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INSECTICIDAL (1,3,5)-TRIAZINYL PHENYL HYDRAZONES

Application Number: 20120040837
Publication Date: 2012-02-16
Inventors: Niyaz, Noormohamed M.; Guenthenspberger, Katherine A.; Brown, Annette V.; Nugent, Jaime S.; Hunter, Ricky

(1,3,5)-Triazinyl phenyl hydrazones are effective at controlling ...

Surfactants in Agrochemical Formulations

Application Number: 20120040834
Publication Date: 2012-02-16
Inventors: Blease, Trevor Graham; Lindner, Gregory James; Richards, Lee David

Surfactant compounds which include an amine ended polyalkylene glycol hydrophile linked to C₂₂to C₆₀mainly hydrocarbyl, particularly composite hydrocarbyl, especially derived from a polymerised fatty acid and/or an aralkyl substituted phenol, hydrophobe, are useful in dispersing solids, particularly active agrochemicals, in aqueous media, or as adjuvants in agrochemical formulations, particularly of water soluble non-selective herbicides. In particular the hydrophobe is ...

NOVEL HERBICIDES

Application Number: 20120040826
Publication Date: 2012-02-16
Inventors: Mathews, Christopher John; Smith, Steve; Taylor, John Benjamin; Jeanmart, Stephane André Marie

Bicyclic dione compounds, and derivatives thereof, which are suitable for use as herbicides.

TEMPLATE-SUPPORTED METHOD OF FORMING PATTERNS OF NANOFIBERS IN THE ELECTROSPINNING PROCESS AND USES OF SAID NANOFIBERS

Application Number: 20120040581
Publication Date: 2012-02-16
Inventor: Kim, Gyeong-Man

The invention relates to a method for producing two- and three-dimensionally structured, microporous and nanoporous webs made up of nanofibers in any form with a very high covering or depositing degree of the fibers by means of a predefined conductive mold (template) as a collector and to the use of the webs according to the invention. The three-dimensional structure formation can be influenced in a directed manner by the deposition density of the nanofibers generated by means of an ...

Heterologous Biomass Degrading Enzyme Expression in Thermoanaerobacterium Saccharolyticum

Application Number: 20120040409
Publication Date: 2012-02-16
Inventors: Herring, Chris; Wiswall, Erin; Hau, Heídi; Rice, Chales; Mcbride, John; Shaw. IV, Arhur J.

Thermophilic gram-positive anaerobic host cells, for example Thermoanaerobacterium saccharolyticum (“T sacch”), express heterologous biomass degrading enzymes, such as cellulases, and are able to produce useful fermentation products from cellulose. Useful fermentation products include, for example, ethanol, acetic acid, lactic acid or CO2. In order to provide maximum expression and activity levels, biomass degrading enzymes can be expressed from codon-optimized nucleotide ...

PROCESSING CELLULOSIC BIOMASS

Application Number: 20120040408
Publication Date: 2012-02-16
Inventors: Blaylock, Michael; Decker, Stephen R.; Lee, David; Selig, Michael J.; Brunecky, Roman; Vinzant, Todd; Himmell, Michael E.

Improved systems and methods for reducing costs and increasing yields of cellulosic ethanol are disclosed herein, along with plants genetically transformed for increased biomass, expression of lignocellulolytic enzyme polypeptides, and/or simplification of harvesting and downstream processing. Methods for processing biomass from these transgenic plants that involve less severe and/or less expensive pre-treatment protocols than are typically employed are also ...

CELLOBIOSE 2-EPIMERASE, ITS PREPARATION AND USES

Application Number: 20120040407
Publication Date: 2012-02-16
Inventors: Chaen, Hiroto; Watanabe, Hikaru; Nishimoto, Tomoyuki; Fukuda, Shigeharu; Yagi, Masahiro

The present invention has objects to provide a thermostable cellobiose 2-epimerase, its preparation and uses. The present invention attains the above objects by providing a thermostable cellobiose 2-epimerase, a DNA encoding the enzyme, a recombinant DNA and transformant comprising the DNA, a process for producing the enzyme, and a process for producing isomerized saccharides using the ...

RATIONALLY-DESIGNED MEGANUCLEASES WITH ALTERED SEQUENCE SPECIFICITY AND DNA-BINDING AFFINITY

Application Number: 20120040406
Publication Date: 2012-02-16
Inventors: Jantz, Derek; Smith, James J.; Hellinga, Homme W.

Rationally-designed LAGLIDADG meganucleases and methods of making such meganucleases are provided. In addition, methods are provided for using the meganucleases to generate recombinant cells and organisms having a desired DNA sequence inserted into a limited number of loci within the genome, as well as methods of gene therapy, for treatment of pathogenic infections, and for in vitro applications in diagnostics and ...

RATIONALLY-DESIGNED MEGANUCLEASES WITH ALTERED SEQUENCE SPECIFICITY AND DNA-BINDING AFFINITY

Application Number: 20120040405
Publication Date: 2012-02-16
Inventors: Jantz, Derek; Smith, James J.; Hellinga, Homme W.

THERMAL CYCLING DEVICE

Application Number: 20120040404
Publication Date: 2012-02-16
Inventor: Grover, Joel

Multi-layer devices suitable for thermal cycling processes. The devices are particularly suitable for performing polymerase chain reactions (PCR). One embodiment includes a first conducting layer, a second conducting layer adjacent to the first layer, and a third conducting layer adjacent to the second layer opposite the first layer. Insulating layers are positioned between said three conducting layers. Continuous channels are formed within the layers. The channels can be formed in either the ...

DIGUANYLATE CYCLASE METHOD OF PRODUCING THE SAME AND ITS USE IN THE MANUFACTURE OF CYCLIC-DI-GMP AND ANALOGUES THEREOF

Application Number: 20120040403
Publication Date: 2012-02-16
Inventors: Liang, Zhao-Xun; Rao, Feng

Described is a new stand-alone diguanylate cyclase polypeptide having a GGDEF motif and a mutated I-site that does not bind c-di-GMP. We demonstrate that the production yield of c-di-GMP and analogues was significantly increased by mutation of a conserved residue in the putative regulatory ...

PLASMID SYSTEM FOR MULTIGENE EXPRESSION

Application Number: 20120040402
Publication Date: 2012-02-16
Inventor: Saha, Deba P.

The present invention provides a plasmid system which facilitates the construction of a single amplifiable plasmid that, having the potential to accommodate many independent expression cassettes, has the ability to express multi-subunit complex proteins such as antibodies and ...

Method For Producing Proteins

Application Number: 20120040401
Publication Date: 2012-02-16
Inventors: Ellis, Mark; Newnham, Laura Ellen

The invention relates to a transcriptionally active recombinant linear polynucleotide encoding a multimeric protein comprising in the following order, a first promoter sequence, a first encoding polynucleotide sequence, a bidirectional regulatory sequence, a second encoding polynucleotide sequence and a second promoter sequence, wherein the first and second encoding polynucleotide sequences are in convergent transcriptional orientation, each encoding polynucleotide sequence encodes a component ...

Novel Permanent Human Cell Line

Application Number: 20120040400
Publication Date: 2012-02-16
Inventors: Volpers, Christoph; Schiedner, Gudrun

The present invention relates to a permanent human cell line comprising a nucleic acid sequence for the adenoviral gene functions E1A and E1B and the nucleic acid sequence for the SV40 large T-antigen or the Epstein-Barr virus (EBV) nuclear antigen 1 (EBNA-1). Further, the present invention relates to a method for transient expression of recombinant polypeptides and proteins in said permanent human cell ...

METHOD FOR THE PRODUCTION OF RECOMBINANT POLYOMAVIRAL VECTOR PARTICLES

Application Number: 20120040399
Publication Date: 2012-02-16
Inventor: De Vries, Walter Gerhardus

The present invention relates to improved methods for the production of viral particles, viral vector particles and recombinant proteins. In particular, the invention relates to improved methods for the production of recombinant polyomaviral vector particles and polyomaviral vector production cell lines. More in particular, the invention relates to methods for the production of simian polyomaviral vector particles such as simian virus 40 (SV40) viral vector particles. The invention also relates ...

ENGINEERED CLEAVAGE HALF-DOMAINS

Application Number: 20120040398
Publication Date: 2012-02-16
Inventor: MILLER, Jeffrey C.

Disclosed herein are engineered cleavage half-domains; fusion polypeptides comprising these engineered cleavage half-domains; polynucleotides encoding the engineered cleavage half-domains and fusion proteins; and cells comprising said polynucleotides and/or fusion proteins. Also described are methods of using these polypeptides and polynucleotides, for example for targeted cleavage of a genomic ...

Photo-Crosslinked Nucleic Acid Hydrogels

Application Number: 20120040397
Publication Date: 2012-02-16
Inventors: Luo, Dan; Roh, Young Hoon

Methods and compositions are provided for producing hydrogel nucleic acid structures using photo-crosslinking. Methods of using the photo-crosslinked hydrogels for cell-free protein production, and for encapsulating and delivering compounds, are also ...

METHODS FOR PURIFYING BIO-ORGANIC COMPOUNDS

Application Number: 20120040396
Publication Date: 2012-02-16
Inventors: Tabur, Pinar; Dorin, Glenn

Methods and systems for purifying bio-organic compounds are described. In certain embodiments, the methods comprise the steps of (a) providing a composition or an emulsion comprising a surfactant, host cells, an aqueous medium and a bio-organic compound produced by the host cells, wherein the solubility of the surfactant in the aqueous medium decreases with increasing temperature and wherein the temperature of the composition or emulsion is at least about 1° C. below a phase inversion ...

ENZYME CATALYST IMMOBILIZED ON POROUS FLUOROPOLYMER SUPPORT

Application Number: 20120040395
Publication Date: 2012-02-16
Inventor: Clendennen, Stephanie Kay

Enzyme catalyst immobilized on porous flouropolymer supports. Catalytically active enzymes can be bound to a variety of fluoropolymer supports for use as a reaction catalyst. Moreover, consistently high rate of conversion during catalyst re-use over time is achieved. Furthermore, inactive enzyme catalyst can be stripped from the support and fresh enzyme can be bound to the support to achieve the original conversion rate. The immobilization of catalytic enzymes on porous fluoropolymers is a ...

MICROTUMOURS

Application Number: 20120040394
Publication Date: 2012-02-16
Inventors: Raju, Paul; Cui, Zhanfeng

A method of producing an in vitro microtumour comprising: seeding a colorectal neoplastic cell into a three dimensional scaffold comprising polysaccharide co-polymer; providing said cell with a culture medium that supports the growth thereof; and incubating said cell in said scaffold for a time sufficient for microtumors to form, wherein said polysaccharide copolymer comprises glutaronate and ...

Directed Differentiation of Primate Pluripotent Stem Cells Into Functional Basal Forebrain Cholinergic Neurons (BFCNs) and Medium Spiny Gabaergic Projection Neurons

Application Number: 20120040393
Publication Date: 2012-02-16
Inventors: Zhang, Su-Chun; Liu, Yan; Ma, Lixiang

Methods of efficiently converting primate pluripotent stem cells to GABA neurons or cholinergic neurons, as well as applications thereof, are ...

DOSIMETRY USING SIGMA SINGLET OXYGEN SPECTROSCOPY

Application Number: 20120040392
Publication Date: 2012-02-16
Inventor: Chen, Sung-Wei

A method includes measuring a photoluminescence of sigma singlet state oxygen decaying to triplet state oxygen. A dosage of delta singlet state oxygen is determined based on the ...

Sepsis diagnostic test

Application Number: 20120040391
Publication Date: 2012-02-16
Inventors: Altrichter, Jens; Mitzner, Steffen; Dollmantel, Hans-Joachim; Sulz, Jana

The invention relates to a method for the extracorporeal qualitative or semi-quantitative determination of the amount of indicators for the systemic inflammatory response system (SIRS) or sepsis in the blood, blood serum, blood plasma, other body fluids or lavages or their constituents of human or animal subjects. In order to provide a test which is better than that of the prior art, with which the presence and/or the severity of SIRS or sepsis can be rapidly, economically, reliably and ...

Method for Introducing Protein and/or Peptide Into Cell

Application Number: 20120040390
Publication Date: 2012-02-16
Inventors: Futami, Junichiro; Nakanishi, Hidetaka; Yamada, Hidenori; Kai, Takashi

The present invention provides a method of intracellular introduction by which a protein and/or peptide can be efficiently introduced into living cells and which makes it possible to effectively analyze the behavior and function of the protein and/or peptide introduced and can be suitably utilized/applied, for example in the technology “live cell imaging” which realizes the immunohistochemical visualization in living cells under physiological conditions.

The ...

METHOD FOR DEMONSTRATION OF A MOLECULAR EVENT IN A CELL BY MEANS OF FLUORESCENT MARKER PROTEINS

Application Number: 20120040389
Publication Date: 2012-02-16
Inventors: De Giorgi Ichas, Francesca; Tomasello, Flora; Dessolin, Jean; Ichas, François; Piazza, Pier-Vincenzo; Schembri, Laura; Lartigue, Lydia

The invention relates to a method for demonstration of the occurrence of a molecular event, particularly in a cell, characterised by the detection of the ‘solubilisation’ of a fixed protein marker (or the fixing of a solubilised protein marker) which is a direct or indirect marker for the occurrence of the particular molecular event. Said protein marker is present in the cell before the above detection, the cell being subjected to a permeabilisation of the plasma membrane before detection, ...

CELLULASE-CONTAINING DISH DETERGENTS

Application Number: 20120040388
Publication Date: 2012-02-16
Inventors: Augustinus, Pieter; Bollier, Marc Maurice Pierre; De Nobel, Johannes Gerardus; Johanna, Maria Petra

The present invention provides cellulase-containing dishwashing detergent compositions. The present invention also provides methods for the production of and use of such detergents. In addition, a spaghetti mix soil suitable for testing dishwashing detergents is also ...

METHOD AND REAGENT FOR MEASURING MEVALONIC ACID, 3-HYDROXYMETHYLGLUTARYL COENZYME A, AND COENZYME A

Application Number: 20120040387
Publication Date: 2012-02-16
Inventor: Matsuoka, Takeshi

The present invention provides a method for measuring the concentration of an analyte in a test solution wherein the analyte is mevalonic acid and/or 3-hydroxymethylglutaryl coenzyme A, comprising the following steps (p) and (q): (p) a step of allowing an enzyme that catalyzes a reaction represented by Reaction Formula 1 and an enzyme that catalyzes a reaction represented by Reaction Formula 2 to act on a test solution containing mevalonic acid and/or 3-hydroxymethylglutaryl coenzyme A in the ...

FINE-GRAINED FILLER SUBSTANCES FOR PHOTOMETRIC REACTION FILMS

Application Number: 20120040386
Publication Date: 2012-02-16
Inventors: Petrich, Wolfgang; Hiller, Bernd; Knappe, Wolfgang-Reinhold; Zimmer, Volker; Lehr, Ursula; Bedon-Gomez, Luis David

There is proposed a diagnostic test element for detecting an analyte in a sample of a body fluid, more particularly in whole blood. The diagnostic test element comprises at least one test field having at least one detection reagent, wherein the detection reagent is set up to pass through at least one detectable change in the presence of the analyte, more particularly an optical change. The test field has at least one detection layer which comprises the detection reagent and which comprises ...

COAGULOGEN RAW MATERIAL, PROCESS FOR PRODUCING THE SAME, AND METHOD AND APPARATUS FOR MEASURING PHYSIOLOGICALLY ACTIVE SUBSTANCE OF BIOLOGICAL ORIGIN USING THE SAME

Application Number: 20120040385
Publication Date: 2012-02-16
Inventor: Yabusaki, Katsumi

Disclosed is a technique for obtaining a coagulogen raw material which can irreversibly inactivate the activity of a coagulase while retaining the function of coagulogen in an LAL reagent, a LAL reagent contaminated by an organism-derived biologically active substance or the like, and which can be used in a reagent. An LAL reagent is heated at a predetermined temperature for a predetermined period of time to deactivate only the activity of an enzyme contained in the LAL reagent irreversibly, ...

LYOPHILISED DABIGATRAN

Application Number: 20120040384
Publication Date: 2012-02-16
Inventor: Stangier, Joachim

The invention relates to a lyophilised form of dabigatran of formula (I) its use as a calibrator in the assays for the determination of pharmacodinamic effects of dabigatran etexilate as well as such assays per se. In the preparation of the lyophilised standards, dabigatran is dissolved in an aqueous acidic solution before freeze-drying.

Methods and Kits Relating To Metabolite Biomarkers For Colorectal Cancer

Application Number: 20120040383
Publication Date: 2012-02-16
Inventors: Jia, Wei; Qiu, Yunping

Embodiments of the present invention provide methods of assessing metabolite biomarkers to diagnose, monitor, prognose and treat colorectal cancer, as well as kits and systems in use thereof. In some embodiments, the metabolite biomarker profile of an subject suspected of having colorectal cancer may be compared to the metabolite biomarker profile of a healthy subject to determine if there are differences between the profiles indicative of colorectal cancer. In some embodiments, the stage of a ...

METHOD OF DETECTING PROGRESSION OF A NEURODEMENTING DISEASE

Application Number: 20120040382
Publication Date: 2012-02-16
Inventors: DODEL, Richard; BACHER, Michael; PRZYBYLSKI, Michael; STEFANESCU, Raluca; MANEA, Marilena

Isolated, monoclonal, human, anti-β-amyloid antibodies are provided which bind to dimeric forms of Ab with higher affinity than to monomeric forms of Ab and when bound to an Aβ polypeptide comprising Aβ(21-37) shield Aβ(21-37) from proteolytic digestion. The antibodies were shown to inhibit fibril formation and reduce plaque size in vivo and to not bind brain vessel walls. Accordingly, the antibodies are useful in human and veterinary medicine for the treatment and prophylaxis of ...

PREDICTING MORTALITY AND DETECTING SEVERE DISEASE

Application Number: 20120040381
Publication Date: 2012-02-16
Inventors: Snider, James V.; Jacobson, Sven

Measurement of circulating ST2 and/or IL-33 concentrations is useful for the prognostic evaluation of subjects, in particular for the prediction of adverse clinical outcomes, e.g., mortality, and the detection of severe ...

OPTICALLY-DETECTABLE ENZYME SUBSTRATES AND THEIR METHOD OF USE

Application Number: 20120040380
Publication Date: 2012-02-16
Inventors: CORRY, SCHUYLER BOON; DOWNEY, WILLIAM LOUIS; FILANOSKI, BRIAN; GEE, KYLE RICHARD; GREENFIELD, I. LAWRENCE; HIRSCH, JAMES DAVID; JOHNSON, IAIN; RUKAVISHNIKOV, ALEKSEY

The present invention relates to compounds that are substrates for an enzyme, and upon reaction with the enzyme provide a detectable response, such as an optically detectable response. In particular, the compounds have utility in detecting the presence of a β-lactamase in a sample. In addition to the compounds, methods are disclosed for analyzing a sample for the presence of a β-lactmase, for example, as an indicator of expression of a nucleic acid sequence including a sequence coding for a ...

METHODS FOR DIFFERENTIATING PLASMA- DERIVED PROTEIN FROM RECOMBINANT PROTEIN IN A SAMPLE

Application Number: 20120040379
Publication Date: 2012-02-16
Inventors: Weber, Alfred; Turecek, Peter; Schwarz, Hans-Peter

The present invention relates, in general, to methods for detecting and quantitating plasma-derived protein and recombinant protein in a sample based on the difference in protein glycosylation, when the plasma protein and the recombinant protein are essentially the same ...

Meprobromate Immunoassay

Application Number: 20120040378
Publication Date: 2012-02-16
Inventors: Benchikh, Elouard; McConnell, Ivan; Fitzgerald, Peter; Lowry, Philip

Carisoprodol is a centrally-acting prescription drug of known abuse. Upon ingestion it is rapidly metabolised to meprobamate, also a prescription drug with abuse potential. Current immunoassays are specific for carisoprodol and therefore have a short window of detection and, furthermore, are ineffective at detecting meprobamate. The current invention, underpinned by an antibody specific for meprobamate, overcomes these ...

RECOGNITION OF CYP2E1 EPITOPES

Application Number: 20120040377
Publication Date: 2012-02-16
Inventor: Njoku, Dolores Benedicta

A critical epitope of human cytochrome P4502E1 (CYP2E1) associated with the development of hepatic autoimmune disease, including methods and kits for diagnosis and prognosis using the critical epitope as a biomarker for hepatic autoimmune ...

LUNG CANCER DIAGNOSTIC POLYPEPTIDE, METHOD FOR DETECTING LUNG CANCER, AND METHOD FOR EVALUATING THERAPEUTIC EFFECT

Application Number: 20120040376
Publication Date: 2012-02-16
Inventors: Toyama, Atsuhiko; Ueda, Koji; Nakagawa, Hidewaki; Sato, Taka-Aki

A novel biomarker for use in lung cancer diagnosis is ...

ANTI-MUC1 ANTIBODY

Application Number: 20120040375
Publication Date: 2012-02-16
Inventors: Hinou, Hiroshi; Nishimura, Shin-Ichiro; Onoda, Junji; Numata, Yoshito; Naito, Shoichi; Ohyabu, Naoki

An object of the present invention is to provide an antibody which does not bind to a normal cell, and is specific for a cancer cell. The object was solved by the finding by the present inventors that an antibody obtained by immunizing an animal using a 2,3ST glycopeptide as an antigen unexpectedly recognizes a sugar chain specific for a cancer specifically and remarkably, and consequently, can recognize and kill a cancer cell expressing MUC1 having such a cancer cell-specific sugar chain. The ...

METHOD FOR DETECTING RENAL DISEASE COMPRISING MEASURING HUMAN MEGALIN IN URINE

Application Number: 20120040374
Publication Date: 2012-02-16
Inventors: Saito, Akihiko; Tomino, Yasuhiko; Asanuma, Katsuhiko; Ogasawara, Shinya; Kurosawa, Hiroyuki; Hirayama, Yoshiaki

This invention provides a diagnostic kit and a diagnostic marker used for diagnosing a renal disease. This invention also provides a method for detecting a renal disease comprising measuring at least one type of human megalin existing in urine selected from among full-length human megalin and human megalin fragments of (i) to (iii): (i) full-length human megalin; (ii) a human megalin endodomain fragment lacking a human megalin ectodomain; and (iii) a human megalin ectodomain fragment lacking a ...

Integrated Diagnosis of Heparin-Induced Thrombocytopenia

Application Number: 20120040373
Publication Date: 2012-02-16
Inventor: Ubeda, Mariano

Disclosed are methods for the early detection of heparin-induced thrombocytopenia comprising the quantitative detection of chemokine platelet factor-heparin complexes, autoantibodies to such complexes, and platelet activation. Also disclosed are assays to detect the propensity of a subject to develop heparin-induced ...

RECEPTOR TYROSINE KINASE ASSAYS

Application Number: 20120040372
Publication Date: 2012-02-16
Inventors: Olson, Keith R.; Achacoso, Philip; Raab, William; Feng, Wei; Wehrman, Thomas

Methods for detecting phosphorylation of receptor tyrosine kinases (“RTKs”) upon activation and the modulation of activation by a candidate compound are provided. The method employs cells comprising two fusion products: (1) an RTK fused to a small fragment of β-galactosidase and (2) a phosphotyrosine binding peptide fused to the large fragment of β-galactosidase, where the 2 fragments weakly complex to form an active enzyme, and optionally a construct for a cytosolic RTK phosphorylating ...

DIAGNOSIS OF PREECLAMPSIA

Application Number: 20120040371
Publication Date: 2012-02-16
Inventors: Buhimschi, Catalin S.; Buhimschi, Irina; Norwitz, Errol

The present invention provides methods and compositions related to the detection and/or monitoring of the levels of angiogenic factors, specifically VEGF, PlGF and sFlt-1, in urine samples obtained from pregnant women and the effects of such levels on the risk of developing complications of pregnancy, including hypertensive disorders such as preeclampsia, in the first, second, and/or third trimester of pregnancy. The present invention also provides kits for identifying and screening patients at ...

SYSTEMS AND METHODS FOR RAPIDLY CHANGING THE SOLUTION ENVIRONMENT AROUND SENSORS

Application Number: 20120040370
Publication Date: 2012-02-16
Inventors: Chiu, Daniel; Pihl, Johan; Karlsson, Mattias; Orwar, Owe; Sinclair, Jon; Pettersson, Frederik

The invention provides microfluidic systems for altering the solution environment around a nanoscopic or microscopic object, such as a sensor, and methods for using the same. The invention also provides a system and methods for modulating, controlling, preparing, and studying ...

ON-BOARD CONTROL DETECTION

Application Number: 20120040369
Publication Date: 2012-02-16
Inventors: Newman, Peter Michael; Hodges, Alastair M.

Embodiments disclosed herein relate to a sensor comprising an on-board control system and a testing system. The on-board system can determine viability of the control system or the testing system. Also disclosed are methods of using such a ...

MUTATED VOLTAGE-GATED SODIUM CHANNEL NAV ALPHA SUBUNIT FOR IDENTIFICATION OF MODULATORS

Application Number: 20120040368
Publication Date: 2012-02-16
Inventor: Chahine, Mohamed

Reagents, methods and kits for screening for compounds that modulate the activity of voltage-gated sodium channels (NaV), such as human NaV1.5/SC-N5A/hH1 are described. The reagents, methods and kits are based on mutated NaV alpha subunit polyptides of SEQ ID NO:5 with mutations at positions 372, 898, 1419 and 1711 (the DEKA motif) and at positions 11485, 1486 and 1487 (the IFM motif) resulting in increased permeability for a group IIA divalent cation (Ca⁺) and decreased inactivation ...

COMPOSITIONS, METHODS AND USES FOR DISEASE DIAGNOSIS

Application Number: 20120040366
Publication Date: 2012-02-16
Inventors: Holt, Jeffrey; Gibson, Kimberly A.

Embodiments of the present invention generally related to methods and compositions for diagnosing or predicting a genetic disorder. In certain embodiments, the methods may include use of rapid and inexpensive assay systems. Other embodiments concern novel mutation specific peptides associated with BRCA1 or BRCA2. In yet other embodiments, haploid cells are used to diagnose a genetic disorder in a ...

NEW COMPETENCE STIMULATING PEPTIDE

Application Number: 20120040365
Publication Date: 2012-02-16
Inventors: Gardan, Rozenn; Monnet, Véronique

The present invention concerns a new competence stimulating peptide identified in Firmicutes, in particular Streptococcus, and more preferably S. thermophilus and methods of producing transformation competent Firmicutes, in particular Streptococcus, and more preferably S. thermophilus ...

METHOD FOR ENRICHING A PROKARYOTIC DNA

Application Number: 20120040363
Publication Date: 2012-02-16
Inventors: SCHMIDT, Karl-Hermann; STRAUBE, Eberhard; RUSSWURM, Stefan
A method is described for enriching procaryotic DNA, said method including the steps of contacting at least one procaryotic DNA with at least one protein or polypeptide which is capable of specifically binding to non-methylated CpG motifs, and separating the protein/polypeptide-DNA complex. Moreover, the application relates to a kit for carrying out said ...

Multipotent Lymphohematopoietic Progenitor Cells

Application Number: 20120040362
Publication Date: 2012-02-16
Inventors: Slukvin, Igor I.; Thomson, James A.; Vodyanyk, Maksym A.
This invention relates to hematopoietic precursors derived from human embryonic stem cells. In the culture of differentiated cells from human ES cells, the fully committed hematopoietic precursors are CD34+ and CD43+ but not CD45+. If the cells are cultured until they express CD45, then the cells lose the ability to produce differentiated cells of the lymphoid ...