If you’re interested more generally in aging-related issues, you might check out Biogerontologi.se. It’s in Swedish (as opposed to Norwegian, which it looks like you are), but my understanding is that the two languages are fairly mutually intelligible.

I also haven’t come across any studies that follow individual gene expression and survival in animals, but I think some similar insights can be gained from aging studies that have intervention and control groups whose gene expression and survival are recorded as they age. The best example I’ve found so far is Scott Pletcher’s 2002 study in Linda Partridge’s lab looking at gene expression changes with age in both control and calorie-restricted flies (Current Biology, 2002, data available at http://www.hcoa.org/scott/). By comparing the control and intervention groups’ profiles with aging, you’re able to at least get some insights into correlations between different genes and longevity and survival. Pletcher made some good progress towards untangling some of this in his paper, and another group from China took a different approach a couple of years ago using Pletcher’s data (Xue 2007 Mol Sys Bio).

I’m a complete newbie here, so I’d be very interested to hear your thoughts on this data, and what other sources of similar data you’ve come across that might be even more useful in answering these kinds of questions. I’ll hopefully be able to track you down and discuss it in person at the Buck symposium in a couple weeks–and I’m very excited about that.

Reviewer IJCNS
(http://www.ijcns.org/)

“… adult muscle stem cells have a receptor called Notch, which triggers growth when activated. Those stem cells also have a receptor for the protein TGF-beta that, when excessively activated, sets off a chain reaction that ultimately inhibits a cell’s ability to divide.

The researchers said that aging in mice is associated in part with the progressive decline of Notch and increased levels of TGF-beta, ultimately blocking the stem cells’ capacity to effectively rebuild the body.

This study revealed that the same pathways are at play in human muscle, but also showed for the first time that mitogen-activated protein (MAP) kinase was an important positive regulator of Notch activity essential for human muscle repair, and that it was rendered inactive in old tissue.”

Let me know what you think.

People who say this always miss the point; just as smokers and drinkers do.

Let me see if I can make this simple as well clear.

You don’t do CL etc, or avoid smoking, liquor and so on, to live an extra 2 years or longer.

You do it so that from 50 to say 90ish + you don’t suffer all the age related deceases, and are strong as you can be to the day your clock stops. If you follow healthy guidelines you can be quite self sufficient in much later years with independence that only younger people for the most part have had; prior to advance research like this showing us new ways to extend a longer healthy life.

So, you and others looks at this from the wrong side of the life cycle. Maybe you should see it from the side that is moving forward rather than the last years.

So we have it clear; again it’s so you have a steady good 50 to 90ish years + of less time in the doctors office or hospital system, not so you gain an extra two years in this realm at the end.

Geez, how hard is this to understand.

Michael Pappas
http://www.pbase.com/Arrfilms

Just in case it wasn’t clear, for those of you who want to help SENS win the money — you have to comment on the contest page. Not here — unless you really just want to comment, in which case, feel free.

“…all of the technologies for extending life span increase health span as well.”

For this reason it is imperative that support for longevity research continues. In concert, however, must be effort to meet the challenge of overpopulation, to which success with longevity will make critical.

(1) International Journal of Computer Science and Information Security (IJCSIS) (http://sites.google.com/site/ijcsis/contact-ijcsis)

(2) International Journal of Computer and Network Security (IJCNS) (http://www.ijcns.org/)