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Gene encoding chondroitinase ABC and uses therefor

Patent Number: RE43166
Publication Date: 2012-02-07
Inventors: Oda, Hiroshi; Sato, Nobuyuki; Shimada, Masahiko

Nucleic acid sequences coding for the chondroitinase ABC gene and isolated chondroitinase ABE protein produced in a host cell transformed with a nucleic acid vector directing the expression of a nucleotide sequence coding for chondroitinase ABE protein described. Chondroitinase ABC prepared by chemical synthesis also described. Monoclonal and polyclonal antibodies which are specifically reactive with chondroitinase ABC protein are disclosed. The isolated chondroitinase ABC can be used in ...

Immunoregulator

Patent Number: RE43140
Publication Date: 2012-01-24
Inventors: Benner, Robbert; Khan, Nisar Ahmed

The invention relates to the field of immunology, more specifically to the field of immune-mediated disorders such as allergies, auto-immune disease, transplantation-related disease or inflammatory disease. The invention provides among others an immunoregulator (NMPF), use of an NMPF in preparing a pharmaceutical composition for treating an immune-mediated disorder, a pharmaceutical composition and a method for treating an immune-mediated ...

Apparatus and method for trapping bead based reagents within microfluidic analysis systems

Patent Number: RE43122
Publication Date: 2012-01-24
Inventors: Harrison, D. Jed; Oleschuk, Richard; Lockyear, Loranelle L.; Skinner, Cameron; Li, Paul

The present invention provides an on-chip packed reactor bed design that allows for an effective exchange of packing materials such as beads at a miniaturized level. The present invention extends the function of microfluidic analysis systems to new applications including on-chip solid phase extraction (SPE) and on-chip capillary electrochromatography (CEC). The design can be further extended to include integrated packed bed immuno- or enzyme ...

Process for the manufacture of fused piperazin-2-one derivatives

Patent Number: RE43115
Publication Date: 2012-01-17
Inventors: Linz, Guenter; Duran, Adil

Disclosed are processes for the preparation of fused piperazin-2-one derivatives of general formula (I)

wherein the groups R¹to R⁵, A₁and A₂have the meanings given in the claims and in the description, particularly the preparation of 7,8-dihydro-5H-pteridin-6-one derivatives and intermediates ...

Phase-shifting masks with sub-wavelength diffractive optical elements

Patent Number: 8112726
Publication Date: 2012-02-07
Inventors: Singh, Vivek; Borodovsky, Yan; Hu, Bin

The present invention discloses a method of designing a set of two tiled masks, as well as, a mask including: a first tile, the first tile being transparent to a light, the first tile having a first characteristic linear dimension that is 15% or less of a wavelength of the light; a second tile, the second tile being transparent to the light, the second tile having a second characteristic linear dimension that is 15% or less of the wavelength of the light; and a third tile, the third tile ...

Method for the removal of acetylenes from olefins using ionic liquid-based solution

Patent Number: 8110716
Publication Date: 2012-02-07
Inventors: Ahn, Byoung Sung; Lee, Hyun Joo; Kim, Jin Hyung; Lee, Jung Min; Kim, Hoon Sik

The present invention relates to a process for removing acetylenes from olefins by using an ionic liquid-based solution, and particularly to a process for removing a small amount of acetylenes contained in olefins by using an ionic liquid-based solution where copper halide (CuX, X=halogen atom) is dissolved. In an ionic liquid-based solution used in the present invention, copper halide (CuX) is stabilized by ionic liquid, thus preventing monovalent copper ion (Cu⁺) from being ...

Alkylaromatic production process

Patent Number: 8110715
Publication Date: 2012-02-07
Inventors: Vincent, Matthew J.; Lo, Frederick Y.; Clark, Michael C.; Elia, Christine N.

The present disclosure provides a process for selectively producing a desired monoalkylated aromatic compound comprising the step of contacting in a reaction zone an alkylatable aromatic compound with an alkylating agent in the presence of catalyst comprising a porous crystalline material under at least partial liquid phase conditions, said catalyst manufactured from extrudate to comprise catalytic particulate material of from about 125 microns to about 790 microns in size, having an ...

Polyacene compound and organic semiconductor thin film

Patent Number: 8110714
Publication Date: 2012-02-07
Inventors: Nagata, Kazuto; Naruta, Yoshinori; Yakiyama, Masatoshi

The present invention provides an organic semiconductor material which exhibits a high mobility, and excellent solubility in solvents and oxidation resistance. The present invention also provides an organic semiconductor thin film exhibiting a high mobility, and an organic semiconductor device exhibiting excellent electronic characteristics. A transistor structure is formed by coating the silicon substrate with a thin film of pentacene compound substituted halogens at 6 and 13 positions and ...

Process for producing pentafluoroethane

Patent Number: 8110713
Publication Date: 2012-02-07
Inventors: Perdrieux, Sylvain; Boussand, Béatrice

The present invention relates to a process for producing pentafluoroethane. More particularly, the subject of the invention is a continuous process for producing pentafluoroethane comprising (i) a step of fluorinating perchloroethylene (PER) with hydrofluoric acid, in the gas phase, in the presence of a catalyst, (ii) a step of separating the products issuing from step (i) in order to give a fraction of light products and a fraction of heavy products, comprising hydrofluoric acid, unreacted ...

Process for the preparation of alkylene glycol

Patent Number: 8110712
Publication Date: 2012-02-07
Inventors: Stichter, Hendrik; Smaardijk, Abraham Adriaan; Van Kruchten, Eugene Marie Godfried Andre

The invention provides a process for the preparation of an alkylene glycol from an alkylene oxide. Alkylene oxide reacts with carbon dioxide in the presence of a carboxylation catalyst to provide alkylene carbonate; alkylene carbonate reacts with water in the presence of a hydrolysis catalyst to provide alkylene glycol. An initial charge of the carboxylation catalyst and an initial charge of the hydrolysis catalyst are added, the degradation and activity of the hydrolysis catalyst are ...

Processes for production of 2-bromo-2,2-difluoroethanol and 2-(alkylcarbonyloxy)-1,1-difluoroethanesulfonic acid salt

Patent Number: 8110711
Publication Date: 2012-02-07
Inventors: Jodry, Jonathan Joachim; Fujiwara, Masaki; Narizuka, Satoru; Hagiwara, Yuji; Nagamori, Masashi

Disclosed is a process for producing 2-bromo-2,2-difluoroethanol, which comprises reducing a bromodifluoroacetic acid derivative represented by the formula [1] by using an ate hydride complex as a reducing agent. 2-Bromo-2,2-difluoroethanol thus produced can be used as the starting material to carry out the esterification step, the sulfination step and the oxidation step in this order, thereby producing a 2-alkylcarbonyloxy-1,1-difluoroethanesulfonic acid salt, wherein A represents a ...

Process for producing bis-alkoxylated diols of bisphenol a from spent polycarbonate discs(PC) or PC waste

Patent Number: 8110710
Publication Date: 2012-02-07
Inventors: Liao, Wei-Zhi; Lin, Chao-Hsing; Dai, Shenghong A.; Lin, Hsing-Yo

This invention provides one-pot reaction for digesting polycarbonate waste with alkylene glycol in the presence of a basic catalyst at 180° C. under normal atmospheric pressure. The digested product mixture was found to consist of bisphenol A (BPA) and monoalkoxylated and bisalkoxylated diols of BPA. Alkoxylation of BPA and monoalkoxylated diols of BPA is performed by adding urea or urea derivative (or carbonic acid ester or amine ester) to the digested product mixture at a high ...

Stabilization of hydroformylation catalysts based on phosphoramide ligands

Patent Number: 8110709
Publication Date: 2012-02-07
Inventors: Mackewitz, Thomas; Ahlers, Wolfgang; Volland, Martin; Papp, Rainer; Paciello, Rocco

The present invention relates to a process for the hydroformylation of ethylenically unsaturated compounds by reaction with carbon monoxide and hydrogen in the presence of a catalytically active fluid which comprises a dissolved metal complex of a metal of transition group VIII of the Periodic Table of the Elements with at least one phosphoramidite compound as ligand, wherein the fluid is brought into contact with a ...

Synthesizing and utilizing novel ruthenium nanoparticle-activated charcoal-nano-zinc oxide composite catalyst

Patent Number: 8110708
Publication Date: 2012-02-07
Inventors: Akhmedov, Vagif Melik; Mostafa, Mohamed Mokhtar Mohamed; Al-Rabiah, Abdulrahman A; Bagabas, Abdulaziz A

Ruthenium/activated charcoal (Ru/AC) treated with synthesized nano-ZnO (n-ZnO) is used for the first time as a novel composite catalyst in one-step self-condensation of acetone (DMK) to methyl isobutyl ketone in the gas phase. The DMK self-condensation was performed under atmospheric pressure, in a tubular glass fixed-bed microreactor, under DMK and H₂continuous flow at temperature in the range of 523 to 648 K. Addition of n-ZnO to Ru/AC resulted in a pronounced increase in the ...

Surfactant

Patent Number: 8110707
Publication Date: 2012-02-07
Inventors: Uenishi, Katsuya; Iwase, Toshiaki; Kuroiwa, Jun; Yoshida, Masanori; Murayama, Kouei

A fatty acid salt of an alkyl quaternary ammonium is used as a novel surfactant which is a cationic surfactant having high detergency and low foaming ...

Formoterol tartrate process and polymorph

Patent Number: 8110706
Publication Date: 2012-02-07
Inventors: Tanoury, Gerald J.; Senanayake, Chris H.; Kessler, Donald W.

A method of preparation of a highly pure salt of R,R-formoterol L-tartrate is disclosed. The process provides the most thermodynamically stable polymorph by recrystallization of a novel ...

Processes for making hydrazides

Patent Number: 8110705
Publication Date: 2012-02-07
Inventors: Sahli, Ayman; Chiarello, George Anello

A method is disclosed for preparing hydrazides from hydrazine and an acyl chloride which comprises the steps of (a) preparing a stirred substantially uniform slurry comprising hydrazine and an inert solvent at low temperature; and (b) adding an acyl chloride continuously to said slurry. The method avoids or limits production of undesired bis-hydrazide by-products. The method is used to prepare 3-methyl-3-mercaptobutanoic acid hydrazide, a molecule used to link calicheamicin to a monoclonal ...

Process for the production of stable polymers

Patent Number: 8110704
Publication Date: 2012-02-07
Inventors: Bauer, Erika; Penninger, Stefan; Nefzger, Hartmut; Barnes, James Michael; Schultz, Thomas; Lutz, Heinrich; Di Mews, Horst; Gracik, Charles S.

Stable NCO prepolymers are produced from polyisocyanates having a melting point greater than 70° C., preferably, naphthalene diisocyanate, having advantageous physical properties. An important feature of the process of the present invention is the rapid cooling of the prepolymer. The process of the present invention may be carried out on a continuous or batch basis. The prepolymers of the present invention are particularly suitable for the production of cast polyurethane ...

Retinoid derivative and pharmaceutical composition and use thereof

Patent Number: 8110703
Publication Date: 2012-02-07
Inventors: Chen, Feihu; Shi, Jingbo; Wang, Yuan; Li, Jun; Shen, Juan; Ruan, Jingjing; Wu, Fanrong

The invention relates to a retinoid derivative and pharmaceutical composition and use thereof. The compound of the invention is capable of preventing or treating hematological tumors, such as acute leukemia, chronic leukemia, multiple myeloma and lymphoma, solid tumors, such as liver cancer, rectal cancer, mammary cancer and esophagus cancer, and skin disorders, such as psoriasis and ...

Process for the manufacture of substituted 2-cyano cinnamic esters

Patent Number: 8110702
Publication Date: 2012-02-07
Inventors: Karge, Reinhard; Jing, Shuping; Proplesch, Ralf; Huang, Jing

The invention relates to an improved process for the manufacture of substitute 2-cyanocinnamic esters. This novel economical process provides products in high purity and ...

Process for the preparation of functionalised benzocyclobutenes, and application in the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid

Patent Number: 8110701
Publication Date: 2012-02-07
Inventors: Baudoin, Olivier; Audic, Nicolas; Chaumontet, Manon; Peglion, Jean-Louis; Piccardi, Riccardo

Process for the preparation of compounds of formula (IV):

wherein R₁, R₂, R₃and R₄, which may be identical or different, each represent a hydrogen atom, a linear or branched (C₁-C₆)alkyl group, a linear or branched (C₁-C₆)alkoxy group, a fluorine atom, a chlorine atom, a protected amine group, a protected hydroxyl group, an alkoxycarbonyl group in which the ...

Method for producing vinyl esters of carboxylic acids

Patent Number: 8110700
Publication Date: 2012-02-07
Inventors: Roettger, Roderich; Biel, Markus Christian; Staffel, Wolfgang; Kaczmarek, Reinhard

The present invention relates to a process for preparing vinyl carboxylates, wherein a carboxylic acid is reacted with an alkyne compound in the presence of a catalyst which is selected from salts of perrhenic acid at a temperature of =250° C.

The process gives rise to the desired vinyl esters with a high ...

Cobalt-catalyzed asymmetric cyclopropanation of alkenes with α-nitrodiazoacetates

Patent Number: 8110699
Publication Date: 2012-02-07
Inventors: Zhu, Shifa; Zhang, X. Peter

A process for the cyclopropanation of olefins with a metal porphyrin catalyst and an acceptor/acceptor substituted diazo ...

Process for producing diphenyl carbonate

Patent Number: 8110698
Publication Date: 2012-02-07
Inventor: Ryu, J. Yong

Processes for producing diaryl carbonates are disclosed, where such processes may provide for the production of diaryl carbonates from green house gases, such as carbon dioxide. The processes disclosed advantageously integrate diethyl carbonate and diaryl carbonate production, eliminating the need for solvent-based extractive distillation, as is commonly required when producing diaryl carbonates from dimethyl carbonate, providing for the integration of separation equipment and raw material ...

Method for the production of polymerizable silicones

Patent Number: 8110697
Publication Date: 2012-02-07
Inventors: Jandke, Markus; Peschanel, Birgit; Koopmann, Florian

Polymerizable siloxy-substituted silanes are obtained in high yield and purity by adding a substituted alkoxysilane to a mixture of disiloxane, acetic acid, sulfuric acid, and optionally an acidic catalyst, separating a product phase from an acidic phase, adding hexamethyldisilazane to the product phase and filtering off a resulting salt, followed by ...

Cyclic siloxane compound, a material for forming Si-containing film, and its use

Patent Number: 8110696
Publication Date: 2012-02-07
Inventors: Takamori, Mayumi; Hara, Daiji

The present invention has the objects to provide a novel material for forming Si-containing film, especially a material containing a cyclic siloxane compound suitable to a PECVD equipment for low dielectric constant insulating film, and to provide an Si-containing film using the same, and a semiconductor device containing those films. The present invention relates to a material for forming Si-containing film, containing a cyclic siloxane compound represented by the following general formula ...

Compounds and compositions containing silicon and/or other heteroatoms and/or metals and methods of making and using them

Patent Number: 8110695
Publication Date: 2012-02-07
Inventors: Welker, Mark E.; Pidaparthi, Ramakrishna R.

The present invention relates to compounds, intermediates, compositions, and methods of making compounds and intermediates related to the compounds of Formula (I) and/or Formula (II) and/or Formula (III) and/or Formula (IV) and/or Formula (VI) and/or Formula (VII) as disclosed herein wherein the various substituents are as defined in the written ...

Method for manufacturing dialkylaluminum monohalide

Patent Number: 8110694
Publication Date: 2012-02-07
Inventors: Koga, Seijiro; Okutani, Masanori; Takahashi, Hideya; Nishida, Tadao

A method for manufacturing dialkylaluminum monohalide is provided by which dialkylaluminum monohalide substantially including no zinc component after recovering dialkylzinc from a reaction product obtained by a reaction of zinc halide and trialkylaluminum used as raw materials can be efficiently obtained on an industrial scale at a high yield. According to the method for manufacturing dialkylaluminum monohalide of the present invention, zinc halide is reacted with trialkylaluminum to ...

Method and device for dissolving solids in liquids

Patent Number: 8110693
Publication Date: 2012-02-07
Inventor: Albert, Gert

The invention relates to a method and device for dissolving solid bodies with a liquid, in particular for bringing solid bodies of different shapes and sizes, but mainly very course bodies, in contact with liquids, in order to dissolve them by a chemical reaction or dispersion. The device comprises a closed container (1) that is partially filled with the liquid and into which the solid bodies are introduced before being received inside the container (1) into a basket ...

Organic-inorganic hybrid silicates and metal-silicates having an ordered structure

Patent Number: 8110692
Publication Date: 2012-02-07
Inventors: Diaz Morales, Urbano; Carati, Angela; Bellussi, Giuseppe; Rizzo, Caterina; Zanardi, Stefano; Parker, Wallace O'Neil; Millini, Roberto

The present invention relates to new organic-inorganic hybrid silicates and metal-silicates called ECS, characterized by an X-ray powder diffraction pattern with reflections exclusively at angular values higher than 4.0° of 2θ, preferably at angular values higher than 4.7°, and an ordered structure containing structural units having formula (a) wherein R is an organic group: Formula (a) and possibly containing one or more elements T selected from groups III B, IV B, V B and transition ...

Industrial process for the synthesis of 17α-acetoxy-11β-[4-(N,N-dimethyl-amino)-phenyl]-19-norpregna-4,9-diene-3,20-dione and new intermediates of the process

Patent Number: 8110691
Publication Date: 2012-02-07
Inventors: Tuba, Zoltán; Visky, György; Dancsi, Lajosné ; Csörgei, János; Molnár, Csaba; Magyari, Endréné

A new industrial process for the synthesis of solvate-free 17α-acetoxy-11β-[4-(N,N-dimethyl-amino)-phenyl]-19-norpregna-4,9-diene-3,20-dione [CDB-2914] of formula (I)

which is a strong antiprogestogene and antiglucocorticoid agent. The invention also relates to compounds of formula (VII)

and (VIII)

used as intermediates in the ...

Substituted indolocarbazoles

Patent Number: 8110690
Publication Date: 2012-02-07
Inventors: Ong, Beng S; Wu, Yiliang; Qi, Yu; Li, Yuning

A substituted indolocarbazole comprising at least one optionally substituted ...

Benzanilides with insecticidal activity

Patent Number: 8110689
Publication Date: 2012-02-07
Inventors: Shibuya, Katsuhiko; Murata, Tetsuya; Shimojo, Eiichi; Wada, Katsuaki

Benzanilides of the formula:

in which X represents hydrogen, halogen, nitro, C_1-6alkylthio, C_1-6alkylsulfinyl, C_1-6alkylsulfonyl or C_1-6alkylsulfonyloxy; Y represents halogen or C_1-6alkyl; R¹represents C_1-6alkyl, C_1-6alkylthio-C_1-6alkyl, C_1-6alkylsulfinyl-C_1-6alkyl or C_1-6alkylsulfonyl-C_{1-6 ...}

Method for producing indole derivative having piperidine ring

Patent Number: 8110688
Publication Date: 2012-02-07
Inventors: Shimomura, Naoyuki; Ito, Koichi; Kamada, Atsushi; Miyazawa, Mamoru

It is possible to commercially advantageously prepare 1-{1-[2-(7-methoxy-2,2-dimethyl-4-oxochroman-8-y)ethyl]piperidin-4-yl}-N-methyl-1H-indole-6-carboxamide by coupling (7-methoxy-2,2-dimethyl-4-oxochroman-8-yl)acetaldehyde, which is obtained by oxidizing 8-(2-hydroxyethyl)-7-methoxy-2,2-dimethylchroman-4-one, with ...

Bicyclic compounds with kinase inhibitory activity

Patent Number: 8110687
Publication Date: 2012-02-07
Inventors: Rowland, Robyn Scott; Gould, Alexandra E.; LaMarche, Matthew J.; Vos, Tricia J.; Calderwood, Emily F.; Greenspan, Paul D.

The present invention provides novel bicyclic compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various ...

Azoles as malonyl-CoA decarboxylase inhibitors useful as metabolic modulators

Patent Number: 8110686
Publication Date: 2012-02-07
Inventors: Arrhenius, Thomas; Serafimov, Rossy; Nadzan, Alex M.; Dyck, Jason R.; Cheng, Jie Fei; Wilson, Mark E.; Lopaschuk, Gary D.

The present invention relates to methods of treatment of certain metabolic diseases, and to novel compounds and their prodrugs, and/or pharmaceutically acceptable salts, pharmaceutical compositions containing such compounds useful in treating such diseases. In particular, this invention relates to the use of novel compounds and compositions for treatment of cardiovascular diseases, diabetes, cancers, acidosis, and obesity through the inhibition of malonyl-CoA decarboxylase (MCD). These ...

Azafluorene derivative and organic light-emitting device using the derivative

Patent Number: 8110685
Publication Date: 2012-02-07
Inventors: Muratsubaki, Masanori; Kosuge, Tetsuya; Ohrui, Hiroki; Senoo, Akihiro

A novel azafluorene derivative and an organic light-emitting device having the derivative are provided. The organic light-emitting device includes a pair of electrodes composed of an anode and a cathode one of which is a transparent or semi-transparent electrode, and an organic compound layer interposed between the pair of electrodes. The organic compound layer contains the azafluorene derivative represented by the following general formula ...

Diaza-spiro [4.5] decanes useful as pesticides

Patent Number: 8110684
Publication Date: 2012-02-07
Inventors: Cassayre, Jerome; Pitterna, Thomas; Molleyres, Louis-Pierre; Maienfisch, Peter

A method of combating and controlling insects, acarines, nematodes or molluscs which comprises applying to a pest, to a locus of a pest, or to a plant susceptible to attack by a pest an insecticidally, acaricidally, nematicidally or molluscicidally effective amount of a compound of formula (I) wherein Y is a single bond, C═O, C═S or S(O)_mwhere m is 0, 1 or 2; and R¹, R³, R²and R⁸are defined organic, groups, p is 0, 1, 2, 3 or 4 ...

Piperidinyl compounds that selectively bind integrins

Patent Number: 8110683
Publication Date: 2012-02-07
Inventors: Liu, Li; Maryanoff, Bruce E.; De Corte, Bart; Ghosh, Shyamali; Kinney, William A.

The invention is directed to piperidinyl compounds that selectively bind integrin receptors and methods for treating an integrin mediated ...

Preparation and use of compounds as aspartyl protease inhibitors

Patent Number: 8110682
Publication Date: 2012-02-07
Inventors: McKittrick, Brian; Zhu, Zhaoning; Smith, Elizabeth M.; Stamford, Andrew

Disclosed are compounds of the formula I

or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof,

wherein

- A is a bond, —C(O)—, or —C(R^3′)(R^4′)—;
- X is —N(R¹)— or —C(R⁶)(R⁷)—;
- Y is —S(O)₂—, —C(═O)—, —PO(OR⁹) or ...

Compounds for the treatment of spinal muscular atrophy and other uses

Patent Number: 8110681
Publication Date: 2012-02-07
Inventors: McCall, John M.; Johnson, Graham; Heemskerk, Jill; Fairfax, David; Barnes, Keith D.; Johnson, Matthew Robert

Compounds of Formula (I) or (II) useful for the treatment of spinal muscular atrophy or other uses, as well as methods of using such compounds to increase SMN expression, increase EAAT2 expression, or increase the expression of a nucleic acid that encodes a translational stop codon introduced by mutation or ...

Optically active quaternary ammonium salt having axial asymmetry, and method for producing alpha-amino acid and derivative thereof by using the same

Patent Number: 8110680
Publication Date: 2012-02-07
Inventors: Yamamoto, Kenichiro; Maruoka, Keiji; Nishimoto, Yukifumi

The present invention discloses an optically active quarternary ammonium salt having axial asymmetry and a method for producing an α-amino acid and a derivative thereof using the same. The optically active quarternary ammonium salt having axial asymmetry of the present invention is a chiral phase-transfer catalyst that has a simple structure and that can be produced in a smaller number of process steps. The compound of the present invention is very useful as a phase-transfer catalyst in ...

Nanofilm and membrane compositions

Patent Number: 8110679
Publication Date: 2012-02-07
Inventors: Edelstein, Martin S.; Bivin, Donald B.; Merrill, Grant; Joshi, Serena; Micklatcher, Mark; Karpishin, Timothy B.; Smith, Thomas H.; Kriesel, Joshua W.; Whiteford, Jeffery A.; Jonas, Robert T.

Nanofilms useful for filtration are prepared from oriented amphiphilic molecules and oriented macrocyclic modules. The amphiphilic species may be oriented on an interface or surface. The nanofilm may be prepared by depositing or attaching an oriented layer to a substrate. A nanofilm may also be prepared by coupling the oriented macrocyclic modules to provide a ...

Antibiotic-bound poly(caprolactone) polymer

Patent Number: 8110678
Publication Date: 2012-02-07
Inventors: Leslie, Michelle; Turos, Edward

This invention is the design and synthesis of a caprolactone monomer which bears a pendant protected carboxyl group. This monomer has been copolymerized with caprolactone in varying ratios. After polymerization, the protecting group can be removed and an antibiotic can be attached as a new pendant group. The bioactivity of the antibiotic-bound poly(caprolactone) polymer is ...

Microwave-assisted extraction of polysaccharide from

Patent Number: 8110677
Publication Date: 2012-02-07
Inventors: Zhang, Ji; Yao, Jian; Liang, Junyu; Wang, Yunpu; Wang, Junlong; Wu, Yiqian; Zhang, Yanan; Wang, Xiaodong; Xu, Xiaoqing

This invention relates to a method of extracting crude polysaccharide by microwave-assisted from Artemisia sphaerocephala seed de-oiling dregs. In particular, the invention comprising: microwave-assisted extraction, enzymatic hydrolysis, dialysis et. al. It provides a technique whereby the polysaccharide can be extracted effectively, in a relatively short period of time (20-30 min) with respect to conventional extraction methods and allows for an enhanced extraction yield (more than ...

Prodrugs activated by RNA-dependent DNA-polymerases

Patent Number: 8110676
Publication Date: 2012-02-07
Inventors: Quattrone, Alessandro; Bertini, Ivano; Luchinat, Claudio; Calamante, Massimo; Mordini, Alessandro

The invention provides prodrugs activated by RNA-dependent DNA-polymerases, and methods for treating hematological tumors, blood, and blood derivatives from patients affected by retroviral infections by administering the prodrugs. The invention also provides methods for the preparation of pharmaceutical compositions containing the ...

TP expression-inhibiting compound and siRNA sequence thereof

Patent Number: 8110675
Publication Date: 2012-02-07
Inventors: Chen, Lih-Chyang; Chang, Yu-Sun

The present invention discloses a TP expression-inhibiting compound and a TP expression-inhibiting siRNA sequence, wherein a siRNA sequence partially or completely complementary to the sequence of TP is used to inhibit TP expression, whereby is effectively reduced the survival rate of cancer cells in an anoxic ...

Therapeutic compositions

Patent Number: 8110674
Publication Date: 2012-02-07
Inventors: Bumcrot, David; Manoharan, Muthiah

Therapeutic sRNA agents and methods of making and using are ...

Aggregation sensor and solutions and kits comprising the same

Patent Number: 8110673
Publication Date: 2012-02-07
Inventors: Liu, Bin; Bazan, Guillermo C.

This invention relates to an aggregation sensor useful for the detection and analysis of aggregants in a sample, and methods, articles and compositions relating to such a sensor. The sensor comprises first and second optically active units, where energy may be transferred from an excited state of the first optically active unit to the second optically active unit. The second optically active unit is present in a lesser amount, but its relative concentration is increased upon aggregation, ...

Promoter engineering and genetic control

Patent Number: 8110672
Publication Date: 2012-02-07
Inventors: Fischer, Curt; Alper, Hal S.; Nevoigt, Elke; Stephanopoulos, Gregory

The present invention relates to expression cassettes libraries of expression vectors comprising the same, wherein each vector comprises at least one gene of interest and a promoter operatively linked thereto wherein each promoter comprises a nucleic acid, whose sequence is randomly mutated with respect to that of another in the library and cells comprising the same. Methods utilizing either the libraries or cells of this invention, in optimizing gene expression, protein expression, or ...