

Temperature and/or irradiation and/or polymerization indicators comprise at least one 1,3-dipole and at least one dipolarophile, the dipole preferably being an ylide from the group of azomethines (sydnones), azomethinylides (munchnones), carbonylylides (isomunchnones), thiocarbonylylides (thioisomunchnones), or ...

Terpyridine-substituted compounds and related selective detection methods

Patent Number: 8431406
Publication Date: 2013-04-30
Inventor:

Terpyridine-substituted compounds, compositions and/or related methods, as can be used to selectively detect a wide range of ...

Hyperglycosylated hCG detection device

Patent Number: 8431405
Publication Date: 2013-04-30
Inventors: ;

The present invention related to a pregnancy test device that can selectively detect hyperglycosylated human chorionic gonadotropin (hCG-H) in a liquid sample. The sample can be deposited on a proximal portion of the device for transport to a distal portion of the device. The device can include a release medium formed of a first material and including a detectable label thereon and a capture medium, including a capture site, in fluid communication with the release medium and formed of a ...

Apparatus for transfer of liquid for processing samples

Patent Number: 8431404
Publication Date: 2013-04-30
Inventors: ;

An apparatus for transfer of a liquid using a diaphragm that separates a working fluid volume from a working air volume and can controllably induce a change pressure to draw or expel a target fluid into a tube. The apparatus is particularly suitable for automated processing of nucleic acids and other samples includes a disposable container comprising a tray and a flexible barrier. The barrier is configured to seal with a top edge of the tray, providing a closed, aseptic work area within the ...

Method for detecting analytes

Patent Number: 8431403
Publication Date: 2013-04-30
Inventor:

Provided is method for detecting an analyte, wherein the analyte is labelled with one or more labels relatable to the analyte which are suitable for optical detection, which method comprises: a) applying an oscillating voltage having a first frequency across the labelled analyte and simultaneously performing an optical detection method on the labelled analyte to obtain data from the one or more labels; b) applying an oscillating voltage having a second frequency across the labelled analyte ...

Microfluidic device for counting biological particles

Patent Number: 8431090
Publication Date: 2013-04-30
Inventors: ;

A particle counter for analyzing blood has features which provide for automatic operation and preferably, also provide for portable use in a low resource setting. In a preferred embodiment, preferred embodiment, the device is used to obtain CD4 counts for AIDS ...