Jackson, who missed the second half of the 2008 season after injuring his right knee during practice, suffered an anterior cruciate ligament injury to his left knee during a non-contact drill Wednesday. He had been rehabbing the knee after he was hurt against Seattle on October 4th.

Sanders, a two-time Pro Bowler, tore his left bicep against the 49ers last weekend and will need surgery.
The shame of it is he had just gotten back in the lineup two weeks ago. He had missed all of training camp and the first five games of the year after undergoing offseason knee surgery. He has missed 40 of 87 games during his injury-plagued, six-year NFL career.

Indianapolis’ other veteran cornerback, Kelvin Hayden, is also expected to be sidelined for the next three to four weeks after he suffered a sprained knee during the 18-14 win over San Francisco. Hayden is not expected to undergo surgery.

“Not real sure (how long Hayden will be out),” coach Jim Caldwell said. “We’re kind of looking at probably a three to four week window.”

Colts safety Bob Sanders has a new injury to add to his growing collection. Sanders, who underwent offseason knee surgery and made his first appearance of the year against the San Francisco 49ers, was sidelined at practice today due to an elbow injury. Also missing time today: defensive end Dwight Freeney (non-injury related, wide receiver Anthony Gonzalez (knee), cornerback Kelvin Hayden (knee), kicker Adam Vinatieri (knee) and cornerback Marlin Jackson (knee).

Second-year linebacker Philip Wheeler and undrafted rookie Ramon Humber are expected to replace Hagler. Indy also will promote rookie linebacker Cody Glenn to the active roster from the practice squad.

Hagler was fourth on the Colts with 36 tackles. Running back Donald Brown (shoulder) and cornerback Marlin Jackson (strained ACL) were expected to practice Wednesday. Caldwell did not say whether they would play against Houston this weekend.

Most folks at first glance, knowing that the San Francisco 49ers were going to visit Lucas Oil Stadium to take on the Indianapolis Colts, probably wrote this game off as another notch in the Colts’ belt. Yet, it didn’t exactly happen like that.

True enough, quarterback Peyton Manning got his numbers, but it took a 22-yard touchdown pass from running back Joseph Addai early in the fourth quarter which allowed Indianapolis to remain undefeated as they edged the San Francisco 49ers 18-14.

And interestingly enough, I am not convinced that the Colts deserved to win this game as their running game was non-existent and even Manning, despite his numbers was not his usual accurate self, at times. It certainly was promising for San Francisco early in the first quarter as Frank Gore broke loose for a 64-yard TD run, giving the 49ers a 7-0 lead.

A 38-yard field goal by Matt Stover would put the Colts to within 7-3 as both teams entered the second quarter. Stover would add another field goal 10 seconds into the period to narrow it further to 7-6; But with 33 ticks left on the clock, 49ers QB Alex Smith connected with tight end Vernon Davis on a 8-yard TD pass, extending San Francisco’s lead to 14-6, yet Manning led a lightning-quick drive which allowed Stover to convert a 31-yard Fg with 1 second left in the half, allowing the Colts to go to their locker room down by only 14-9.

The third quarter was uneventful, with the only scoring being yet another Stover FG which got the Colts to within 2 points at 14-12. The winning score for Indianapolis was of an unconventional nature, courtesy of a 22-yard TD pass from Addai to Reggie Wayne with 14:53 remaining in the game making it 18-14 Colts. And as usual, the Colts defense, namely their secondary, shut down Smith and the 49ers passing attack the rest of the way, sealing the victory.

Manning, despite going 31-of-48 for 347 yards with no TD’s or interceptions, was not exactly efficient; meanwhile, Smith went 19-of-32 for 198 yards with a TD and an INT. Addai accounted for the vast majority of the Colts’ rushing yardage as he gained 62 yards on 20 carries while Gore rushed for 91 yards and a score.

Wayne had a career day for the Colts as he caught 12 passes for 147 yards and a TD while Dallas Clark caught 8 passes for 99 yards; Austin Collie chipped in with 6 catches for 66 yards while Pierre Garcon caught 4 for 53 yards. Rookie Michael Crabtree caught 6 balls for 81 yards to lead all 49ers receivers while Isaac Bruce caught 4 passes for 51 yards.

Indianapolis (7-0) hopes to keep their undefeated streak alive when they host the Houston Texans while San Francisco (3-4) returns home to host the Tennessee Titans – also next Sunday.

Neither Colts RB Donald Brown nor wide receiver Reggie Wayne practiced. Team president Bill Polian told NFL Network that while Brown is unlikely to play this week, Wayne probably would miss only a day or two of practice ahead of the San Francisco 49ers’ visit to Lucas Oil Stadium on Sunday. Like Brown, Wayne (strained groin) was hurt Sunday at St. Louis.

It seems like these days that as certain as there is a sunrise and a sunset, Indianapolis Colts quarterback Peyton Manning will usually provide a good effort – week in, week out. During Sunday’s game agaisnt the St. Louis Rams, it would prove to be no different as Manning threw 3 touchdown passes, allowing Indianapolis to remain undefeated in routing St. Louis 42-6 at the Edward Jones Dome.

The Colts, as they typically do, got an early 7-0 lead in the first quarter as Manning conected with wide receiver Reggie Wayne on a 6-yard TD pass with 8:50 left in the opening period; the Rams would get on the scoreboard nesrly 3 and one-half minutes later as kicker Josh Brown converted on a 30-yard field goal. Indianapolis would score at the 3:31 mark of the quarter on a 27-yard Manning-to-tight end Dallas Clark TD pass, increasing their lead to 14-3 going into the second quarter.

The second period was much quieter, although the Colts would score yet again on a 6-yard TD run by running back Joseph Addai, further extending their lead to 21-3 which they would take to their locker room at halftime.

The Panthers would begin the scoring at the beginning of the third quarter as Brown booted a 45-yard FG with 5:07 left in the quarter, reducing their deficit to 15, but then the route was on for Indianapolis. The Colts’ defesne would get involved in the scoring as cornerback Jacob Lacey would take an interception by Rams QB Marc Bulger 35 yards for a score, padding the Colts advantage to 28-6.

The fourth quarter was all Colts as they would score twice in the period – once on a TD pass from Manning to Austin Collie and a 31-yard TD run by reserve RB Chad Simpson.

Manning, predictably, had another good game as he went 23-of-34 for 235 yards and 3 TD’s while Bulger went 14-of-26 for 140 yards and 2 INT’s. Both teams did well in the rushing department; the Colts, led by Joseph Addai’s 64 yards and a score along with Donald Brown’s 58 yards on only 2 rushes, rushed for 156 yards while the Rams were led by Steven Jackson who ran for 134 yards on 23 carries.

Wayne led all Colts receivers with 7 receptions for 83 yards and a score while Clark caught 3 for 44 and a TD. WR Donnie Avery led the Rams receivers with 2 receptions for 58 yards. Indianapolis (6-0) look to extend their winning streak into next week as they welcome the San Francisco 49ers to Lucas Oil Stadium while St. Louis (0-7) look for their first win of the season when they travel to Detroit to take on the Lions – also next Sunday.

St Louis: WR Brandon Gibson, DL James Hall, OG John Greco, CB Justin King, QB Keith Null, OT Phillip Trautwein, OG Roger Allen, WR Ruvell Martin.