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VARIANT LOVD POLYPEPTIDES AND THEIR USES

Application Number: 20130130351
Publication Date: 2013-05-23
Inventor: Codexis, Inc.,

The present disclosure provides acyltransferases useful for synthesizing therapeutically important statin ...

OBLIGATE HETERODIMER VARIANTS OF FOKI CLEAVAGE DOMAIN

Application Number: 20130130350
Publication Date: 2013-05-23
Inventors: Ramalingam, Sivaprakash; Kandavelou, Karthikeyan; Chandrasegaran, Srinivasan

Disclosed are methods of making and using engineered FokI cleavage domain variants. Also disclosed are methods, compositions and fusion proteins containing obligate heterodimers of engineered FokI cleavage domain variants and DNA binding domains, such as zinc finger protein (ZFP) domains and transcription activator-like effector (TALE) ...

COOPERATIVE AND DYNAMIC ASSEMBLY OF AFFINITY COMPLEXES

Application Number: 20130130349
Publication Date: 2013-05-23
Inventor: Patterson, William

The invention generally relates to the field of immunochemistry including antibody therapy, diagnostics, and basic research and specifically relates to the area of alternatives to natural antibodies including artificial antibodies or antibody mimics. The invention relates particularly to the cooperative assembly of stable affinity ...

Polymers for Functional Particles

Application Number: 20130130348
Publication Date: 2013-05-23
Inventors: The Brigham and Women's Hospital, Inc., ; Massachusetts Institute of Technology,

A method includes producing libraries of nanoparticles having highly controlled properties, which can be formed by mixing together two or more macromolecules in different ratios. One or more of the macromolecules may be a polymeric conjugate of a moiety to a biocompatible polymer. The nanoparticle may contain a drug. The moiety may include a polypeptide or a polynucleotide, such as an aptamer. The moiety may be a targeting moiety, an imaging moiety, a chelating moiety, a charged moiety, or a ...

CONSTRUCTS AND METHODS FOR THE ASSEMBLY OF BIOLOGICAL PATHWAYS

Application Number: 20130130347
Publication Date: 2013-05-23
Inventor: Cornell University,

The present invention is directed to a synthetic nucleic acid scaffold comprising one or more subunits, each subunit comprising two or more different protein-binding sequences coupled together. The present invention further relates to systems and methods for assembling a synthetic biological pathway and producing a biological pathway product or a precursor product using the synthetic nucleic acid ...

Human Waste Treatment System and Method

Application Number: 20130130346
Publication Date: 2013-05-23
Inventors: Hansen, Jaron C.; Hansen, Lee D.

A human waste treatment system is disclosed that includes at least one waste receptacle such as an airline-style toilet, an anaerobic digester such as an induced bed reactor, and a gas conditioner. Human waste may be moved by a macerator pump. Inside the digester, bacteria digests organic solids to form biogas. The anaerobic digester may be operated at thermophilic temperatures to kill pathogenic bacteria in the waste and produce treated water. The gas conditioner purifies the biogas which may ...

PRODUCTION OF RENEWABLE AROMATIC COMPOUNDS

Application Number: 20130130345
Publication Date: 2013-05-23
Inventors: Thai, Wendy; Sikkenga, David A.; Schroeder, Will

The invention provides a process for producing a variety renewable aromatic compounds such as benzene, toluene, xylenes, and cumene, as well as compounds derived from these including, for example, aniline, benzoic acid, cresol, cyclohexane, cyclohexanone, phenol and bisphenol A, toluene di-isocyanate, isophthalic acid, phthalic anhydride, terephthalic acid and dimethyl terephthalate. The invention also provides for renewable forms of these aromatic ...

MICROORGANISM VARIANTS HAVING HYDROCARBON PRODUCING ABILITY AND METHOD FOR PRODUCING HYDROCARBON USING THE SAME

Application Number: 20130130344
Publication Date: 2013-05-23
Inventors: Lee, Sang Yup; Choi, Yong Jun

The present invention relates to a microorganism variant having the ability to produce hydrocarbons, including alkane, and a method of producing hydrocarbons, including alkane, using the same, and more particularly, to a microorganism variant obtained by introducing a gene encoding an enzyme converting fatty acyl-acp to free fatty acid, a gene encoding an enzyme converting free fatty acid to fatty acyl-CoA, a gene encoding an enzyme converting fatty acyl-CoA to fatty aldehyde and a gene ...

PROCESSES AND SYSTEMS FOR DRY-MILLED CORN ETHANOL AND CORN OIL PRODUCTION WITH IMPROVED CARBON FOOTPRINT

Application Number: 20130130343
Publication Date: 2013-05-23
Inventors: PURTLE, Ian; ZULLO, Luca

The present invention improves corn dry milling in several ways. Integrated corn biorefinery processes are disclosed which can produce ethanol, edible corn oil, DDGS, solvent-extracted meal, power, and optionally crude corn oil, starting from corn. Some variations employ corn fractionation and edible corn oil recovery using liquid carbon dioxide, avoiding hazardous hydrocarbon-based solvents to produce edible corn oil. Some variations employ integration of gas-fired co-generation into the ...

Yeast Strain for Production of Four Carbon Alcohols

Application Number: 20130130342
Publication Date: 2013-05-23
Inventor: Butamax(TM) Advanced Biofuels LLC,

Yeast cells with a reduced general control response to amino acid starvation were found to have increased tolerance to butanol in the growth medium. The reduced response was engineered by genetic modification of a gene involved in the response, a GCN gene, to eliminate activity of the encoded protein. Yeast strains with an engineered butanol biosynthetic pathway and a genetic modification in a gene involved in the general control response to amino acid starvation, which have increased butanol ...

ELECTRO-AUTOTROPHIC SYNTHESIS OF HIGHER ALCOHOLS

Application Number: 20130130341
Publication Date: 2013-05-23
Inventors: Cho, Kwang Myung; Liao, James C.

The disclosure provides a process that converts CO₂to higher alcohols (e.g. isobutanol) using electricity as the energy source. This process stores electricity (e.g. from solar energy, nuclear energy, and the like) in liquid fuels that can be used as high octane number gasoline substitutes. Instead of deriving reducing power from photosynthesis, this process derives reducing power from electrically generated mediators, either H₂or formate. H₂can be derived ...

BIOSYNTHESIS OF CAFFEIC ACID AND CAFFEIC ACID DERIVATIVES BY RECOMBINANT MICROORGANISMS

Application Number: 20130130340
Publication Date: 2013-05-23
Inventors: UNVERSITY OF GEORGIA RESEARCH FOUNDATION, INC., ; YAN, Yajun; LIN, Yuheng

Microorganisms are genetically engineered to synthesize caffeic acid from simple carbon sources via a tyrosine intermediate by means of a dual pathway that utilizes both endogenous and engineered enzymatic ...

FERMENTATION PROCESS FOR THE PRODUCTION OF ORGANIC ACIDS

Application Number: 20130130339
Publication Date: 2013-05-23
Inventors: Hermann, Theron; Reinhardt, James; Yu, Xiaohui; Udani, Russell; Staples, Lauren

This invention relates to improvements in the fermentation process used in the production of organic acids from biological feedstock using bacterial catalysts. The improvements in the fermentation process involve providing a fermentation medium comprising an appropriate form of inorganic carbon, an appropriate amount of aeration and a biocatalyst with an enhanced ability to uptake and assimilate the inorganic carbon into the organic acids. This invention also provides, as a part of an ...

NOVEL HYDROLASE PROTEIN

Application Number: 20130130338
Publication Date: 2013-05-23
Inventors: Miyake, Ryoma; Katou, Ryouhei; Kawabata, Hiroshi; Asada, Kuniko

It is an object of the present invention to provide a novel hydrolase, which is used when dialkyl 2-vinylcyclopropane-1,1-dicarboxylate is hydrolyzed with an enzyme, so as to efficiently obtain (1S,2S)-1-alkoxycarbonyl-2-vinylcyclopropanecarboxylic acid that is useful as an intermediate for synthesizing therapeutic agents for hepatitis C. According to the present invention, there is provided a hydrolase protein, which consists of the amino acid sequence shown in any one of SEQ ID NOS. 2 to 5 ...

Enzymatic Acylation Method Using an Acylphosphonate Donor

Application Number: 20130130337
Publication Date: 2013-05-23
Inventors: Martin, Juliette; Wahler, Denis; Guillamot, Gerard; Fourage, Laurent

The invention relates to an enzymatic acylation method including at least the following steps of: contacting at least one compound having at least one function selected from among the amine, alcohol, or thiol functions, at least one microorganism having an acyl transfer activity and/or an acyl transfer enzyme, and at least one acylphosphonate donor of formula (I), where: R is an alkyl, alkene, uikyne, aryl, or aralkyl radical, or is —ORa, —SRa, —NRaRb, where Ra and Rb are identical or ...

CHAIN-SELECTIVE SYNTHESIS OF FUEL COMPONENTS AND CHEMICAL FEEDSTOCKS

Application Number: 20130130336
Publication Date: 2013-05-23
Inventor: Energy & Environmental Research Center Foundation,

A method comprising providing a starting composition comprising a polyunsaturated fatty acid, a polyunsaturated fatty ester, a carboxylate salt of a polyunsaturated fatty acid, a polyunsaturated triglyceride, or a mixture thereof; self-metathesizing the starting composition or cross-metathesizing the starting composition with at least one short-chain olefin in the presence of a metathesis catalyst to form self-/cross-metathesis products comprising: cyclohexadiene; at least one olefin; and one ...

Purification Methods and Systems Related to Renewable Materials and Biofuels Production

Application Number: 20130130335
Publication Date: 2013-05-23
Inventors: Austin, Glen; Bhattacharjee, Binita X.; Borden, Jacob; Carrera, Martin E.; Gokhale, Amit A.; Horler, Chris; Hurley, Aidan; Mack, Eric T.; Bolton, Leslie W.

Methods of producing renewable materials may include consuming a fermentation feedstock with a fermentation organism to produce a renewable material in fermentation broth; water may then be separated from the feedstock or broth using one or more phase separations, or the renewable material may be concentrated from the feedstock or broth using one or more phase separations. Methods of producing biofuel components may include consuming a lignocellulosic or sugar fermentation feedstock with a ...

BIOFUEL AND ELECTRICITY PRODUCING FUEL CELLS AND SYSTEMS AND METHODS RELATED TO SAME

Application Number: 20130130334
Publication Date: 2013-05-23
Inventors: Speers, Allison; Young, Jenna; Reguera, Gemma

A fuel cell comprising an anode electrode, a cathode electrode and a reference electrode electronically connected to each other; a first biocatalyst comprising a consolidated bioprocessing organism (e.g., a cellulomonad or clostridium or related strains, such as Cellulomonas uda (C. uda), C. lentocellum, A. cellolulyticus, C. cellobioparum, alcohol-tolerant C. cellobioparum, alcohol-tolerant C. uda, Clostridium cellobioparum (C. cellobioparum) ...

Processes for Making (R)-Ethyl 4-Cyano-3 Hydroxybutyric Acid

Application Number: 20130130333
Publication Date: 2013-05-23
Inventor: Verenium Corporation,

The invention provides novel processes for making ethyl-4-cyano-3-hydroxybutyrate, e.g., (R)-ethyl 4-cyano-3-hydroxybutyric acid, and 4-cyano-3-hydroxybutyric acid. The invention provides protocols for making and 4-cyano-3-hydroxybutyric acid and ethyl-4-cyano-3-hydroxybutyrate by whole cell processes, cell lysate processes, “one pot processes” and “multi-pot” processes using a variety of ...

NOVEL METHOD FOR PREPARING PTEROCARPAN

Application Number: 20130130332
Publication Date: 2013-05-23
Inventors: Hur, Hor-Gil; Han, Jae Hong; Seo, Ji Young

The present invention relates to a novel method for preparing pterocarpan from isoflavan-4-ol.

With the use of the method of the present invention, the absolute configuration of C3 and C4 positions on the B-ring of isoflavan-4-ols is maintained identically also in pterocarpans, and thus, enantiopure pterocarpans can be efficiently ...

METHOD OF PRODUCING SUGARS USING A COMBINATION OF ACIDS TO SELECTIVELY HYDROLYZE HEMICELLULOSIC AND CELLULOSIC MATERIALS

Application Number: 20130130331
Publication Date: 2013-05-23
Inventors: Ma, Chi-Cheng; Binder, Thomas P.; Doane, Perry H.; Bloom, Paul D.

A method is provided for producing sugars using a combination of acids to hydrolyze hemicellulosic and cellulosic materials in biomass, said combination of acids namely comprising a first, weak organic acid (such as acetic acid or formic acid) for providing a pentose product or stream from hydrolyzing hemicellulosic materials in the biomass on a batchwise, semi-continuous or continuous basis, and a second, strong mineral acid (such as sulfuric acid) for providing a hexose product or stream from ...

NOVEL GLYCOSYL HYDROLASE WITH BETA-XYLOSIDASE AND BETA-GLUCOSIDASE ACTIVITIES AND USES THEREOF

Application Number: 20130130330
Publication Date: 2013-05-23
Inventors: Cheng, Haili; Zhao, Ruiyu; Cheng, Kedi; He, Huixia; Meng, Chao; Zhu, Huixin; Zhu, Ping

A novel glycosyl hydrolase with activities of beta-xylosidase and beta-glucosidase is provided. Said glycosyl hydrolase can convert 7-xylosyltaxane compounds to 7-hydroxyltaxane ...

METHOD FOR EXTRACTING SUBSTANCES FROM SOAPBERRY FRUIT AND ITS SEEDS

Application Number: 20130130329
Publication Date: 2013-05-23
Inventor: Hsu, Heng-Jui

An exclusive method for extracting active interface saponin and organic substances from soapberry; organic elements and oleic alcohol products from soapberry seeds through fermenting process, and end products made therefrom. By this method, every part of the soapberry is processed to become the raw material of varies of products and daily necessaries. Said method is toxin free and biologically safe, produce no solid and liquid wastage, zero carbon emissions, zero chemical pollution, low energy ...

METHOD OF TREATING PLANT BIOMASS

Application Number: 20130130328
Publication Date: 2013-05-23
Inventors: Nakamura, Risa; Katahira, Satoshi; Tabata, Kazuhide; Ishida, Nobuhiro; Takahashi, Yoshina

Plant biomass is immersed in a solution that contains a polar solvent and an imidazolium salt that has a melting point of at least 100° C. As a result, the cellulose and hemicellulose present in the plant biomass are relaxed (decrystallized and depolymerized) and brought into an easy-to-degrade state. Reacting the immersed plant biomass with a cellulase produces saccharide at a high conversion ...

Polypeptides Having Beta-Glucosidase Activity, Beta-Xylosidase Activity, or Beta-Glucosidase and Beta-Xylosidase Activity and Polynucleotides Encoding Same

Application Number: 20130130327
Publication Date: 2013-05-23
Inventors: Novozymes, Inc., ; Novozymes A/S,

The present invention relates to isolated polypeptides having beta-glucosidase activity, beta-xylosidase activity, or beta-glucosidase and beta-xylosidase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the ...

Polypeptides Having Beta-Glucosidase Activity, Beta-Xylosidase Activity, or Beta-Glucosidase and Beta-Xylosidase Activity and Polynucleotides Encoding Same

Application Number: 20130130326
Publication Date: 2013-05-23
Inventors: Novozymes, Inc., ; Novozymes A/S,

Polypeptides Having Beta-Glucosidase Activity, Beta-Xylosidase Activity, or Beta-Glucosidase and Beta-Xylosidase Activity and Polynucleotides Encoding Same

Application Number: 20130130325
Publication Date: 2013-05-23
Inventors: Novozymes, Inc., ; Novozymes A/S,

GENETICALLY ENGINEERED STRAIN WSJ-IA FOR PRODUCING ISOVALERYL SPIRAMYCIN I

Application Number: 20130130324
Publication Date: 2013-05-23
Inventors: Wang, Yiguang; Jiang, Yang; Yang, Shengwu; Zhao, Xiaofeng

A genetically engineered strain WSJ-IA for producing isovaleryl spiramycin I. Also provided is a method for preparing the strain, comprising the steps of: (a) constructing a recombinant plasmid comprising a double gene ist-acyB2; (b) transforming the plasmid into an isovaleryl spiramycin I—producing strain to obtain the strain WSJ-IA. The level of isovaleryl spiramycin I produced by fermentation of the strain WSJ-IA is increased 1.7 times and the fermentation potency thereof increased 4.14 ...

PREVENTION AND ALLEVIATION OF STERIC HINDRANCE DURING SINGLE MOLECULE SYNTHESIS

Application Number: 20130130323
Publication Date: 2013-05-23
Inventors: Ma, Congcong; Wyatt, Paul

The present invention provides compositions and methods for reducing steric hindrance in the product of nucleic acid polymerase reaction. Methods and compositions of the invention encompass application of exonucleases, endonucleases, and uracil-DNA glycosylases to a nucleic acid polymerase reaction such that newly formed nucleic acid strands are modified (e.g., cleaved) while the polymerase reaction continues to ...

Modified RNA Ligase for Efficient 3` Modification of RNA

Application Number: 20130130322
Publication Date: 2013-05-23
Inventor: The Rockefeller University,

The invention provides a novel truncated mutated T4 RNA ligase 2. In addition, methods are provided for ligating pre-adenlylated donor molecules to the 3′ hydroxyl group of RNA in the absence of ATP using the ...

Programmable Oligonucleotide Synthesis

Application Number: 20130130321
Publication Date: 2013-05-23
Inventor: SYNTHETIC GENOMICS, INC.,

The invention relates to methods and devices for preparing synthetic nucleic ...

ENZYMES

Application Number: 20130130320
Publication Date: 2013-05-23
Inventors: Holliger, Philipp; Cozens, Christopher; Pinheiro, Vitor B.

The invention relates to a nucleic acid polymerase capable of producing a non-DNA nucleotide polymer from a DNA nucleotide polymer template, said polymerase comprising amino acid sequence having at least 36% identity to the amino acid sequence of SEQ ID NO:1, wherein said amino acid sequence is mutated relative to the amino acid sequence of SEQ ID NO:1 at one or more residues of the thumb region, said residues selected from: amino acids 651 to 679 (patch 10A); wherein said amino acid sequence ...

CELLS AND METHODS FOR PRODUCING RHAMNOLIPIDS

Application Number: 20130130319
Publication Date: 2013-05-23
Inventors: Stein, Nadine; Schaffer, Steffen; Wessel, Mirja; Thiessenhusen, Anja

The invention relates to cells and nucleic acids and also use thereof for producing rhamnolipids, and also methods for producing ...

PROCESS FOR OBTAINING BIOCHEMICALS IN A ZERO-LIQUID DISCHARGE PLANT

Application Number: 20130130318
Publication Date: 2013-05-23
Inventors: PYLKKANEN, Vesa; NELSON, Kimberly; RETSINA, Theodora

A method is presented for the production of cellulosic ethanol, acetic acid and derivatives from the extract containing fibers and hemicelluloses after steam cooking of biomass in a host plant. The process is integrated with the host plant process to minimize the effect of loss of heat value from the extracted hemicelluloses and eliminate the need for the waste water treatment ...

METHOD FOR PRODUCING SUBSTANCE

Application Number: 20130130317
Publication Date: 2013-05-23
Inventors: Ogawa, Akira; Kurihashi, Wataru; Konno, Yoshinobu

The present invention provides a medium suitable for animal cell culture, a culture method using the same, and the like. The present invention relates to a method for culturing animal cells having an ability to produce a substance, which comprises culturing the animal cells in a medium supplemented with an oligopeptide having one or more L-cysteines and excluding glutathione, a method for producing a substance by culturing animal cells having the ability to produce the substance, which ...

CELL CULTIVATION PROCESS

Application Number: 20130130316
Publication Date: 2013-05-23
Inventors: Joosten, Christoph E.; Leist, Christian; Schmidt, Jörg

This invention relates to a cell culture process for the production of polypeptides in mammalian CHO cells characterized by one or more temperature and pH shifts which are adjusted in respect to their timing and step size to reduce cell death, increase product yield and improve product ...

FUSION PROTEIN

Application Number: 20130130315
Publication Date: 2013-05-23
Inventors: Schönberger, Tanja; Degen, Heidrun; Münch, Götz; Holthoff, Hans-Peter; Bühring, Hans-Jörg; Leder, Christoph; Gawaz, Meinrad; Bültmann, Andreas

An isolated nucleic acid molecule selected from the group consisting of: vi. a nucleic acid molecule comprising a nucleotide sequence which is at least 85% identical to the nucleotide sequence of SEQ ID NO:1 or a complement thereof; vii. a nucleic acid molecule comprising a fragment of at least 1500 consecutive nucleotides of the nucleotide sequence of SEQ ID NO:1, or a complement thereof; viii. a nucleic acid molecule which encodes a polypeptide comprising an amino acid sequence at least 85% ...

Expression of Proteins in Plants

Application Number: 20130130314
Publication Date: 2013-05-23
Inventor: University of Cape Town,

The invention relates to a method of producing an influenza virus H5 polypeptide in a plant comprising the steps of cloning an influenza H5 gene or nucleic acid encoding its functional equivalent into a vector adapted to target components present in the plant, infiltrating at least a portion of the plant with the vector or transforming plant tissue with the vector so as to transiently express the influenza virus H5 polypeptide, and/or to create a transgenic plant; and recover the influenza ...

METHOD OF SYNTHESIZING A SUPPRESSOR tRNA, DNA CONSTRUCT AND USE THEREOF FOR PRODUCING A NON-NATURAL AMINO ACID-INCORPORATED PROTEIN

Application Number: 20130130313
Publication Date: 2013-05-23
Inventors: YOKOYAMA, Shigeyuki; Hino, Nobumasa; Mukai, Takahito; Kobayashi, Takatsugu; Sakamoto, Kensaku

There are provided a DNA construct comprising a suppressor tRNA gene of a non-eukaryote containing no internal promoter functioning in a eukaryotic cell, and a eukaryotic or bacteriophage promoter linked at the 5′ end of the tRNA gene, a method for synthesizing a suppressor tRNA by using the DNA construct, and a process for producing protein incorporating a non-natural amino acid by using the ...

METHODS AND STRAINS FOR THE PRODUCTION OF SARCINAXANTHIN AND DERIVATIVES THEREOF

Application Number: 20130130312
Publication Date: 2013-05-23
Inventors: Netzer, Roman; Brautaset, Trygve; Bruheim, Per

The present invention relates to a new strain of Micrococcus luteus, named Otnes7, which is superior to known strains in its ability to synthesise the carotenoid sarcinaxanthin and a method of producing sarcinaxanthin or a derivative thereof, said method comprising introducing into and expressing in a host cell one or more nucleic acid molecules encoding an activity in the sarcinaxanthin biosynthetic ...

METHODS AND SYSTEMS FOR ASSESSING CLONALITY OF CELL CULTURES

Application Number: 20130130311
Publication Date: 2013-05-23
Inventors: Shapiro, Ehud Y.; Ben-Yehezkel, Tuval

Methods of determining clonality of a cell culture are provided. Also provided are systems employing the above methods in high throughput sample ...

ABSORBENT PAPER AND USE THEREOF FOR BREAST CANCER DETECTION

Application Number: 20130130310
Publication Date: 2013-05-23
Inventor: Atossa Genetics, Inc.,

Biological samples of mammary fluid or components thereof are obtained using a breast pump device coupled with an absorbent paper or membrane, optionally facilitated by administering oxytocin to the subject. The breast pump device stimulates expression of mammary fluid and provides for collection of diagnostic samples on the absorbent paper or membrane to evaluate breast disease, including cancer. The biological sample may include fluid containing one or more of cells or cellular components, ...

Radiopharmaceutical Production System and Quality Control System Utilizing High Performance Liquid Chromatography

Application Number: 20130130309
Publication Date: 2013-05-23
Inventors: Nutt, Ronald; Giamis, Antony M.; McFarland, Aaron

HPLC-based quality control systems to perform quality control testing on a radiopharmaceutical solution shortly after synthesis. An HPLC-based quality control system makes efficient use of sample volume and is compatible with a variety of radioisotopes and radiopharmaceutical compounds. In several embodiments, the automated nature of an HPLC-based quality control system allows for quality control tests to be conducted quickly and with minimal impact on user workflow. When used as part of an ...

PROCESS FOR DIRECTLY MEASURING MULTIPLE BIODEGRADABILITIES

Application Number: 20130130308
Publication Date: 2013-05-23
Inventor: ENVOLURE,

A method for measuring the biodegradability of organic substrates by the fluorescent and/or colorimetric detection of the microbial activity generated by the addition of organic substrates to a mixture of ...

CELL OBSERVATION DEVICE AND CELL OBSERVATION METHOD

Application Number: 20130130307
Publication Date: 2013-05-23
Inventors: Ikeda, Takahiro; Sugiyama, Norikazu; Kataoka, Takuji

A cell observation device is provided with a reflection interference shutter 106A which adjusts a light quantity of light emitted from a reflection interference measurement light source 106, a quantitative phase shutter 105A which adjusts a light quantity of light emitted from a quantitative phase measurement light source, a camera 110 which images reflected light from the reflection interference measurement light source 106 to generate a reflection ...

ZN (II) BASED COLORIMETRIC SENSOR AND PROCESS FOR THE PREPARATION THEREOF

Application Number: 20130130306
Publication Date: 2013-05-23
Inventors: Mahato, Prasenjit; Ghosh, Amrita; Mishra, Sanjiv Kumar; Shrivastava, Anupama; Das, Amitava; Mishra, Sandhya

A colorimetric chemosensor molecule having a aza-macrocycle Zn (II)-complex (L.Zn) (Scheme 1, Formula 1A) which can recognize selectively and efficiently ATP (Adenosine triphosphate), a biologically significant triphosphate in aqueous medium at pH 7.4 is described. Since ATP is the source of energy in living organisms, L.Zn (Scheme 1, Formula 1A) can also be used as a staining agent in the living cells through binding to ATP, generated in situ during the metabolic ...

INDENTIFYING ANTIFUNGAL AGENTS THAT INHIBIT IAA OR A YAP FAMILY

Application Number: 20130130305
Publication Date: 2013-05-23
Inventor: Prusty Rao, Reeta

The present invention relates to methods of screening for antifungal agents by identifying agents that bind to or otherwise inhibit indole-3-acetic acid (IAA) or that bind to or otherwise inhibit the expression or activity of a protein within the Yap family or a gene encoding a protein within the Yap ...

METHODS FOR SCREENING MICROBIAL GROWTH INHIBITION ACTIVITY ON MATERIALS

Application Number: 20130130304
Publication Date: 2013-05-23
Inventor: Saint Louis University, a non-profit organizaton,

Disclosed are methods of determining the effectiveness of an antimicrobial agent in reducing or inhibiting microbial growth on a substrate. The disclosed methods may be used to determine microbial growth at time points subsequent to antimicrobial treatment of the material surface and exposure to microorganisms. The disclosed invention also measures visible microbial growth using a semi-quantitatively method that is more accurate and less subjective than estimates of growth used previously. The ...

METHODS FOR SCREENING MICROBIAL REMEDIATION AGENTS

Application Number: 20130130303
Publication Date: 2013-05-23
Inventor: Saint Louis University, a non-profit organization,

Disclosed are methods for determining the efficacy of antimicrobial agents used in the treatment of building materials after microbial contamination has occurred, for the purpose of killing existing microbial growth and reducing or inhibiting recurrent or subsequent microbial growth. The disclosed methods may be used to determine microbial growth at time points subsequent to antimicrobial treatment of the material surface. The disclosed invention also measures visible microbial growth in a ...

POST PROTEIN HYDROLYSIS REMOVAL OF A POTENT RIBONUCLEASE INHIBITOR AND THE ENZYMATIC CAPTURE OF DNA

Application Number: 20130130302
Publication Date: 2013-05-23
Inventor: University of South Florida,

The present invention concerns compositions and methods of extracting infectious pathogens from a volume of blood. In one embodiment, the method includes the steps of creating a fibrin aggregate confining the pathogens and introducing a fibrin lysis reagent to expose the pathogens for analysis. The present invention also concerns materials and methods for removing aurintricarboxylic acid (ATA) from a ...